Effects of Hormones Other than Parathyroid Hormones on Renal Handling of Phosphate

1980 ◽  
pp. 137-195 ◽  
Author(s):  
Eberhard Ritz ◽  
Wilhelm Kreusser ◽  
Jürgen Bommer
Keyword(s):  
Renal Handling ◽  
Parathyroid Hormones

Effect of insulin on systemic and renal handling of albumin in nondiabetic and NIDDM subjects

Diabetes ◽  
1997 ◽  
Vol 46 (5) ◽  
pp. 868-875 ◽  
Author(s):  
C. Catalano ◽  
E. Muscelli ◽  
A. Quinones Galvan ◽  
S. Baldi ◽  
A. Masoni ◽  
...  
Keyword(s):  
Renal Handling

Quantitative Investigation on Renal Handling of Drugs in Rabbits, Dogs, and Humans

1983 ◽  
Vol 72 (4) ◽  
pp. 440-443 ◽  
Author(s):  
Akira Kamiya ◽  
Katsuhiko Okumura ◽  
Ryohei Hori
Keyword(s):  
Quantitative Investigation ◽  
Renal Handling

EFFECT OF OXIDATION ON BIOLOGICAL AND IMMUNOLOGICAL ACTIVITY OF PORCINE PARATHYROID HORMONE

1974 ◽  
Vol 63 (1) ◽  
pp. 117-124 ◽  
Author(s):  
J. L. H. O'RIORDAN ◽  
J. S. WOODHEAD ◽  
G. N. HENDY ◽  
J. A. PARSONS ◽  
C. J. ROBINSON ◽  
...  
Keyword(s):  
Biological Activity ◽  
Parathyroid Hormone ◽  
Cysteine Oxidation ◽  
Subsequent Reduction ◽  
Immunological Activity ◽  
Parathyroid Hormones ◽  
Methionine Residue

SUMMARY The presence of a single methionine in porcine parathyroid hormone, at position 8, permitted assessment of the role of this residue separate from the second methionine residue found at position 18 of bovine and human parathyroid hormones. Oxidation of the solitary methionine of porcine parathyroid hormone to the sulphoxide destroyed biological activity, but this was restored by subsequent reduction with cysteine. Oxidation of the hormone did not, however, affect its immunological activity; therefore, oxidation of the hormone may bring about dissociation of biological and immunological activity.

scholarly journals Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1959
Author(s):  
Flora O. Vanoni ◽  
Gregorio P. Milani ◽  
Carlo Agostoni ◽  
Giorgio Treglia ◽  
Pietro B. Faré ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Meta Analysis ◽  
Final Analysis ◽  
Magnesium Content ◽  
Chronic Alcohol ◽  
Renal Handling ◽  
Intracellular Magnesium ◽  
Magnesium Depletion ◽  
Statistical Heterogeneity

Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

Renal filtration and excretion of aluminium in the rat: dose-response relationships and effects of aluminium speciation

1995 ◽  
Vol 14 (6) ◽  
pp. 494-499 ◽  
Author(s):  
CJ Lote ◽  
JA Wood ◽  
A. Thewles ◽  
M. Freeman
Keyword(s):  
Filtration Rate ◽  
Rat Plasma ◽  
Tubular Reabsorption ◽  
The Body ◽  
Aluminium Sulphate ◽  
Renal Handling ◽  
Aluminium Speciation ◽  
Aluminium Citrate ◽  
Aluminium Species ◽  
Filtered Load

The known toxicity of aluminium, and the toxicity of agents (such as desferrioxamine) used to remove alumini um from the body, has prompted us to investigate whether there may be ways of enhancing aluminium excretion by exploiting the normal renal handling of aluminium. Aluminium (as sulphate or citrate) was administered intravenously to conscious rats at doses ranging from 25 μg (0.93 μmol) to 800 μg (29.6 μmol) aluminium, and alu minium excretion was monitored over the following 2 h. Measurements of the filterability of aluminium from the rat plasma, and the glomerular filtration rate (inulin clearance), enabled us to calculate the filtered load of alu minium, and hence determine aluminium reabsorption. At all doses of administered aluminium, that adminis tered as sulphate was excreted less effectively than that administered as citrate. This difference was attributable to the much greater filterability of aluminium administered as citrate. However, for any given filtered load, the excre tion of aluminium administered as citrate was not signifi cantly different (in either fractional or absolute terms) from the excretion of aluminium administered as sulphate. It seems likely that, following aluminium sulphate administration, the filtered aluminium may be an alumini um citrate form which is then reabsorbed in the same way as aluminium administered as citrate. It is thus apparent that aluminium removal from the body could be further enhanced if it were possible to pre vent the tubular reabsorption of the aluminium species which is so effectively filtered following aluminium citrate administration.

Transporter‐mediated renal handling of nafamostat mesilate

2004 ◽  
Vol 93 (2) ◽  
pp. 262-272 ◽  
Author(s):  
Qing Li ◽  
Yoshimichi Sai ◽  
Yukio Kato ◽  
Hiromi Muraoka ◽  
Ikumi Tamai ◽  
...  
Keyword(s):  
Nafamostat Mesilate ◽  
Renal Handling
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