Multiple Forms of Growth Hormone

1988 ◽  
pp. 43-55
Author(s):  
U. J. Lewis ◽  
R. N. P. Singh ◽  
L. J. Lewis ◽  
N. Abadi
Keyword(s):  
Growth Hormone ◽  
Multiple Forms

Detection of the Multiple Forms of Human Growth Hormone

Acromegaly ◽  
1987 ◽  
pp. 27-34 ◽  
Author(s):  
U. J. Lewis ◽  
R. N. P. Singh ◽  
L. J. Lewis ◽  
N. Abadi
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Multiple Forms

Multiple Forms of Immunoreactive Growth Hormone-Releasing Hormone in Human Plasma, Hypothalamus, and Tumor Tissues*

1989 ◽  
Vol 68 (1) ◽  
pp. 180-185 ◽  
Author(s):  
ATSUSHI SASAKI ◽  
SHUICHI SATO ◽  
SHIGERU YUMITA ◽  
KUNIHIKO HANEW ◽  
YUKIO MIURA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Plasma ◽  
Growth Hormone Releasing Hormone ◽  
Multiple Forms ◽  
Releasing Hormone ◽  
Tumor Tissues

MULTIPLE FORMS OF HUMAN PANCREATIC GROWTH HORMONE RELEASING FACTOR-LIKE IMMUNOREACTIVITY IN TELEOST BRAIN AND PITUITARY

Endocrinology ◽  
1985 ◽  
Vol 116 (4) ◽  
pp. 1663-1665 ◽  
Author(s):  
J.X. PAN ◽  
R.M. LECHAN ◽  
H.D. LIN ◽  
J. SOHN ◽  
S. REICHLIN ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Multiple Forms ◽  
Growth Hormone Releasing Factor ◽  
Pancreatic Growth ◽  
Teleost Brain

Measurement of Multiple Forms of Human Growth Hormone: Cross-Reactivities in Conventional and Two-Chain Radioimmunoassays*

Endocrinology ◽  
1980 ◽  
Vol 106 (1) ◽  
pp. 92-97 ◽  
Author(s):  
M. B. SIGEL ◽  
W. P. VANDERLAAN ◽  
E. F. VANDERLAAN ◽  
U. J. LEWIS
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Multiple Forms

Multiple forms of growth hormone: detection in medium from cultured pituitary adenoma explants

1981 ◽  
Vol 98 (1) ◽  
pp. 8-13 ◽  
Author(s):  
F. Talamantes ◽  
J. Lopez ◽  
U. J. Lewis ◽  
C. B. Wilson
Keyword(s):  
Growth Hormone ◽  
Culture Medium ◽  
Explant Culture ◽  
The Other ◽  
Lower Amount ◽  
Multiple Forms ◽  
Rat Pituitary ◽  
Pituitary Glands ◽  
Defined Culture

Abstract. Three pituitary adenomas obtained from patients with acromegaly were maintained in organ explant culture for a period of 12 days in a defined culture medium. Lyophilized culture medium from each was then examined by electrophoresis to determine which forms of growth hormone were secreted by the explants. All three explants secreted principally the major form of growth hormone. One adenoma however secreted unusually large amounts of two slowly migrating forms which were in low concentration in the GH-containing granules of normal pituitaries. On the other hand the adenoma produced a much lower amount of a 20,000-dalton variant than was seen in normal pituitary glands. The other two adenomas did not secrete the relatively large amounts of the slowly migrating forms although the quantity of the 20,000-dalton form was less than the amount seen in the normal pituitary. There was no evidence of proteolytic alteration of the growth hormone during the culturing process. In companion experiments with rat pituitary glands the growth hormone did not undergo proteolytic degradation in the gland left in situ for 96 h at 5°C.

Multiple Forms of Human Growth Hormone

1986 ◽  
pp. 439-447 ◽  
Author(s):  
Urban J. Lewis ◽  
Luciano G. Frigeri ◽  
Morton B. Sigel ◽  
Gene F. Tutwiler ◽  
Willard P. Vanderlaan
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Multiple Forms

Identifying suboptimalities with factorial model comparison

2018 ◽  
Vol 41 ◽  
Author(s):  
Wei Ji Ma
Keyword(s):  
Experimental Design ◽  
Model Comparison ◽  
Process Models ◽  
Multiple Forms ◽  
Factorial Experimental Design ◽  
Factorial Model ◽  
Multiple Components ◽  
The Many

AbstractGiven the many types of suboptimality in perception, I ask how one should test for multiple forms of suboptimality at the same time – or, more generally, how one should compare process models that can differ in any or all of the multiple components. In analogy to factorial experimental design, I advocate for factorial model comparison.

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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