Cellular and Molecular Aging

2017 ◽  
pp. 39-52
Author(s):  
Priyamvada Rai ◽  
Bruce R. Troen
Keyword(s):  
Molecular Aging

scholarly journals Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

2011 ◽  
Vol 41 (2) ◽  
pp. 279-290 ◽  
Author(s):  
Christin Glorioso ◽  
Sunghee Oh ◽  
Gaelle Guilloux Douillard ◽  
Etienne Sibille
Keyword(s):  
Gene Polymorphism ◽  
Neurological Disease ◽  
Longevity Gene ◽  
Molecular Aging

scholarly journals Pilot study of DNA methylation, molecular aging markers and measures of health and well-being in aging

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chirag M. Vyas ◽  
Aditi Hazra ◽  
Shun-Chiao Chang ◽  
Weiliang Qiu ◽  
Charles F. Reynolds ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Pilot Study ◽  
Well Being ◽  
Molecular Aging ◽  
Health And Well Being

scholarly journals In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

2020 ◽  
Vol 75 (9) ◽  
pp. e53-e62
Author(s):  
Olga Minaeva ◽  
Srikant Sarangi ◽  
Danielle M Ledoux ◽  
Juliet A Moncaster ◽  
Douglas S Parsons ◽  
...  
Keyword(s):  
Light Scattering ◽  
Human Lens ◽  
Fetal Life ◽  
Healthy Human ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Age Dependent ◽  
Molecular Aging

Abstract The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and maximizing health throughout life. The human lens is an ideal tissue for quantitative assessment of molecular aging in vivo. Long-lived proteins in lens fiber cells are expressed during fetal life, do not undergo turnover, accumulate molecular alterations throughout life, and are optically accessible in vivo. We used quasi-elastic light scattering (QLS) to measure age-dependent signals in lenses of healthy human subjects. Age-dependent QLS signal changes detected in vivo recapitulated time-dependent changes in hydrodynamic radius, protein polydispersity, and supramolecular order of human lens proteins during long-term incubation (~1 year) and in response to sustained oxidation (~2.5 months) in vitro. Our findings demonstrate that QLS analysis of human lens proteins provides a practical technique for noninvasive assessment of molecular aging in vivo.

scholarly journals Anticipated Brain Molecular Aging in Major Depression

2012 ◽  
pp. 1 ◽  
Author(s):  
Gaëlle Douillard-Guilloux ◽  
Jean-Philippe Guilloux ◽  
David A. Lewis ◽  
Etienne Sibille
Keyword(s):  
Major Depression ◽  
Molecular Aging

Molecular Aging and Senescence

Gerontology ◽  
1966 ◽  
Vol 12 (2) ◽  
pp. 109-121 ◽  
Author(s):  
I. Gordon Fels
Keyword(s):  
Molecular Aging

Monitoring Molecular Aging of Lens Proteins using Noninvasive Quasi-Elastic Light Scattering

2015 ◽  
Author(s):  
S. Sarangi ◽  
O. Minaeva ◽  
J. A. Moncaster ◽  
F. Weng ◽  
C. Rook ◽  
...  
Keyword(s):  
Light Scattering ◽  
Elastic Light Scattering ◽  
Lens Proteins ◽  
Molecular Aging

scholarly journals Elastin molecular aging promotes MDA ‐ MB ‐231 breast cancer cell invasiveness

FEBS Open Bio ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 1395-1404 ◽  
Author(s):  
Stéphanie Salesse ◽  
Ludivine Odoul ◽  
Lise Chazée ◽  
Christian Garbar ◽  
Laurent Duca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Molecular Aging ◽  
Cell Invasiveness ◽  
Cancer Cell Invasiveness
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