scholarly journals Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1959
Author(s):  
Flora O. Vanoni ◽  
Gregorio P. Milani ◽  
Carlo Agostoni ◽  
Giorgio Treglia ◽  
Pietro B. Faré ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Meta Analysis ◽  
Final Analysis ◽  
Magnesium Content ◽  
Chronic Alcohol ◽  
Renal Handling ◽  
Intracellular Magnesium ◽  
Magnesium Depletion ◽  
Statistical Heterogeneity

Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

scholarly journals Dyslipidaemia and mortality in COVID-19 patients - a meta-analysis

QJM ◽  
2021 ◽  
Author(s):  
Marco Zuin ◽  
Gianluca Rigatelli ◽  
Claudio Bilato ◽  
Carlo Cervellati ◽  
Giovanni Zuliani ◽  
...  
Keyword(s):  
Random Effects ◽  
Mortality Risk ◽  
Meta Analysis ◽  
Random Effect ◽  
Final Analysis ◽  
Short Term ◽  
Random Effects Models ◽  
Pooled Prevalence ◽  
Statistical Heterogeneity ◽  
Trim And Fill

Abstract Objective The prevalence and prognostic implications of pre-existing dyslipidaemia in patients infected by the SARS-CoV-2 remain unclear. To perform a systematic review and meta-analysis of prevalence and mortality risk in COVID-19 patients with pre-existing dyslipidaemia. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE and Scopus to locate all the articles published up to January 31, 2021, reporting data on dyslipidaemia among COVID-19 survivors and non-survivors. The pooled prevalence of dyslipidaemia was calculated using a random effects model and presenting the related 95% confidence interval (CI), while the mortality risk was estimated using the Mantel-Haenszel random effects models with odds ratio (OR) and related 95% CI. Statistical heterogeneity was measured using the Higgins I2 statistic. Results Eighteen studies, enrolling 74.132 COVID-19 patients [mean age 70.6 years], met the inclusion criteria and were included in the final analysis. The pooled prevalence of dyslipidaemia was 17.5% of cases (95% CI: 12.3-24.3%, p < 0.0001), with high heterogeneity (I2=98.7%). Pre-existing dyslipidaemia was significantly associated with higher risk of short-term death (OR: 1.69, 95% CI: 1.19-2.41, p = 0.003), with high heterogeneity (I2=88.7%). Due to publication bias, according to the Trim-and-Fill method, the corrected random-effect ORs resulted 1.61, 95% CI 1.13-2.28, p < 0.0001 (one studies trimmed). Conclusions Dyslipidaemia represents a major comorbidity in about 18% of COVID-19 patients but it is associated with a 60% increase of short-term mortality risk.

scholarly journals A meta‐analysis of the efficacy of gabapentin for treating alcohol use disorder

Addiction ◽  
2019 ◽  
Vol 114 (9) ◽  
pp. 1547-1555 ◽  
Author(s):  
Henry R. Kranzler ◽  
Richard Feinn ◽  
Paige Morris ◽  
Emily E. Hartwell
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Meta Analysis

scholarly journals Different aspects of impulsivity in chronic alcohol use disorder with and without comorbid problem gambling

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0227645 ◽  
Author(s):  
Ildikó Kovács ◽  
Ildikó Demeter ◽  
Zoltán Janka ◽  
Zsolt Demetrovics ◽  
Aniko Maraz ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Problem Gambling ◽  
Alcohol Use Disorder ◽  
Chronic Alcohol

scholarly journals Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians

2019 ◽  
Vol 54 (3) ◽  
pp. 216-224
Author(s):  
Michelle J Zaso ◽  
Patricia A Goodhines ◽  
Tamara L Wall ◽  
Aesoon Park
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Meta Analysis ◽  
Alcohol Metabolism ◽  
East Asians

Social cognition in alcohol use disorder: a meta-analysis

Addiction ◽  
2016 ◽  
Vol 112 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Emre Bora ◽  
Nabi Zorlu
Keyword(s):  
Social Cognition ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Meta Analysis

scholarly journals Genome-wide Meta-analysis of Alcohol Use Disorder in East Asians

2021 ◽  
Author(s):  
Hang Zhou ◽  
Rasmon Kalayasiri ◽  
Yan Sun ◽  
Yaira Z. Nuñez ◽  
Hong-Wen Deng ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Association Studies ◽  
Meta Analysis ◽  
East Asian ◽  
Han Chinese ◽  
Polygenic Risk Score ◽  
Genome Wide Association Studies ◽  
East Asians ◽  
Genome Wide

