Malignant Fibrous Histiocytoma and Limb Amputation

1988 ◽  
pp. 63-69
Author(s):  
Hugh L. Dwyer
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Limb Amputation

scholarly journals Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia

2019 ◽  
Vol 6 (1) ◽  
pp. 35-41
Author(s):  
Takashi Iizumi ◽  
Shosei Shimizu ◽  
Haruko Numajiri ◽  
Hideyuki Takei ◽  
Noboru Yamada ◽  
...  
Keyword(s):  
Proton Beam ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Late Toxicity ◽  
Proton Beam Therapy ◽  
Target Lesion ◽  
Limb Amputation ◽  
Local Hyperthermia

Abstract Purpose: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. The standard treatment is adequate surgical resection; in addition, radiation therapy plays a major role in perioperative treatment in most cases. Herein, we report the case of a patient with a large MFH who was successfully treated with combined proton beam therapy (PBT) and local hyperthermia (LH). Case Presentation: A 60-year-old man presented with a 6×4-cm mass on his left thigh. Histopathology and immunohistochemistry indicated MFH, and he refused limb amputation. He received treatment with PBT at a dose at 72 GyE in 18 fractions. To cover the entire large target lesion, we used a patch-field protocol. He also concurrently received 7 courses of LH. The combination therapy achieved long-term local control without severe acute or late toxicity during the 7-year follow-up period. Conclusions: This case suggests that the combination of PBT and LH may be an option as a limb-preserving treatment for large inoperable MFH in the extremities.

scholarly journals Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

1998 ◽  
Vol 69 (4) ◽  
Author(s):  
M.J. Booth ◽  
S.S. Bastianello ◽  
M. Jiminez ◽  
A. Van Heerden
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Weight Bearing ◽  
Giant Cells ◽  
Acute Onset ◽  
Limb Amputation ◽  
Femoral Diaphysis ◽  
Neoplastic Cells ◽  
Stifle Joint ◽  
Firm Mass

A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

MR Imaging Findings of Malignant Fibrous Histiocytoma of Bone

1996 ◽  
Vol 34 (2) ◽  
pp. 257
Author(s):  
Jeong Hoon Lee ◽  
Ki Soo Kim ◽  
Byung Hee Lee ◽  
Young Soo Do ◽  
Kie Hwan Kim ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Imaging Findings

Malignant Fibrous Histiocytoma

1976 ◽  
Vol 38 (6) ◽  
pp. 910-919 ◽  
Author(s):  
Makoto HORI ◽  
Kazuki MAEZIMA ◽  
Katsutaro NISHIMOTO ◽  
Kazuya EGAMI ◽  
Gyoogi SATOMI ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma

Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis

Pathology ◽  
1990 ◽  
Vol 22 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Julia A. Bridge ◽  
Warren G. Sanger ◽  
James R. Neff ◽  
Michelle M. Hess
Keyword(s):  
Lung Metastasis ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma

Primary malignant fibrous histiocytoma of the uterus — ultrastructural and immunocytochemical studies of two cases

Pathology ◽  
1985 ◽  
Vol 17 (1) ◽  
pp. 36-40 ◽  
Author(s):  
Sheung-To Chou ◽  
D. Fortune ◽  
N.A. Beischer ◽  
G. McLeish ◽  
L.A. Castles ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Immunocytochemical Studies

Malignant Fibrous Histiocytoma in Childhood

1987 ◽  
Vol 7 (3) ◽  
pp. 303-318 ◽  
Author(s):  
Craig Zuppan ◽  
Gary Mierau ◽  
Harry Wilson
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma

LOCAL RECURRENCES AFTER THE TREATMENT OF SOFT TISSUE MALIGNANT FIBROUS HISTIOCYTOMA (UNCLASSIFIEDPLEOMORPHIC SARCOMA) OF THE LIMBS

2019 ◽  
Vol 72 (8) ◽  
pp. 1523-1526
Author(s):  
Oleksandr O. Lytvynenko ◽  
Volodymyr F. Konovalenko ◽  
Anton Yu. Ryzhov
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Primary Treatment ◽  
Radical Excision ◽  
Local Recurrences ◽  
Results Of Treatment

Introduction: The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods. The aim of the study is an improvement of the results of treatment of patients with soft tissue malignant histiocytoma on the basis of determination of factors, influencing local recurrence development. Materials and methods: The basis of our study was a comprehensive analysis of examination and treatment results of 130 patients with MFH of the soft tissue of limbs, of them in 84 patients (64.6%) the recurrences developed. The group included 45 (53.6%) males and 39 (46.4%) females. The major part of patients – 82.1% (60 patients) were older than 40 years. Results and conclusions: The number of recurrences after the treatment in general surgical facilities is 86.9%, whereas in the patients after the treatment in the specialized oncological facilities this figure is twice lower (40%). The characteristic of the medical facility where the patient receives his/her primary treatment largely affects the development of local recurrences, patients’ quality of life and overall survival rates. The surgical method remains the leading modality in the treatment of MFH of ST. Wide and radical excision of tumors in the specialized oncological facilities allows achieving better survival outcomes of the patients.

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