Mammalian DNA Polymerase α Holoenzyme

1984 ◽  
pp. 321-330 ◽  
Author(s):  
Ulrich Hübscher ◽  
Hans-Peter Ottiger
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α

Intracellular localization and metabolism of DNA polymerase α in human cells visualized with monoclonal antibody

1984 ◽  
Vol 151 (1) ◽  
pp. 123-133 ◽  
Author(s):  
Hiromu Nakamura ◽  
Toshiteru Morita ◽  
Shiego Masaki ◽  
Shonen Yoshida
Keyword(s):  
Monoclonal Antibody ◽  
Dna Polymerase ◽  
Intracellular Localization ◽  
Human Cells ◽  
Dna Polymerase Α

Age-related changes in DNA polymerase α expression

1989 ◽  
Vol 24 (5-6) ◽  
pp. 395-413 ◽  
Author(s):  
D. Busbee ◽  
V. Sylvia ◽  
G. Curtin ◽  
S. Peng ◽  
V. Srivastava ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α ◽  
Age Related ◽  
Age Related Changes

scholarly journals Excision repair of UV-damaged plasmid DNA inXenopusoocytes is mediated by DNA polymerase α (and/or δ)

1990 ◽  
Vol 18 (24) ◽  
pp. 7425-7432 ◽  
Author(s):  
Jitendra K. Saxena ◽  
John B. Hays ◽  
Eric J. Ackerman
Keyword(s):  
Dna Polymerase ◽  
Plasmid Dna ◽  
Excision Repair ◽  
Dna Polymerase Α

scholarly journals Mutational Studies of Human DNA Polymerase α

1995 ◽  
Vol 270 (37) ◽  
pp. 21563-21570 ◽  
Author(s):  
Qun Dong ◽  
Teresa S.-F. Wang
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α ◽  
Human Dna

Immunohistochemical study of p53 expression in endometrial carcinomas: correlation with markers of proliferating cells and clinicopathologic features

1993 ◽  
Vol 3 (6) ◽  
pp. 363-368 ◽  
Author(s):  
T. Hachisuga ◽  
K. Fukuda ◽  
M. Uchiyama ◽  
N. Matsuo ◽  
T. Iwasaka ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Proliferative Activity ◽  
P53 Protein ◽  
Myometrial Invasion ◽  
Proliferating Cells ◽  
Ki 67 ◽  
Normal Endometrium ◽  
P53 Expression ◽  
Dna Polymerase Α ◽  
Endometrial Carcinomas

Using anti-p53 (PAb1801 and PAb240), anti-DNA polymerase α and Ki-67 monoclonal antibodies, the expression of p53 was studied in 11 normal endometria, 14 endometrial hyperplasias and 27 endometrial carcinomas and its relationship to the proliferative activity of the tumors was examined. Normal endometria and simple hyperplasias were completely negative for p53. The PAb1801 indices of complex hyperplasias and complex atypical hyperplasias were 2.5±1.8% and 5.0±3.2%, respectively. The PAb1801 indices of grade 1, grade 2 and grade 3 endometrial carcinomas were 10.2±14.2%, 44.4±29/0% and 45.0±32.5%, respectively. These results indicate a progressively enhanced p53 expression in the sequence from normal endometrium, through hyperplasia to carcinoma. A significant correlation between p53 expression and labeling indices of Ki-67 and DNA polymerase α was observed in endometrial carcinomas. The endo-metrial carcinomas with p53 overexpression developed mainly in post-menopausal patients and were frequently high-grade tumors with deep myometrial invasion. These findings may indicate that overexpression of p53 protein contributes to the proliferative activity of the tumor cells.

scholarly journals DNA polymerase α and models for proofreading

1985 ◽  
Vol 13 (1) ◽  
pp. 261-274 ◽  
Author(s):  
John Abbotts ◽  
Lawrence A. Loeb
Keyword(s):  
Dna Polymerase ◽  
Dna Polymerase Α
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