Increased glycolysis as protective adaptation of energy depleted, degenerating human hibernating myocardium

2003 ◽  
pp. 101-107
Author(s):  
Achim M. Vogt ◽  
Albrecht Elsässer ◽  
Holger Nef ◽  
Christoph Bode ◽  
Wolfgang Kübler ◽  
...  
Keyword(s):  
Hibernating Myocardium

Prevalence and Localization of Hibernating Myocardium Among Patients with Left Ventricular Dysfunction

2019 ◽  
Vol 15 (9) ◽  
pp. 884-889
Author(s):  
Emine Acar ◽  
Ayşegül Aksu ◽  
Gökmen Akkaya ◽  
Gamze Çapa Kaya
Keyword(s):  
Scar Tissue ◽  
Left Ventricular ◽  
Hibernating Myocardium ◽  
Circumflex Artery ◽  
Irrigation Area ◽  
Left Circumflex Artery ◽  
Pet Ct ◽  
Perfusion Defects ◽  
The Right ◽  
Fdg Pet Ct

Objective: This study evaluated how much of the myocardium was hibernating in patients with left ventricle dysfunction and/or comorbidities who planned to undergo either surgical or interventional revascularization. Furthermore, this study also identified which irrigation areas of the coronary arteries presented more scar and hibernating tissue. Methods: At rest, Tc-99m MIBI SPECT and cardiac F-18 FDG PET/CT images collected between March 2009 and September 2016 from 65 patients (55 men, 10 women, mean age 64±12) were retrospectively analyzed in order to evaluate myocardial viability. The areas with perfusion defects that were considered metabolic were accepted as hibernating myocardium, whereas areas with perfusion defects that were considered non-metabolic were accepted as scar tissue. Results: Perfusion defects were observed in 26% of myocardium, on average 48% were associated with hibernation whereas other 52% were scar tissue. In the remaining Tc-99m MIBI images, perfusion defects were observed in the following areas in the left anterior descending artery (LAD; 31%), in the right coronary artery (RCA; 23%) and in the Left Circumflex Artery (LCx; 19%) irrigation areas. Hibernation areas were localized within the LAD (46%), LCx (54%), and RCA (64%) irrigation areas. Scar tissue was also localized within the LAD (54%), LCx (46%), and RCA (36%) irrigation areas. Conclusion: Perfusion defects are thought to be the result of half hibernating tissue and half scar tissue. The majority of perfusion defects was observed in the LAD irrigation area, whereas hibernation was most often observed in the RCA irrigation area. The scar tissue development was more common in the LAD irrigation zone.

Searching for Hibernating Myocardium

Circulation ◽  
1996 ◽  
Vol 94 (11) ◽  
pp. 2685-2688 ◽  
Author(s):  
A. Iain McGhie ◽  
Arthur Weyman
Keyword(s):  
Hibernating Myocardium

41. Hibernating myocardium detected by positron emission tomography after acute myocardial infarction

1994 ◽  
Vol 15 (4) ◽  
pp. 235
Author(s):  
J. N. Adams ◽  
S. Walton ◽  
M. Norton ◽  
N. Evans ◽  
R. J. Trent
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Hibernating Myocardium ◽  
Positron Emission

scholarly journals Incidence of hibernating myocardium after acute myocardial infarction treated with thrombolysis.

Heart ◽  
1996 ◽  
Vol 75 (5) ◽  
pp. 442-446 ◽  
Author(s):  
J. N. Adams ◽  
M. Norton ◽  
R. J. Trent ◽  
P. Mikecz ◽  
S. Walton ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hibernating Myocardium

Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart?

2003 ◽  
Vol 285 (1) ◽  
pp. H316-H324 ◽  
Author(s):  
Richard Southworth ◽  
Pamela B. Garlick
Keyword(s):  
Rat Heart ◽  
Recovery Of Function ◽  
Electron Microscopic Examination ◽  
Left Ventricular ◽  
Isolated Rat Heart ◽  
Low Flow ◽  
Hibernating Myocardium ◽  
Heart Model ◽  
Electron Microscopic ◽  
Isolated Rat

The clinical hallmarks of hibernating myocardium include hypocontractility while retaining an inotropic reserve (using dobutamine echocardiography), having normal or increased [18F]fluoro-2-deoxyglucose-6-phosphate (18FDG6P) accumulation associated with decreased coronary flow [flow-metabolism mismatch by positron emission tomography (PET)], and recovering completely postrevascularization. In this study, we investigated an isolated rat heart model of hibernation using experimental equivalents of these clinical techniques. Rat hearts ( n = 5 hearts/group) were perfused with Krebs-Henseleit buffer for 40 min at 100% flow and 3 h at 10% flow and reperfused at 100% flow for 30 min (paced at 300 beats/min throughout). Left ventricular developed pressure fell to 30 ± 8% during 10% flow and recovered to 90 ± 7% after reperfusion. In an additional group, this recovery of function was found to be preserved over 2 h of reperfusion. Electron microscopic examination of hearts fixed at the end of the hibernation period demonstrated a lack of ischemic injury and an accumulation of glycogen granules, a phenomenon observed clinically. In a further group, hearts were challenged with dobutamine during the low-flow period. Hearts demonstrated an inotropic reserve at the expense of increased lactate leakage, with no appreciable creatine kinase release. PET studies used the same basic protocol in both dual- and globally perfused hearts (with 250MBq18FDG in Krebs buffer ± 0.4 mmol/l oleate). PET data showed flow-metabolism “mismatch;” whether regional or global,18FDG6P accumulation in ischemic tissue was the same as (glucose only) or significantly higher than (glucose + oleate) control tissue (0.023 ± 0.002 vs. 0.011 ± 0.002 normalized counts · s-1· g-1· min-1, P < 0.05) despite receiving 10% of the flow. This isolated rat heart model of acute hibernation exhibits many of the same characteristics demonstrated clinically in hibernating myocardium.

scholarly journals Myocardial oxygenation in hibernating myocardium: insights from blood oxygen level dependent imaging pre and post revascularization

2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
Suchi Grover ◽  
Darryl Leong ◽  
Craig Bradbrook ◽  
Angela Walls ◽  
Jawad Mazhar ◽  
...  
Keyword(s):  
Blood Oxygen Level Dependent ◽  
Hibernating Myocardium ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Myocardial Oxygenation

scholarly journals Myocardial Cell Death and Apoptosis in Hibernating Myocardium

1997 ◽  
Vol 30 (5) ◽  
pp. 1407-1412 ◽  
Author(s):  
Chunguang Chen ◽  
Lijie Ma ◽  
Douglas R Linfert ◽  
Tianjie Lai ◽  
John T Fallon ◽  
...  
Keyword(s):  
Cell Death ◽  
Myocardial Cell ◽  
Hibernating Myocardium

Clinical importance of stunned and hibernating myocardium

2001 ◽  
Vol 12 (5) ◽  
pp. 387-392 ◽  
Author(s):  
Howard A. Cooper ◽  
Eugene Braunwald
Keyword(s):  
Clinical Importance ◽  
Hibernating Myocardium
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