scholarly journals Malignant fibrous histiocytoma of the deep peri-articular tissue of the stifle in a dog : case report

1998 ◽  
Vol 69 (4) ◽  
Author(s):  
M.J. Booth ◽  
S.S. Bastianello ◽  
M. Jiminez ◽  
A. Van Heerden
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Weight Bearing ◽  
Giant Cells ◽  
Acute Onset ◽  
Limb Amputation ◽  
Femoral Diaphysis ◽  
Neoplastic Cells ◽  
Stifle Joint ◽  
Firm Mass

A Belgian shepherd dog aged 4 years and 9 months was presented with acute onset of non-weight bearing lameness and stifle effusion of the left hind limb, caused by the deep form of a malignant fibrous histiocytoma originating in the deep musculature and fascia surrounding the stifle joint. The tumour progressed rapidly in the tissues along the femoral diaphysis with marked periosteal new bone formation. Cytology of a stifle joint aspirate revealed numerous large polygonal neoplastic cells with considerable anisocytosis and anisokaryosis. These cells were present in clusters, with cytoplasmic projections between the cells, but occasionally also occurred singly. Several cells contained multiple cytoplasmic vacuoles and occasional giant cells were also encountered. Adequate tumour-free margins were not possible with radical limb amputation and the dog was euthanased. Macroscopically the tumour appeared as an extensive pale tan, firm mass with scattered small haemorrhages and foci of yellow discolouration. Histologically the tumour consisted of dense neoplastic expanses or multiple nodules, composed of spindle-shaped fibroblastic cells, polygonal histiocytic cells or cell clusters and scattered giant cells with 2-3 nuclei. The polygonal neoplastic cells were frequently present around and invading lymphatics and blood vessels, causing neoplastic emboli. This is the 1st report of the clinical behaviour, radiography and cytology of the deep form of malignant fibrous histiocytoma in the dog.

Multiple Marker Studies on a Malignant Fibrous Histiocytoma with Primary Cutaneous Localization

1988 ◽  
Vol 74 (5) ◽  
pp. 609-615 ◽  
Author(s):  
Silvia Moretti ◽  
Marco Santucci ◽  
Laura Brogelli ◽  
Alessandro Palermo ◽  
Umberto Maria Reali ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Cell Types ◽  
Mononuclear Phagocyte ◽  
Neoplastic Cells ◽  
Phenotypic Profile ◽  
Cytoplasmic Proteins ◽  
Cutaneous Localization ◽  
Marker Studies ◽  
Alpha 1 Antitrypsin

Continuing controversy exists concerning a possible relation between neoplastic cells of malignant fibrous histiocytoma (MFH) and the mononuclear phagocyte system. The aim of this study was to investigate the membrane and cytoenzymatic phenotype of a primary cutaneous MFH, storiform pleomorphic type, and to compare these data with ultrastructural observations. Cytoplasmic proteins (acid phosphatase, non specific esterase, alpha-1 antitrypsin, and lysozyme) suggestive of a mononuclear phagocyte origin were demonstrated in varying amounts in neoplastic cells infiltrating the dermis. Consistent with these data, two (LeuM3 and OKM5) out of four (OKM1 and LeuM1) monoclonal antibodies directed against mononuclear phagocyte antigens stained most of the neoplastic cells. Class II MCH antigens (DR and DQ) were variably expressed on distinct groups of neoplastic cells, suggesting different activation/differentiation states. The results favor the view that the present case of primary cutaneous MFH was of mononuclear phagocyte origin. However, the observed phenotypic profile was expressed on neoplastic cells irrespective of their ultrastructural morphology (histiocytic or fibroblastic). Together with previous data in the literature, the latter finding corroborates the view that distinction between these two cell types in MFH is likely to reflect divergent growth and differentiation patterns rather than histogenesis.

Benign Fibrous Histiocytoma: Report of Case

2003 ◽  
Vol 4 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Ümit Ertaş ◽  
M. Cemil Büyükkurt ◽  
Yasin Çiçek
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Panoramic Radiograph ◽  
Giant Cells ◽  
Benign Fibrous Histiocytoma ◽  
Multinucleated Giant Cells ◽  
Caucasian Male ◽  
Storiform Pattern ◽  
Radiolucent Lesion

Abstract Benign fibrous histiocytoma is a rare and usually painless oral neoplasm found in adults that may affect either soft tissue or bone typically noted in their fifth decade. This case was found in a 32 year-old Caucasian male who presented with a fairly well circumscribed unilocular radiolucent lesion extending from the mandibular right first incisor to the left first premolar and reaching the inferior mandible on a panoramic radiograph. A bony window was created and the intrabony lesion was curetted. Multiple sections revealed a cellular tumor composed of uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthoma cells, multinucleated giant cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesional stroma. Although malignant fibrous histiocytoma of the bone is relatively well known, benign fibrous histiocytoma of the bone is very rare. Citation Ertas U, Büyükkurt MC. Benign Fibrous Histiocytoma: Report of Case. J Contemp Dent Pract 2003 May;(4)2:074-079.

