The damage-independent evolution of ageing by selective destruction

Ageing is currently believed to reflect the accumulation of molecular damage due to energetic costs of maintenance, as proposed in disposable soma theory (DST). Here we have used agent-based modelling to describe an alternative theory by which ageing could undergo positive selection independent of energetic costs. We suggest that the selective advantage of fast-growing mutants might necessitate a mechanism of counterselection we name selective destruction, which removes the faster growing cells from the tissue, preventing the threat of morbidity and mortality they pose. As a result, the survival advantage would shift to the slower cells, allowing them to spread, inducing ageing in the form of a metabolic slowdown. Selective destruction could therefore provide a proximal cause of ageing that is both consistent with the gene expression hallmarks of ageing, and independent of accumulating damage. If true, negligible senescence would acquire a new meaning of increased basal mortality.

Use of Lipocavitation in the Treatment of Localized Adiposity: a Review

With the growing demand for body, contouring, non-invasive devices for reducing localized fat have become increasingly popular and have grown exponentially in the last decade. The Lipocavitation technique has been used recently for this purpose and has been evaluated as a method for the selective destruction of adipose tissue. This work has as main objective, to bring up the practice, the mechanism of action in the body and the effects of the use of lipocavitation in the treatment of localized adiposity. This is an exploratory study of bibliographic review, with consultation in the databases of the VHL (Virtual Health Library), PUBMED and MEDLINE and SciELO. The results showed that the lipocavitation technique used in aesthetics to reduce adipocytes allows the destruction of localized fat, facilitating its elimination and contributing to the reduction of localized measures. With the current technological advances, a variety of techniques can be used, or even combined, allowing innovation to professionals, bringing improvement and well-being to each individual.

Naturally occurring photosensitizers and photodynamic therapy: laser or sun?

Introduction. Our understanding of photodynamic therapy (PDT) is crucial for the applications of this treatment. In this physical phenomenon occurs light absorption by the applied photosensitizer, which results in its excitation to higher electron levels. After activation, a series of complex physicochemical processes take place in the tissues, Aim. The aim of this study was to describe the basic naturally occurring photosensitizers used in PDT techniques. This study clarified applications of photosensitizers. Material and methods. This study was used basic information about PDT reaction and the selective destruction of the tumor by photooxidation: a photosensitizer, a light source and oxygen. The papers reviewed here are based on Medline/Pub. Analysis of the literature. Photodynamic therapy is an innovative form of treatment. This method is not a commonly used therapeutic and therapeutic tool, but a supplement to many already tested and analyzed techniques. Thanks to continuous research, this method has a wider and wider range of applications in medicine. Conclusion. The data indicates increased number of papers regarding applications of PDT in medicine.

Electropulse method of selective destruction of abrasive electrocorundum tool

In laboratory conditions the efficiency of electropulse disintegration of scrap abrasive wheels made of electrocorundum has been investigated. It is shown that at the chosen parameters of the process of selective destruction of abrasive scrap, the separation degree of electrocorundum grains, coarseness of which almost corresponds to the initial fraction, is more than 50%.