Recent Advances in Understanding the Immunobiology of Gestational Trophoblastic Disease

Background: The most common benign pathological lesion in women of reproductive age is uterine leiomyoma. Gestational trophoblastic disease includes tumors and tumor like lesions originating from trophoblastic tissue. The aim of this study was to ﬁnd the spectrum of molar pregnancy and uterine pathologies focusing on gestational trophoblastic disease as no study has been done in the past few years. Methods: Endometrial and uterine specimens of patients (n=436) between the ages of 15-65 years were collected from a private hospital in Karachi from December 2018 to December 2019. This cross-sectional study was carried out by pathological diagnosis of patients’ samples under light microscopy using hematoxylin and eosin staining. Stratiﬁcation was done about age and nature of specimen to control the effect modiﬁers. The post stratiﬁcation Chi square test was applied and p value <0.05 was considered signiﬁcant. Results: Mean age of the patients was 36.1 years ±7.8. Total 436 uterine biopsies included 260(59.6%) hysterectomies, 56(12.8%) endometrial curetting’s, 117(26.8%) evacuation specimens and 3(0.7%) polypectomies. Common pathologies included 124(28.4%) leiomyomas, 61(14%) proliferative endometrium, 52(11.9%) adenomyosis and 32(7.3%) endometrial polyps. Gestational trophoblastic disease was seen in 9(2.06%). Seven (87.5%) were partial hydatidiform moles, one (12.5%) exaggerated placental site reaction and one choriocarcinoma. Mole was common between 26-30 years with mean age of 27.2 years and prevalence was 6/100 abortions. Conclusion: Leiomyoma was the commonest (28.4%) uterine pathology followed by proliferative endometrium (14.5%). However, endometrial stromal sarcoma and endometriosis were found 0.2% each. High prevalence of mole was seen in this study. Partial mole was most common and choriocarcinoma was least common. Keywords: Hydatidiform Mole; Pathology; Prevalence.

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GESTATIONAL TROPHOBLASTIC DISEASE: INCREASE OF INCIDENCE IN CARLOS VAN BUREN HOSPITAL, VALPARAISO - CHILE: IGCS-0074 Gestational Trophoblastic Neoplasia

International Journal of Gynecological Cancer ◽

10.1136/00009577-201505001-00032 ◽

2015 ◽

Vol 25 (Supp 1) ◽

pp. 42-42

Author(s):

C. Bazan ◽

S. Parry ◽

H. Riesle

Keyword(s):

Gestational Trophoblastic Disease ◽

Gestational Trophoblastic Neoplasia ◽

Trophoblastic Disease

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A retrospective comparison of current and proposed staging and scoring systems for persistent gestational trophoblastic disease

International Journal of Gynecological Cancer ◽

10.1046/j.1525-1438.2000.010004318.x ◽

2000 ◽

Vol 10 (4) ◽

pp. 318-322 ◽

Cited By ~ 34

Author(s):

B.W. Hancock ◽

E.M. Welch ◽

A.M. Gillespie ◽

E.S. Newlands

Keyword(s):

Scoring Systems ◽

Gestational Trophoblastic Disease ◽

Trophoblastic Disease ◽

Retrospective Comparison

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Choriocarcinoma with uterine rupture presenting as acute haemoperitoneum and shock

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20170603 ◽

2017 ◽

Vol 6 (3) ◽

pp. 1141 ◽

Cited By ~ 2

Author(s):

Mamour Gueye ◽

Mame Diarra Ndiaye Gueye ◽

Ousmane Thiam ◽

Youssou Toure ◽

Mor Cisse ◽

...

Keyword(s):

Young Woman ◽

Uterine Rupture ◽

Gestational Trophoblastic Disease ◽

Uterine Perforation ◽

Molar Pregnancy ◽

Rare Neoplasm ◽

Trophoblastic Disease ◽

Intraperitoneal Bleeding ◽

Invasive Mole

Choriocarcinoma is a rare neoplasm and a malignant form of gestational trophoblastic disease. Invasive mole may perforate uterus through the myometrium resulting in uterine perforation and intraperitoneal bleeding. But uterine perforation due to choriocarcinoma is rare. We present a case of a young woman who presented 1 year after uterine evacuation of a molar pregnancy with invasive choriocarcinoma complicated by a uterine rupture and haemoperitoneum.

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