Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery

2016 ◽  
pp. 153-175 ◽  
Author(s):  
Helene Baribault
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Discovery ◽  
Mouse Models

scholarly journals Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus

2019 ◽  
Vol 10 ◽  
Author(s):  
Liqing Zang ◽  
Yasuhito Shimada ◽  
Hiroko Nakayama ◽  
Wenbiao Chen ◽  
Ayaka Okamoto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models ◽  
Centromere Protein ◽  
Protein X

scholarly journals Correction: A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives

2019 ◽  
Vol 10 (9) ◽  
pp. 6203-6203 ◽  
Author(s):  
Sónia Rocha ◽  
Adelaide Sousa ◽  
Daniela Ribeiro ◽  
Catarina M. Correia ◽  
Vera L. M. Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Discovery ◽  
Chalcone Derivatives ◽  
Hydrolyzing Enzymes

Correction for ‘A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives’ by Sónia Rocha, et al., Food Funct., 2019, DOI: 10.1039/c9fo01298b.

scholarly journals Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus

2014 ◽  
Vol 171 (24) ◽  
pp. 5636-5649 ◽  
Author(s):  
Danit Mechlovich ◽  
Tamar Amit ◽  
Orit Bar-Am ◽  
Orly Weinreb ◽  
Moussa B H Youdim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models ◽  
Molecular Targets

Use of mouse models in studying type 2 diabetes mellitus

2010 ◽  
Vol 12 ◽  
Author(s):  
Angela W.S. Lee ◽  
Roger D. Cox
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models ◽  
Association Studies ◽  
Large Population ◽  
Genome Wide Association Studies ◽  
Novel Genes ◽  
Common Genetic Variants

The use of mouse models in medical research has greatly contributed to our understanding of the development of type 2 diabetes mellitus and the mechanisms of disease progression in the context of insulin resistance and β-cell dysfunction. Maintenance of glucose homeostasis involves a complex interplay of many genes and their actions in response to exogenous stimuli. In recent years, the availability of large population-based cohorts and the capacity to genotype enormous numbers of common genetic variants have driven various large-scale genome-wide association studies, which has greatly accelerated the identification of novel genes likely to be involved in the development of type 2 diabetes. The increasing demand for verifying novel genes is met by the timely development of new mouse resources established as various collaborative projects involving major transgenic and phenotyping centres and laboratories worldwide. The surge of new data will ultimately enable translational research into potential improvement and refinement of current type 2 diabetes therapy options, and hopefully restore quality of life for patients.

scholarly journals Hair corticosterone measurement in mouse models of type 1 and type 2 diabetes mellitus

2017 ◽  
Vol 178 ◽  
pp. 166-171 ◽  
Author(s):  
Rebecca L. Erickson ◽  
Caroline A. Browne ◽  
Irwin Lucki
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Mouse Models

scholarly journals A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α-glucosidase by chalcone derivatives

2019 ◽  
Vol 10 (9) ◽  
pp. 5510-5520 ◽  
Author(s):  
Sónia Rocha ◽  
Adelaide Sousa ◽  
Daniela Ribeiro ◽  
Catarina M. Correia ◽  
Vera L. M. Silva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Drug Discovery ◽  
Competitive Inhibitor ◽  
Therapeutic Drug ◽  
Chalcone Derivatives ◽  
Hydrolyzing Enzymes

Butein, a competitive inhibitor of α-amylase and α-glucosidase enzymes, is a promising therapeutic drug to modulate diabetes mellitus.

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