AbstractBACKGROUNDAlcohol use disorder (AUD) is a leading cause of death and disability worldwide. Genome-wide association studies (GWAS) have identified ∼30 AUD risk genes in European populations, but many fewer in East Asians.METHODSWe conducted GWAS and genome-wide meta-analysis of AUD in 13,551 subjects with East Asian ancestry, using published summary data and newly genotyped data from four cohorts: 1) electronic health record (EHR)-diagnosed AUD in the Million Veteran Program (MVP)sample; 2) DSM-IV diagnosed alcohol dependence (AD) in a Han Chinese-GSA (array) cohort;3) AD in a Han Chinese-Cyto (array) cohort; and 4) two AD datasets in a Thai cohort. The MVP and Thai samples included newly genotyped subjects from ongoing recruitment. In total, 2,254 cases and 11,297 controls were analyzed. An AUD polygenic risk score was analyzed in an independent sample with 4,464 East Asians (Kaiser Permanente data from dbGaP). Phenotypes from survey data and ICD-9-CM diagnoses were tested for association with the AUD PRS.RESULTSTwo risk loci were detected: the well-known functional variant rs1229984 in ADH1B and rs3782886 in BRAP (near the ALDH2 gene locus) are the lead variants. AUD PRS was significantly associated with days per week of alcohol consumption (beta = 0.43, se = 0.067, p = 2.47×10−10) and nominally associated with pack years of smoking (beta = 0.09, se = 0.05, p = 4.52×10−2) and ever vs. never smoking (beta = 0.06, se = 0.02, p = 1.14×10−2).CONCLUSIONSThis is the largest GWAS of AUD in East Asians to date. Building on previous findings, we were able to analyze pleiotropy, but did not identify any new risk regions, underscoring the importance of recruiting additional East Asian subjects for alcohol GWAS.

scholarly journals A Systematic Review and Meta-analysis of Alcohol Use Disorders and Its determinants in People Living with HIV in Africa: A Continent based Review and Meta-analysis study.

2020 ◽  
Author(s):  
Mogesie Necho ◽  
Asmare Belete ◽  
Yibeltal Getachew
Keyword(s):  
Alcohol Use ◽  
Cigarette Smoking ◽  
Sample Size ◽  
Associated Factors ◽  
Alcohol Use Disorder ◽  
Meta Analysis ◽  
Routine Practice ◽  
People Living With Hiv ◽  
Living With Hiv ◽  
Hiv Aids

Abstract Background Alcohol use disorder among people living with HIV/AIDS contributes to decreased adherence and effectiveness of antiretroviral medication, decreased help-seeking to HIV/AIDS care and treatment, increased load of the virus in the blood, and development of drug-resistant HIV strains. This study therefore aimed and assessed the pooled evidence on prevalence and associated factors of alcohol use disorder in retroviral infected patients in Africa. Methods We implemented our electronic data base search on PubMed, Scopus, EMBASE, and Psych-INFO libraries. In addition, WHO websites and Google scholar were also investigated for grey literatures. Moreover, we further investigated the reference lists of published articles. Stata-11meta-prop package with 95% confidence interval was used. Subgroup and sensitivity analysis were also performed. Cochran's Q- and the I2 test were used to check heterogeneity. Publication bias was evaluated with Egger's test and funnel plots. Results In this meta-analysis, we included 22 studies with a total of 16774 patients and the pooled prevalence of alcohol use disorder was 22.03%( 95% CI: 17.18, 28.67). The average prevalence of AUD in South Africa (28.77%) was higher than in Uganda (16.61%) and Nigeria (22.8%). Besides, the average prevalence of AUD in studies published before 2011, 2011–2015, and after 2015 was found to be 13.47%, 24.93% and 22.88% respectively. Moreover, the pooled magnitude of AUD among studies which utilized a sample size > 450 was 16.71% whereas it was 26.46% among studies that utilized sample size < 450. Furthermore, the pooled estimated prevalence of hazardous, harmful and dependent drinking was 10.87%, 8.1%, and 3.12% respectively. Being male was an associated factor for alcohol use disorder (AOR = 5.5%; 95% CI: 1.10, 9.98). Moreover, the average odds ratio of cigarette smoking and chat chewing were found to be 3.95% (95% CI: 3.00, 4.89) and 3.34% (95% CI: 1.71, 4.96) respectively. Conclusion The average estimated prevalence of AUD in HIV/AIDs patients was high and factors such as being Male, cigarette smoking and chat chewing were associated with it. Early detection and appropriate management of AUD and the mentioned associated factors have to be a routine practice.

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