scholarly journals Large Malignant Fibrous Histiocytoma Treated with Hypofractionated Proton Beam Therapy and Local Hyperthermia

2019 ◽  
Vol 6 (1) ◽  
pp. 35-41
Author(s):  
Takashi Iizumi ◽  
Shosei Shimizu ◽  
Haruko Numajiri ◽  
Hideyuki Takei ◽  
Noboru Yamada ◽  
...  
Keyword(s):  
Proton Beam ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Late Toxicity ◽  
Proton Beam Therapy ◽  
Target Lesion ◽  
Limb Amputation ◽  
Local Hyperthermia

Abstract Purpose: Malignant fibrous histiocytoma (MFH) is one of the most common soft tissue sarcomas. The standard treatment is adequate surgical resection; in addition, radiation therapy plays a major role in perioperative treatment in most cases. Herein, we report the case of a patient with a large MFH who was successfully treated with combined proton beam therapy (PBT) and local hyperthermia (LH). Case Presentation: A 60-year-old man presented with a 6×4-cm mass on his left thigh. Histopathology and immunohistochemistry indicated MFH, and he refused limb amputation. He received treatment with PBT at a dose at 72 GyE in 18 fractions. To cover the entire large target lesion, we used a patch-field protocol. He also concurrently received 7 courses of LH. The combination therapy achieved long-term local control without severe acute or late toxicity during the 7-year follow-up period. Conclusions: This case suggests that the combination of PBT and LH may be an option as a limb-preserving treatment for large inoperable MFH in the extremities.

LOCAL RECURRENCES AFTER THE TREATMENT OF SOFT TISSUE MALIGNANT FIBROUS HISTIOCYTOMA (UNCLASSIFIEDPLEOMORPHIC SARCOMA) OF THE LIMBS

2019 ◽  
Vol 72 (8) ◽  
pp. 1523-1526
Author(s):  
Oleksandr O. Lytvynenko ◽  
Volodymyr F. Konovalenko ◽  
Anton Yu. Ryzhov
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Primary Treatment ◽  
Radical Excision ◽  
Local Recurrences ◽  
Results Of Treatment

Introduction: The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods. The aim of the study is an improvement of the results of treatment of patients with soft tissue malignant histiocytoma on the basis of determination of factors, influencing local recurrence development. Materials and methods: The basis of our study was a comprehensive analysis of examination and treatment results of 130 patients with MFH of the soft tissue of limbs, of them in 84 patients (64.6%) the recurrences developed. The group included 45 (53.6%) males and 39 (46.4%) females. The major part of patients – 82.1% (60 patients) were older than 40 years. Results and conclusions: The number of recurrences after the treatment in general surgical facilities is 86.9%, whereas in the patients after the treatment in the specialized oncological facilities this figure is twice lower (40%). The characteristic of the medical facility where the patient receives his/her primary treatment largely affects the development of local recurrences, patients’ quality of life and overall survival rates. The surgical method remains the leading modality in the treatment of MFH of ST. Wide and radical excision of tumors in the specialized oncological facilities allows achieving better survival outcomes of the patients.

Tumor and Dosimetric Predictors of Long-Term Visual Outcomes After Proton Beam Therapy of Uveal Melanoma

2014 ◽  
Vol 90 (1) ◽  
pp. S305 ◽  
Author(s):  
A.L. Polishchuk ◽  
D.H. Char ◽  
V. Weinberg ◽  
I.K. Daftari ◽  
T.B. Cole ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uveal Melanoma ◽  
Proton Beam Therapy ◽  
Visual Outcomes

Long-Term Effects of Proton Beam Therapy for Acromegaly

Acromegaly ◽  
1987 ◽  
pp. 221-228 ◽  
Author(s):  
Bernard Kliman ◽  
Raymond N. Kjellberg ◽  
Billie Swisher ◽  
William Butler
Keyword(s):  
Proton Beam ◽  
Proton Beam Therapy ◽  
Long Term Effects

Atypical Fibroxanthoma Arising in a Scar of Discoid Lupus Erythematosus

2014 ◽  
Vol 18 (5) ◽  
pp. 353-355 ◽  
Author(s):  
Vincenzo De Francesco ◽  
Enzo Errichetti ◽  
Enrico Pegolo ◽  
Giuseppe Stinco
Keyword(s):  
Lupus Erythematosus ◽  
Fibrous Histiocytoma ◽  
Early Stage ◽  
Rare Event ◽  
Soft Tissue Sarcomas ◽  
Squamous Cell Carcinomas ◽  
Discoid Lupus Erythematosus ◽  
Atypical Fibroxanthoma ◽  
Basal Cell Carcinomas

Background: Malignant change in the scars of discoid lupus erythematosus (DLE) is a well-known event. In most cases, tumors are of epithelial origin, particularly squamous cell carcinomas and, less frequently, basal cell carcinomas and keratoacanthomas. The onset of soft tissue sarcomas in a DLE scar is a very rare event, however, because only one case of malignant fibrous histiocytoma has been described in the literature. Objective: We describe the first documented report of atypical fibroxanthoma (AFX) arising in an old scar of DLE. Results: Although we cannot exclude an accidental association between AFX and DLE, our case emphasizes that patients with DLE may develop AFX in the context of an old scar. Conclusion: Our finding further underlines the importance of strict and long-term surveillance of people with DLE to identify and remove eventual tumors at an early stage.

scholarly journals Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

2020 ◽  
Vol 17 (4) ◽  
pp. 1426
Author(s):  
Khrystyna Zhurakivska ◽  
Giuseppe Troiano ◽  
Marco Montella ◽  
Lorenzo Lo Muzio ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Soft Tissues ◽  
Fibrous Histiocytoma ◽  
Case Reports ◽  
Soft Tissue Sarcomas ◽  
Clinical Aspects ◽  
Risk Of Death ◽  
Short Period

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).

Long-term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma

2013 ◽  
Vol 87 (2) ◽  
pp. S457-S458 ◽  
Author(s):  
A.L. Russo ◽  
M. Truong ◽  
P.M. Busse ◽  
J. Adams ◽  
D.G. Deschler ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proton Beam ◽  
Squamous Cell ◽  
Proton Beam Therapy ◽  
Long Term Outcomes

Long-term results of proton beam therapy for carcinoma of the uterine cervix

2003 ◽  
Vol 55 (5) ◽  
pp. 1265-1271 ◽  
Author(s):  
Kenji Kagei ◽  
Koichi Tokuuye ◽  
Toshiyuki Okumura ◽  
Kiyoshi Ohara ◽  
Yoshiyuki Shioyama ◽  
...  
Keyword(s):  
Proton Beam ◽  
Uterine Cervix ◽  
Proton Beam Therapy ◽  
Long Term Results
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