Vascular Biology and Pharmacology of Adenosine Receptors

The year 2018 marked the 110th anniversary of Goldmann’s discovery that vascularization is an active process in tissues1 and the 50th anniversary of the concomitant reports from Greenblatt and Shubik2 and Ehrmann and Knoth3 that soluble morphogenic factors are required for cancer angiogenesis. Many other radically transformative paradigms have been introduced in the last decades. To name a few, the molecular search for the identity of master regulators of vascular tone led to the discovery of the Endothelium-Derived Relaxing Factor (EDRF; i.e., NO4), while clinically inspired investigations led to the recognition of the pathophysiological relevance of neoangiogenesis in cancer and tissue healing. This brought about the proposal of blocking angiogenesis to halt tumor growth and stimulating angiogenesis to treat myocardial ischemia and heart failure5-7.

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280-LB: Role of A1 and A3 Adenosine Receptors in Whole Body Glucose Metabolism

Diabetes ◽

10.2337/db19-280-lb ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 280-LB ◽

Cited By ~ 1

Author(s):

SHANU JAIN ◽

DILIP K. TOSH ◽

MARC REITMAN ◽

KENNETH A. JACOBSON

Keyword(s):

Glucose Metabolism ◽

Adenosine Receptors ◽

Whole Body

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Faculty Opinions recommendation of Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016005.199375 ◽

2003 ◽

Author(s):

Luciano Adorini

Keyword(s):

Dendritic Cells ◽

Adenosine Receptors ◽

Cytokine Production ◽

Plasmacytoid Dendritic Cells

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Caffeine, Adenosine Receptors and Estrogen in Toxin Models of Parkinson's Disease

10.21236/ada462198 ◽

2006 ◽

Cited By ~ 1

Author(s):

Michael A. Schwarzshild

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Adenosine Receptors

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Caffeine, Adenosine Receptors and Estrogen in Toxin Models of Parkinson's Disease

10.21236/ada625341 ◽

2009 ◽

Author(s):

Michael A. Schwarzschild

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Adenosine Receptors

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PET Imaging of Adenosine Receptors in Diseases

Current Topics in Medicinal Chemistry ◽

10.2174/1568026619666190708163407 ◽

2019 ◽

Vol 19 (16) ◽

pp. 1445-1463 ◽

Cited By ~ 3

Author(s):

Jindian Li ◽

Xingfang Hong ◽

Guoquan Li ◽

Peter S. Conti ◽

Xianzhong Zhang ◽

...

Keyword(s):

Pet Imaging ◽

Adenosine Receptors ◽

Neurological Diseases ◽

G Protein Coupled Receptors ◽

Extracellular Adenosine ◽

Positron Emission ◽

Imaging Probes ◽

Pet Probes ◽

Cancer And Inflammation ◽

G Protein Coupled

Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer’s disease, and Parkinson’s disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of Positron Emission Tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.

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