Genetic and Functional Studies of Guanine Nucleotide-Binding Regulatory Proteins

1984 ◽  
pp. 85-98 ◽  
Author(s):  
Henry R. Bourne ◽  
Cornelis Van Dop ◽  
Gerald F. Casperson
Keyword(s):  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Functional Studies ◽  
Guanine Nucleotide Binding

Hepatocyte beta-adrenergic responsiveness and guanine nucleotide-binding regulatory proteins

1989 ◽  
Vol 256 (2) ◽  
pp. C384-C389 ◽  
Author(s):  
J. A. Garcia-Sainz ◽  
M. E. Huerta-Bahena ◽  
C. C. Malbon
Keyword(s):  
Binding Protein ◽  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding Protein ◽  
Beta Adrenergic ◽  
Adp Ribosylation ◽  
Liver Membranes ◽  
Guanine Nucleotide Binding ◽  
Nucleotide Binding Protein

Hepatocytes isolated from hypothyroid, adrenalectomized, or partially hepatectomized rats display an enhanced beta-adrenergic responsiveness as compared with cells from control animals. The enhanced beta-adrenergic responsiveness is evidenced by both increased ureagenesis and adenosine 3',5'-cyclic monophosphate (cAMP) accumulation in response to isoproterenol. The role of stimulatory guanine nucleotide-binding protein (Gs) and inhibitory guanine nucleotide-binding protein (Gi) in the enhanced responsiveness was studied. It was observed, contrary to what would have been anticipated, that the level of Gs [as reflected by cholera toxin-catalyzed ADP ribosylation, 5'-guanosine gamma-thiotriphosphate (GTP gamma S)-stimulated adenylate cyclase activity, and a functional reconstitution assay] was decreased in liver membranes from adrenalectomized and partially hepatectomized rats as compared with the controls. Furthermore, the level of Gi was increased in these conditions as reflected by pertussis toxin-catalyzed ADP ribosylation. The data suggest that changes in beta-adrenergic receptor levels rather than the levels of guanine nucleotide-binding (G) regulatory proteins predominate in regulation of hepatic beta-adrenergic responses by hypothyroidism, adrenalectomy, or partial hepatectomy.

scholarly journals Interaction of guanine-nucleotide-binding regulatory proteins with chemotactic peptide receptors in differentiated human leukemic HL-60 cells

1991 ◽  
Vol 195 (2) ◽  
pp. 527-533 ◽  
Author(s):  
Masahiro TOHKIN ◽  
Naoki MORISHIMA ◽  
Taroh IIRI ◽  
Katsunobu TAKAHASHI ◽  
Michio UI ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Chemotactic Peptide ◽  
Peptide Receptors ◽  
Guanine Nucleotide Binding

scholarly journals Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells

1992 ◽  
Vol 208 (3) ◽  
pp. 729-737 ◽  
Author(s):  
Romano REGAZZI ◽  
Lucia VALLAR ◽  
Susanne ULLRICH ◽  
Mariella RAVAZZOLA ◽  
Akira KIKUCHI ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Pc12 Cells ◽  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Insulin Secreting Cells ◽  
Guanine Nucleotide Binding

Immunocytochemical and biochemical characterization of guanine nucleotide-binding regulatory proteins in mammalian spermatozoa

1991 ◽  
Vol 146 (2) ◽  
pp. 438-450 ◽  
Author(s):  
Michael Glassner ◽  
Jolynda Jones ◽  
Isaac Kligman ◽  
Marilyn J. Woolkalis ◽  
George L. Gerton ◽  
...  
Keyword(s):  
Biochemical Characterization ◽  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding ◽  
Mammalian Spermatozoa

Effect of metoprolol on activity of β-adrenoceptor coupled to guanine nucleotide binding regulatory proteins in adriamycin-induced cardiotoxicity

1991 ◽  
Vol 86 (2) ◽  
pp. 117-126 ◽  
Author(s):  
L. X. Fu ◽  
C-H. Bergh ◽  
J. Hoebeke ◽  
Q. M. Liang ◽  
K. G. Sjögren ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Regulatory Proteins ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding
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