Human-Human Hybridoma Monoclonal Antibodies in Diagnosis and Treatment of Neoplastic Disease

1983 ◽  
pp. 57-66
Author(s):  
Henry S. Kaplan ◽  
Lennart Olsson
Keyword(s):  
Monoclonal Antibodies ◽  
Diagnosis And Treatment ◽  
Neoplastic Disease

Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 1097-1102
Author(s):  
Drashti Desai ◽  
Pravin Shende
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibodies ◽  
Diagnosis And Treatment ◽  
Detection Methods ◽  
Active Immunotherapy ◽  
Immune Checkpoints ◽  
Proliferation Index ◽  
Protein Fusion ◽  
Ki 67 ◽  
Cost Efficient

: Immunotherapy emerges as a treatment strategy for breast cancer marker, diagnosis and treatment. In this review, monoclonal antibodies (mAbs)-based passive and peptide vaccines as active immunotherapy approaches like activation of B-cells and T-cells are studied. Passive immunotherapy is mAbs-based therapy effective against tumor cells, which acts by targeting HER2, IGF 1R, VEGF, BCSC and immune checkpoints. Neuropeptide Y (NPY) and GPCR are the areas of interest to target BC metastases for on-targeting therapeutic action. Neuropeptide S (NPS) or NPS receptor 1, acts as a biomarker for Neuroendocrine tumors (NET), mostly characterized by synaptophysin and chromogranin-A expression or Ki-67 proliferation index. The protein fusion technologies arise as a promising avenue in plant expression systems for increased recombinant Ab accumulation and cost-efficient purification. Recently, mAbs-based immunotherapy effectiveness is appreciated as a novel therapeutic combination of chemotherapy and immunotherapy to reduce the side effects and improve therapeutic responsiveness. Synthetic drug resistance will be overcome by mAbs-based therapy through several clinical trials and detection methods need to be optimized for accuracy and precision. Pharmacokinetic attributes need to be accessed for preferred receptor-agonist activity without ligand accumulation.

Monoclonal antibodies: A potentially powerful tool in the diagnosis and treatment of infectious diseases

1985 ◽  
Vol 4 (3) ◽  
pp. 251-256 ◽  
Author(s):  
G. Spira ◽  
R. R. Pollock ◽  
A. Bargellesi ◽  
M. D. Scharff
Keyword(s):  
Monoclonal Antibodies ◽  
Infectious Diseases ◽  
Diagnosis And Treatment

Abstract 2857: Monoclonal antibodies against novel tumor markers for cancer diagnosis and treatment .

2013 ◽  
Author(s):  
Renata Maria Grifantini ◽  
Piero Pileri ◽  
Matteo Parri ◽  
Alberto Grandi ◽  
Susanna Campagnoli ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Markers ◽  
Cancer Diagnosis ◽  
Diagnosis And Treatment

Side-Effects of Monoclonal Antibody Infusions for the Diagnosis and Treatment of Cancer

1988 ◽  
Vol 3 (3) ◽  
pp. 147-153 ◽  
Author(s):  
E.F.H. van der Linden ◽  
M.J.P.G. van Kroonenburgh ◽  
E.K.J. Pauwels
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Side Effects ◽  
Diagnosis And Treatment ◽  
Target Cells ◽  
Clinical Use ◽  
Skin Reactions ◽  
Discontinuation Of Treatment ◽  
Diagnostic Applications ◽  
Toxic Reactions

This literature review presents an inventory of the nature and incidence of side-effects that arise from the clinical application of monoclonal antibodies (MoAb) for the diagnosis and treatment of cancer. Most side-effects occurred during therapy. Toxic reactions, such as fever, sweating and chills, were more common than immunological skin reactions; they were observed predominantly in association with the elimination of circulating target cells. Dosage and rate of administration of the MoAb appeared to have little influence on the reactions, which disappeared quickly and did not necessitate discontinuation of treatment. Serum sickness, anaphylactic reactions and bronchospasms were not common; the patients reacted quickly to the indicated therapy. Prevention of the side-effects described here, especially during diagnostic applications, was such that they need not form a barrier to the clinical use of MoAb.

Potential value of monoclonal antibodies for the diagnosis and treatment of thrombosis

1990 ◽  
Vol 4 ◽  
pp. 2
Author(s):  
P.J. Gaffney ◽  
L.J. Creighton-Kempsford ◽  
P.M. Tymkewycz
Keyword(s):  
Monoclonal Antibodies ◽  
Diagnosis And Treatment ◽  
Potential Value
Sign in / Sign up

Export Citation Format

Share Document