Functional and Morphological Analysis of OFF Bipolar Cells

Morphological analysis of the hyperpolarization-activated cyclic nucleotide-gated cation channel 1 (HCN1) immunoreactive bipolar cells in the rabbit retina

The Journal of Comparative Neurology ◽

10.1002/cne.10957 ◽

2003 ◽

Vol 467 (3) ◽

pp. 389-402 ◽

Cited By ~ 13

Author(s):

In-Beom Kim ◽

Eun-Jin Lee ◽

Tae-Hoon Kang ◽

Jin-Woong Chung ◽

Myung-Hoon Chun

Keyword(s):

Cyclic Nucleotide ◽

Morphological Analysis ◽

Bipolar Cells ◽

Cation Channel ◽

Rabbit Retina

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Decision letter for "LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells"

10.1002/cne.24944/v2/decision1 ◽

2020 ◽

Keyword(s):

Bipolar Cells ◽

Rod Photoreceptors

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Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010012031x ◽

1985 ◽

Vol 43 ◽

pp. 726-729

Author(s):

K.S. Kosik ◽

L.K. Duffy ◽

S. Bakalis ◽

C. Abraham ◽

D.J. Selkoe

Keyword(s):

Monoclonal Antibodies ◽

Alzheimer Disease ◽

Human Brain ◽

Neurofibrillary Tangles ◽

Morphological Analysis ◽

High Specificity ◽

Cytoskeletal Proteins ◽

Neuritic Plaque ◽

Protein Chemistry ◽

Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

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