scholarly journals Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.

2003 ◽  
Vol 24 (5) ◽  
pp. 791-802 ◽  
Author(s):  
P. L. Opresko
2014 ◽  
Vol 1842 (12) ◽  
pp. 2387-2394 ◽  
Author(s):  
Jyotirindra Maity ◽  
Vilhelm A. Bohr ◽  
Aparna Laskar ◽  
Parimal Karmakar

2003 ◽  
Vol 14 (10) ◽  
pp. 4221-4229 ◽  
Author(s):  
Juneth Joaquin Partridge ◽  
Joseph Onofrio Lopreiato ◽  
Martin Latterich ◽  
Fred Eliezer Indig

We report a novel nucleolar interaction between the AAA ATPase p97/VCP and the Werner protein (WRNp), a member of the RecQ helicase family. p97/VCP mediates several important cellular functions in eucaryotic cells, including membrane fusion of the endoplasmic reticulum and Golgi and ubiquitin-dependent protein degradation. Mutations in the WRN gene cause Werner syndrome, a genetic disorder characterized by premature onset of aging symptoms, a higher incidence of cancer, and a high susceptibility to DNA damage caused by topoisomerase inhibitors. We observed that both WRNp and valosin-containing protein (VCP) were present in the nucleoplasm and in nucleolar foci in mammalian cells and that WRNp and p97/VCP physically interacted in the nucleoli. Importantly, the nucleolar WRNp/VCP complex was dissociated by treatment with camptothecin, an inhibitor of topoisomerase I, whereas other WRNp-associated protein complexes, such as WRNp/Ku 80, were not dissociated by this drug. Because WRN syndrome cells are sensitive to topoisomerase inhibitors, these observations suggest that the VCP/WRNp interaction plays an important role in WRN biology. We propose a novel role for VCP in the DNA damage response pathway through modulation of WRNp availability.


2009 ◽  
Vol 44 (1-2) ◽  
pp. 131
Author(s):  
O. Popp ◽  
J. Fahrer ◽  
V.A. Bohr ◽  
A. Bürkle
Keyword(s):  

GeroPsych ◽  
2015 ◽  
Vol 28 (2) ◽  
pp. 47-55 ◽  
Author(s):  
Eva-Marie Kessler ◽  
Catherine E. Bowen

Both psychotherapists and their clients have mental representations of old age and the aging process. In this conceptual review, we draw on available research from gerontology, social and developmental psychology, and communication science to consider how these “images of aging” may affect the psychotherapeutic process with older clients. On the basis of selected empirical findings we hypothesize that such images may affect the pathways to psychotherapy in later life, therapist-client communication, client performance on diagnostic tests as well as how therapists select and apply a therapeutic method. We posit that interventions to help both older clients and therapists to reflect on their own images of aging may increase the likelihood of successful treatment. We conclude by making suggestions for future research.


2004 ◽  
Vol 20 (4) ◽  
pp. 262-274 ◽  
Author(s):  
Manuel de Gracia Blanco ◽  
Josep Garre Olmo ◽  
María Marcó Arbonès ◽  
Pilar Monreal Bosch

Summary: Self-concept is a construct consisting of a group of specific self-perceptions that are hierarchically organized. Age-associated changes of self-concept are related to the individual's perception of the changes occurring throughout the aging process. The authors examined external validity and internal consistency of an instrument that has been developed to assess self-concept in older adults and examined self-concept's characteristics in two different contexts. Results confirm the multidimensionality of the scale and show a satisfactory external validity, indicating good discriminatory capacity. Findings support the hypothesis that older people who live in a nursing home have a poor self-esteem, self-concept, and psychological well-being and have a greater presence of depressive symptoms than people who live in their own home.


2013 ◽  
Author(s):  
Li Qu ◽  
Joel Jia Wei Low ◽  
Chengcheng Jiang ◽  
Qiao Dai ◽  
Ting Zhang ◽  
...  

2017 ◽  
Vol 1 (1) ◽  
pp. 31-47 ◽  
Author(s):  
Ori Tavor

Scientific advances in the field of biomedicine have fundamentally changed the ways in which we think about our bodies. Disease, aging, and even death, are no longer seen as inevitable realities but as obstacles that can be controlled, and in some cases even reversed, by technological means. The current discourse, however, can be enriched by an investigation of the various ways in which the aging process was perceived and explained throughout human history. In this article, I argue that in early China, the experience of aging and the challenges and anxieties it produced played a constitutive role in the shaping of religious culture. Drawing on a variety of medical, philosophical, and liturgical sources, I outline two models of aging: one that presented aging, and especially the loss of virility, as an undesirable but solvable condition that can be reversed with the aid of various rejuvenation techniques, and a more socially conscious model that depicted aging as a process of gradual social ascension, a natural but fundamentally unalterable condition that should be accepted, marked, and even celebrated through ritual. I conclude by demonstrating the legacy and lasting influence of these models on two of the most fundamental tenets of Chinese religion: the pursuit of longevity and the ideal of filial piety.


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