scholarly journals Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia

2019 ◽  
Vol 6 (1) ◽  
pp. 35-41
Author(s):  
Takashi Iizumi ◽  
Shosei Shimizu ◽  
Haruko Numajiri ◽  
Hideyuki Takei ◽  
Noboru Yamada ◽  
...  
Keyword(s):  
Proton Beam ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Late Toxicity ◽  
Proton Beam Therapy ◽  
Target Lesion ◽  
Limb Amputation ◽  
Local Hyperthermia

Abstract Purpose: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. The standard treatment is adequate surgical resection; in addition, radiation therapy plays a major role in perioperative treatment in most cases. Herein, we report the case of a patient with a large MFH who was successfully treated with combined proton beam therapy (PBT) and local hyperthermia (LH). Case Presentation: A 60-year-old man presented with a 6×4-cm mass on his left thigh. Histopathology and immunohistochemistry indicated MFH, and he refused limb amputation. He received treatment with PBT at a dose at 72 GyE in 18 fractions. To cover the entire large target lesion, we used a patch-field protocol. He also concurrently received 7 courses of LH. The combination therapy achieved long-term local control without severe acute or late toxicity during the 7-year follow-up period. Conclusions: This case suggests that the combination of PBT and LH may be an option as a limb-preserving treatment for large inoperable MFH in the extremities.

scholarly journals Case for diagnosis

2012 ◽  
Vol 87 (4) ◽  
pp. 647-648
Author(s):  
Mariana Hammerschmidt ◽  
Luciana Menezes de Azevedo ◽  
Anelisa Ruaro ◽  
Betina Werner ◽  
Alexandre do Nascimento ◽  
...  
Keyword(s):  
Elderly People ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Skin Tumors ◽  
The Body ◽  
Neoplastic Cells ◽  
Atypical Fibroxanthoma ◽  
Cutaneous Tumor

Atypical fibroxanthoma is a rare cutaneous tumor found mainly in elderly people on sun-exposed areas of the body. Histologically, atypical fibroxanthoma is considered a malignant fibrous histiocytoma with bizarre neoplastic cells, marked pleomorphism, hyperchromatic nuclei and abundant mitoses. It must be differentiated from other skin tumors, usually by immunohistochemistry, since its diagnosis is made by exclusion.

Malignant fibrous histiocytoma of the meninges

1981 ◽  
Vol 55 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Uma P. Kalyanaraman ◽  
John J. Taraska ◽  
Joshua A. Fierer ◽  
Patrick W. Elwood
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Of Origin ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Undifferentiated Cells ◽  
The Central Nervous System ◽  
Meningeal Tumors ◽  
Fibroblastic Cells

✓ A case of malignant fibrous histiocytoma arising from the meninges in a 12-year-old boy is reported. This tumor presented as an extracerebral hemorrhagic mass in the left frontal lobe without obvious invasion of the underlying brain. Histologically, a malignant tumor with the characteristic storiform pattern of malignant fibrous histiocytoma with focal areas of hemorrhage was observed. Ultrastructurally, fibroblastic cells, undifferentiated cells, histiocytic-type cells, multinucleated tumor giant cells, and xanthomatous cells were distinctly seen. The possible cell of origin of these meningeal tumors and their prognosis are discussed. The significance of considering this entity in the differential diagnosis of those tumors of the central nervous system with a spindle-cell or xanthomatous component is discussed, and the value of ultrastructural and immunocytochemical study with glial fibrillary acidic protein in the diagnosis is stressed.

Malignant Fibrous Histiocytoma of the Left Atrium

1996 ◽  
Vol 4 (4) ◽  
pp. 230-232
Author(s):  
Rajendar Krishan Suri ◽  
Ratna S Manjari ◽  
Neerod Kumar Jha ◽  
Vaiphei Kim ◽  
Rajnish Juneja ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Malignant Fibrous Histiocytoma ◽  
Left Atrial ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Atrial Myxoma ◽  
Postoperative Course ◽  
Left Atrial Myxoma ◽  
The Right

A 25-year-old female presented with symptoms resembling those of critical mitral stenosis. Echocardiography revealed a left atrial mass without a stalk, which was suspected to be a left atrial myxoma. An irregular soft friable mass was found at surgery. It measured 10 × 8 cm, with finger-like extensions and occupied almost the entire left atrial cavity, extending into the three tributaries of the right pulmonary vein. Histopathology of the excised tumor including electron microscopy showed a pleomorphic cytology interlaced with bundles, areas of necrosis, and occasional bizarre tumor giant cells. Characteristic histiocytes containing lysosomes identified the tumor as malignant fibrous histiocytoma. A postoperative course of radiotherapy with a dose of 4,000 cGy/20 fractions was applied to the mediastinum. At follow-up 4 months later the patient was asymptomatic. This case is reported because of the extreme rarity of left atrial malignant fibrous histiocytoma.

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