From Plant Extract to a cDNA Encoding a Glucosyltransferase Candidate: Proteomics and Transcriptomics as Tools to Help Elucidate Saponin Biosynthesis in Centella asiatica

2016 ◽  
pp. 43-48 ◽  
Author(s):  
Fernanda de Costa ◽  
Carla J. S. Barber ◽  
Darwin W. Reed ◽  
Patrick S. Covello
Keyword(s):  
Plant Extract ◽  
Centella Asiatica ◽  
Saponin Biosynthesis

scholarly journals Molecular cloning of an ester-forming triterpenoid: UDP-glucose 28- O -glucosyltransferase involved in saponin biosynthesis from the medicinal plant Centella asiatica

Plant Science ◽  
2017 ◽  
Vol 262 ◽  
pp. 9-17 ◽  
Author(s):  
Fernanda de Costa ◽  
Carla J.S. Barber ◽  
Yeon-bok Kim ◽  
Darwin W. Reed ◽  
Haixia Zhang ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Molecular Cloning ◽  
Centella Asiatica ◽  
Saponin Biosynthesis

scholarly journals Effect of ethanolic extract of Centella asiatica on pentylene tetrazol induced seizure in albino mice

2020 ◽  
Vol 9 (10) ◽  
pp. 1583
Author(s):  
Ahmed A. Kannoor ◽  
Ramani P. T.
Keyword(s):  
Plant Extract ◽  
Animal Experiments ◽  
Ethanolic Extract ◽  
Centella Asiatica ◽  
Standard Drug ◽  
Anti Epileptic Drug ◽  
Weight One ◽  
Study Parameter ◽  
Albino Mice ◽  
Phytochemical Studies

Background: Various preparations of the plant Centella asiatica were used in traditional medicine for treating memory disorders, insanity, epilepsy, headache, fever and dysentery. Hence this study was conducted to test the effect of Centella asiatica on classical animal model of epilepsy.Methods: First the ethanolic extract of Centella asiatica was subjected to acute toxicity study. Intraperitoneal injection of pentylene tetrazol in albino mice produces seizure. Plant extract was evaluated for protection from these experimental seizures. Four groups of animals were given the extract orally at 100mg, 200mg, 500mg and 1000mg per kilogram body weight. One group received phenobarbitone as standard drug and another group received distilled water as control. Time of onset of clonus is the study parameter. Statistical analysis of data was done using analysis of variance followed by Dunnet's test.Results: Various doses of plant extract ranging from 100mg to 1000mg/kg exhibited protection from experimentally induced seizures. Compared to control, the plant extract showed statistically significant delay in time of onset of clonus.Conclusions: Centella asiatica is potential source of anti-epileptic drug. Detailed phytochemical studies and animal experiments are recommended.

Mutational breeding of Centella asiatica (L.) urban for medicinal purposes

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
T Kaensaksiri ◽  
P Soontornchainaksaeng ◽  
N Soonthornchareonnon ◽  
S Prathanturarug
Keyword(s):  
Centella Asiatica

The inhibitory effect of the crude extract of Centella asiatica on α-amylase activity

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
N Supkamonseni ◽  
A Thinkratok ◽  
R Srisawat
Keyword(s):  
Crude Extract ◽  
Amylase Activity ◽  
Centella Asiatica ◽  
Inhibitory Effect

Evaluation of Regional and Seasonal Variations of Triterpene and Flavonoid Contents in Centella asiatica by HPLC-DAD

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
A Alqahtani ◽  
W Tongkao-on ◽  
KM Li ◽  
V Razmovski-Naumovski ◽  
B Kimble ◽  
...  
Keyword(s):  
Seasonal Variations ◽  
Centella Asiatica

Centella asiatica Protects Against the Toxic Effects of Intracellular beta-amyloid Accumulation

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
N Gray ◽  
J Morré ◽  
J Kelley ◽  
C Maier ◽  
F Stevens ◽  
...  
Keyword(s):  
Centella Asiatica ◽  
Beta Amyloid ◽  
Toxic Effects ◽  
Amyloid Accumulation

High throughput screening to investigate Brazilian Cerrado biome plant extract bank chemical diversity

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
LS Espindola ◽  
RG Dusi ◽  
KR Gustafson ◽  
J McMahon ◽  
JA Beutler
Keyword(s):  
High Throughput ◽  
Plant Extract ◽  
High Throughput Screening ◽  
Chemical Diversity ◽  
Brazilian Cerrado ◽  
Cerrado Biome

Acute renal failure caused by plant extract

2007 ◽  
Vol 148 (9) ◽  
pp. 421-424 ◽  
Author(s):  
Katalin Vágási ◽  
Péter Degrell ◽  
István Késői ◽  
Tibor Kovács ◽  
István Pintér ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Plant Extract

A szerzők egy 48 órája fennálló anuria miatt vizsgált 30 éves nőbeteg esetét ismertetik, aki tartósan szedett Guarana növényőrleményt tartalmazó készítményt, emellett alkalmanként parenteralis nemszteroid fájdalomcsillapítót kapott. A klinikai kép és a laborvizsgálatok akut máj- és veseelégtelenséget mutattak. Az elvégzett vesebiopszia szövettani képe akut tubularis necrosist igazolt. Átmeneti dialíziskezelést követően kompenzáló polyuria mellett vesefunkciós értékei fokozatosan rendeződtek. A szerzők az esetismertetés kapcsán szeretnék felhívni a figyelmet arra, hogy a gyógyszertárakban és egyéb, gyógyhatású készítményeket, étrendkiegészítőket forgalmazó boltokban kapható szabadforgalmú készítmények némelyikének alkalmazása, illetve a gyógyszerészeti hivatal által törzskönyvezett készítményekkel való együttes alkalmazása súlyos veszélyeket rejthet.

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