Recognition of MHC Class II Antigens by the CD4: T Cell Receptor Complex

H-2 Antigens ◽  
1987 ◽  
pp. 441-449
Author(s):  
Charles A. Janeway ◽  
Pilar Portoles ◽  
John P. Tite ◽  
Jose Rojo ◽  
Kaj Saizawa ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Receptor Complex ◽  
Mhc Class Ii Antigens ◽  
Class Ii Antigens

scholarly journals Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 ◽  
Vol 169 (4) ◽  
pp. 1295-1307 ◽  
Author(s):  
D Vercelli ◽  
H H Jabara ◽  
K Arai ◽  
R S Geha
Keyword(s):  
T Cell ◽  
B Cells ◽  
B Cell ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Cell Interaction ◽  
Class Ii ◽  
Ige Synthesis ◽  
Mhc Class Ii Antigens ◽  
Class Ii Antigens

The induction of IgE synthesis by IL-4 requires T cells and monocytes, as well as T cell- and monocyte-derived cytokines. Optimal cytokine combinations, however, fail to induce highly purified B cells to secrete IgE, indicating that additional signals are required. We show herein that the induction of human IgE synthesis by rIL-4 requires cognate interaction between the T cell receptor/CD3 complex on T cells and MHC class II antigens on B cells: mAbs directed against these molecules completely blocked IL-4-dependent IgE induction. mAbs against cell adhesion molecules (CD2, CD4, LFA-1) also inhibited IgE synthesis induced by IL-4, confirming that cell-cell contact is necessary for IgE induction. The requirement for cognate T/B cell interaction was further shown by comparing the IgE-inducing ability of two human IL-4-producing alloreactive T cell clones: F6, which recognizes MHC class II antigens on both B cells and monocytes, and A1, which recognizes an HLA-DP-associated epitope expressed on monocytes, but not on B cells. When incubated with B cells and monocytes from a normal donor bearing the appropriate alloantigen, clone F6, but not clone A1, induced vigorous IgE synthesis, although both clones proliferated and secreted IL-4. Taken together, our results suggest that at least two, possibly synergizing, signals are required for the T cell-dependent induction of IgE synthesis by B cells: one signal is delivered by cognate T/B cell interaction, the other by T cell-derived IL-4.

Vulnerability of allografts to rejection by MHC class II-restricted T-cell receptor transgenic mice1

2003 ◽  
Vol 75 (8) ◽  
pp. 1415-1422 ◽  
Author(s):  
Major K. Lee ◽  
Xiaolun Huang ◽  
Beth P. Jarrett ◽  
Daniel J. Moore ◽  
Niraj M. Desai ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii

scholarly journals MHC class II engagement inhibits CD99-induced apoptosis and up-regulation of T cell receptor and MHC molecules in human thymocytes and T cell line

FEBS Letters ◽  
2003 ◽  
Vol 546 (2-3) ◽  
pp. 379-384 ◽  
Author(s):  
Min Kyung Kim ◽  
Yoon-La Choi ◽  
Min Kyung Kim ◽  
Seok-Hyung Kim ◽  
Eun Young Choi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Line ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Mhc Molecules ◽  
Induced Apoptosis

The role of N-linked oligosaccharides of MHC class II antigens in T cell stimulation

1994 ◽  
Vol 172 (1) ◽  
pp. 95-104 ◽  
Author(s):  
Bishwajit Nag ◽  
H. Garrett Wada ◽  
Subhashini Arimilli ◽  
Katherine Fok ◽  
David Passmore ◽  
...  
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Cell Stimulation ◽  
T Cell Stimulation ◽  
Mhc Class Ii Antigens ◽  
Class Ii Antigens

Structural basis for the recognition of mutant self by a tumor-specific, MHC class II–restricted T cell receptor

2007 ◽  
Vol 8 (4) ◽  
pp. 398-408 ◽  
Author(s):  
Lu Deng ◽  
Ries J Langley ◽  
Patrick H Brown ◽  
Gang Xu ◽  
Leslie Teng ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Structural Basis

Human T-cell receptor TCRAV, TCRBV, and TCRAJ sequences newly found in T-cell clones reactive with allogeneic HLA class II antigens

1993 ◽  
Vol 38 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Fumiya Obata ◽  
Misao Tsunoda ◽  
Takehisa Kaneko ◽  
Koichi Ito ◽  
Ichiro Ito ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Class Ii ◽  
Hla Class Ii ◽  
T Cell Clones ◽  
Human T Cell ◽  
Cell Clones ◽  
Class Ii Antigens

T cell receptor recognition of MHC class II-bound peptide flanking residues results in altered Vβ usage and profound functional dependency

1997 ◽  
Vol 56 ◽  
pp. 6-7
Author(s):  
Richard T. Carson ◽  
Kate M. Vignali ◽  
David L. Woodland ◽  
Dario A.A. Vignali
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mhc Class Ii ◽  
Cell Receptor ◽  
Class Ii ◽  
Functional Dependency ◽  
Receptor Recognition
Sign in / Sign up

Export Citation Format

Share Document