Phospholipase A2 Activation: An Early Manifestation of Oxidative Stress

1997 ◽  
pp. 77-107 ◽  
Author(s):  
Alex Sevanian ◽  
Julia Rashba-Step
Keyword(s):  
Oxidative Stress ◽  
Phospholipase A2 ◽  
Early Manifestation

scholarly journals Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0143518 ◽  
Author(s):  
Daishi Yui ◽  
Yoichiro Nishida ◽  
Tomoko Nishina ◽  
Kaoru Mogushi ◽  
Mio Tajiri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phospholipase A2 ◽  
Insulin Degrading Enzyme ◽  
Degrading Enzyme ◽  
Group 3

scholarly journals Eicosanoid turnover in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Angelo A. Izzo ◽  
Jane A. Mitchell
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Cytochrome P450 ◽  
Free Radicals ◽  
Phospholipase A2 ◽  
Oxidative Metabolism ◽  
Molecular Targets ◽  
Structural Analogues ◽  
Biomarkers Of Oxidative Stress

Eicosanoids are 20-carbon fatty acids, where the usual focus is the polyunsaturated analogue arachidonic acid and its metabolites. Arachidonic acid is thought primarily to derive from phospholipase A2 action on membrane phosphatidylcholine, and may be re-cycled to form phospholipid through conjugation with coenzyme A and subsequently glycerol derivatives. Oxidative metabolism of arachidonic acid is conducted through three major enzymatic routes: cyclooxygenases; lipoxygenases and cytochrome P450-like epoxygenases, particularly CYP2J2. Isoprostanes are structural analogues of the prostanoids (hence the nomenclature D-, E-, F-isoprostanes and isothromboxanes), which are produced in the presence of elevated free radicals in a non-enzymatic manner, leading to suggestions for their use as biomarkers of oxidative stress. Molecular targets for their action have yet to be defined.

scholarly journals Genotype × Adiposity Interaction Linkage Analyses Reveal a Locus on Chromosome 1 for Lipoprotein-Associated Phospholipase A2, a Marker of Inflammation and Oxidative Stress

2007 ◽  
Vol 80 (1) ◽  
pp. 168-177 ◽  
Author(s):  
Vincent P. Diego ◽  
David L. Rainwater ◽  
Xing-Li Wang ◽  
Shelley A. Cole ◽  
Joanne E. Curran ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phospholipase A2 ◽  
Chromosome 1 ◽  
Linkage Analyses ◽  
And Oxidative Stress

Everolimus therapy is associated with reduced lipoprotein-associated phospholipase A2 (Lp-Pla2) activity and oxidative stress in heart transplant recipients

2013 ◽  
Vol 230 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Katharina Rosing ◽  
Manfred Fobker ◽  
Frank Kannenberg ◽  
Stefan Gunia ◽  
Angelo Maria Dell'Aquila ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Phospholipase A2 ◽  
Heart Transplant ◽  
Transplant Recipients ◽  
Pla2 Activity ◽  
Heart Transplant Recipients ◽  
And Oxidative Stress

scholarly journals Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2

2012 ◽  
Vol 53 (9) ◽  
pp. 1767-1782 ◽  
Author(s):  
Robert S. Rosenson ◽  
Diana M. Stafforini
Keyword(s):  
Oxidative Stress ◽  
Phospholipase A2
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