LTB4 Receptor Antagonists Exacerbate T Lymphocyte-Mediated Delayed Hypersensitivity in Guinea Pigs

1997 ◽  
pp. 247-251 ◽  
Author(s):  
Patrick Y-K Wong ◽  
King-Teh Lin ◽  
Henry P. Godfrey
Keyword(s):  
T Lymphocyte ◽  
Guinea Pigs ◽  
Delayed Hypersensitivity ◽  
Receptor Antagonists ◽  
Ltb4 Receptor

scholarly journals DELAYED HYPERSENSITIVITY

1957 ◽  
Vol 105 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Jonathan W. Uhr ◽  
A. M. Pappenheimer ◽  
M. Yoneda
Keyword(s):  
Guinea Pigs ◽  
Diphtheria Toxin ◽  
Intradermal Injection ◽  
Delayed Hypersensitivity ◽  
Toxigenic Strain ◽  
Skin Reactions ◽  
Minute Amount ◽  
Initial Infection ◽  
Toxigenic Strains

Guinea pigs infected by intradermal injection of living toxigenic diphtheria bacilli and protected by horse antitoxic globulin, given either before or after infection, develop delayed hypersensitivity of the tuberculin type to diphtherial proteins. The highest degree of hypersensitivity is specifically directed against diphtheria toxin (or toxoid) itself, although smaller delayed skin reactions may be evoked in sensitized animals by other diphtherial proteins common to both toxigenic and non-toxigenic strains. Animals sensitized to diphtheria toxin by infection with a toxigenic strain in this way react positively to the Schick test and their serum usually contains no detectable antitoxin 2 to 3 weeks after the initial infection. Animals infected with living non-toxigenic diphtheria bacilli become sensitized to proteins common to both toxigenic and non-toxigenic strains but do not show sensitivity to toxin. The observations suggest that a minute amount of toxoid, or of toxin comparable to that which might be liberated during infection, might induce the hypersensitive state if injected in the form of a complex with excess antitoxin. This prediction is verified by the results reported in the following paper (23).

Effects of histamine H1- and H2-receptor antagonists on cardiovascular function during systemic anaphylaxis in guinea pigs

1991 ◽  
Vol 32 (3-4) ◽  
pp. 245-252 ◽  
Author(s):  
S. B. Felix ◽  
G. Baumann ◽  
M. Niemczyk ◽  
T. Hashemi ◽  
G. Ochsenfeld ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Cardiovascular Function ◽  
Receptor Antagonists ◽  
H2 Receptor Antagonists ◽  
H2 Receptor ◽  
Systemic Anaphylaxis

The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930

1993 ◽  
Vol 39 (S1) ◽  
pp. C11-C13 ◽  
Author(s):  
T. D. Penning ◽  
S. W. Djuric ◽  
S. H. Docter ◽  
S. S. Yu ◽  
D. Spangler ◽  
...  
Keyword(s):  
Second Generation ◽  
Leukotriene B4 ◽  
Receptor Antagonists ◽  
Design And Synthesis ◽  
Ltb4 Receptor

scholarly journals REGULATION OF DELAYED HYPERSENSITIVITY

1973 ◽  
Vol 137 (1) ◽  
pp. 32-41 ◽  
Author(s):  
J. M. Dwyer ◽  
F. S. Kantor
Keyword(s):  
Cellular Immunity ◽  
Guinea Pigs ◽  
Delayed Hypersensitivity ◽  
Control Group ◽  
Inflammatory Reactions ◽  
Data Support ◽  
Feedback Inhibitor ◽  
Hypersensitivity Skin ◽  
Normal Macrophage

Two potential mechanisms for terminating delayed hypersensitivity (DH) reactions have been examined in desensitized guinea pigs. Lack of macrophage responsiveness to lymphokines was sought as an explanation for the reduced ability of these animals to express delayed hypersensitivity. Skin-reactive factor was injected into the skin of desensitized guinea pigs and a control group of similarly immunized animals. The resulting inflammatory reactions were similar in size and intensity in both groups indicating normal macrophage responsiveness in the desensitized state. Passive cellular transfer of DH responses to desensitized animals was markedly less successful than transfer to normal animals. However, cells from desensitized guinea pigs did transfer DH responsiveness to normal animals. These data support the concept of a humoral suppressant of cellular immunity, perhaps acting as a feedback inhibitor, produced when guinea pigs are desensitized.

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