Approaches to the Quantification of Tissue Pigments by NIR in Vivo Using a Double Beam Method to Multicomponent Curve Fitting Analysis

1989 ◽  
pp. 83-94
Author(s):  
Shoko Nioka ◽  
Kouich Oka
Keyword(s):  
Curve Fitting ◽  
Double Beam ◽  
Beam Method ◽  
Curve Fitting Analysis

scholarly journals Pharmacological curve fitting to analyze cutaneous adrenergic responses

2011 ◽  
Vol 111 (6) ◽  
pp. 1703-1709 ◽  
Author(s):  
Megan M. Wenner ◽  
Thad E. Wilson ◽  
Scott L. Davis ◽  
Nina S. Stachenfeld
Keyword(s):  
Dose Response ◽  
Curve Fitting ◽  
Repeated Measures ◽  
Nonlinear Modeling ◽  
Response Curves ◽  
Data Set ◽  
Sigmoidal Model ◽  
Dose Response Curves ◽  
Cutaneous Vasoconstriction

Although dose-response curves are commonly used to describe in vivo cutaneous α-adrenergic responses, modeling parameters and analyses methods are not consistent across studies. The goal of the present investigation was to compare three analysis methods for in vivo cutaneous vasoconstriction studies using one reference data set. Eight women (22 ± 1 yr, 24 ± 1 kg/m2) were instrumented with three cutaneous microdialysis probes for progressive norepinephrine (NE) infusions (1 × 10−8, 1 × 10−6, 1 × 10−5, 1 × 10−4, and 1 × 10−3 logM). NE was infused alone, co-infused with NG-monomethyl-l-arginine (l-NMMA, 10 mM) or Ketorolac tromethamine (KETO, 10 mM). For each probe, dose-response curves were generated using three commonly reported analyses methods: 1) nonlinear modeling without data manipulation, 2) nonlinear modeling with data normalization and constraints, and 3) percent change from baseline without modeling. Not all data conformed to sigmoidal dose-response curves using analysis 1, whereas all subjects' curves were modeled using analysis 2. When analyzing only curves that fit the sigmoidal model, NE + KETO induced a leftward shift in ED50 compared with NE alone with analyses 1 and 2 ( F test, P < 0.05) but only tended to shift the response leftward with analysis 3 (repeated-measures ANOVA, P = 0.08). Neither maximal vasoconstrictor capacity (Emax) in analysis 1 nor %change CVC change from baseline in analysis 3 were altered by blocking agents. In conclusion, although the overall detection of curve shifts and interpretation was similar between the two modeling methods of curve fitting, analysis 2 produced more sigmoidal curves.

XAFS Study of Molten ZrCl4 in LiCl-KCl Eutectic

2002 ◽  
Vol 57 (5) ◽  
pp. 277-280 ◽  
Author(s):  
Yoshihiro Okamoto ◽  
Haruhiko Motohashi
Keyword(s):  
Fine Structure ◽  
Coordination Number ◽  
Curve Fitting ◽  
Absorption Edge ◽  
Local Structure ◽  
Molten Mixture ◽  
X Ray ◽  
Absorption Fine ◽  
Curve Fitting Analysis ◽  
X Ray Absorption

The local structure of motlen ZrCl4 in LiCl-KCl eutectic was investigated by using an X-ray absorption fine structure (XAFS) of the Zr K-absorption edge. The nearest Zr4+-Cl- distance and coordination number from the curve fitting analysis were (2.51±0.02) Å and 5.9±0.6, respectively. These suggest that a 6-fold coordination (ZrCl6)2- is predominant in the molten mixture.

An evaluation of an in vivo local sound speed estimation technique by the crossed beam method

1990 ◽  
Vol 16 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Masafumi Kondo ◽  
Kinya Takamizawa ◽  
Makoto Hirama ◽  
Kiyoshi Okazaki ◽  
Kazuhiro Iinuma ◽  
...  
Keyword(s):  
Sound Speed ◽  
Speed Estimation ◽  
Estimation Technique ◽  
Beam Method ◽  
Local Sound

Selection and Fitting of Reference Line for Surface Profiles

1976 ◽  
Vol 190 (1) ◽  
pp. 193-201 ◽  
Author(s):  
M. S. Shunmugam ◽  
V. Radhakrishnan
Keyword(s):  
Random Process ◽  
Curve Fitting ◽  
Process Analysis ◽  
The Other ◽  
Reference Line ◽  
Surface Profiles ◽  
Curve Fitting Analysis

SYNOPSIS In this paper, a method to compute the reference line for the surface profiles by the random process analysis is explained. This reference line is compared with the other practical reference lines, namely the electrical mean line and the envelope. This method is also an interesting and useful tool for the curve fitting analysis.

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