Assessment of Influenza Virus Hemagglutinin Stalk-Specific Antibody Responses

Author(s):  
Wen-Chun Liu ◽  
Raffael Nachbagauer ◽  
Florian Krammer ◽  
Randy A. Albrecht
Vaccine ◽  
2020 ◽  
Vol 38 (4) ◽  
pp. 852-858
Author(s):  
Alita Kongchanagul ◽  
Karnyart Samnuan ◽  
Ponthip Wirachwong ◽  
Somchaiya Surichan ◽  
Pilaipan Puthavathana ◽  
...  

1996 ◽  
Vol 3 (5) ◽  
pp. 507-510 ◽  
Author(s):  
W A Keitel ◽  
T R Cate ◽  
R L Atmar ◽  
C S Turner ◽  
D Nino ◽  
...  

Vaccine ◽  
1999 ◽  
Vol 17 (18) ◽  
pp. 2245-2258 ◽  
Author(s):  
D.P Lunn ◽  
G Soboll ◽  
B.R Schram ◽  
J Quass ◽  
M.W McGregor ◽  
...  

2019 ◽  
Vol 116 (27) ◽  
pp. 13474-13479 ◽  
Author(s):  
Davide Angeletti ◽  
Ivan Kosik ◽  
Jefferson J. S. Santos ◽  
William T. Yewdell ◽  
Carolyn M. Boudreau ◽  
...  

A major obstacle to vaccination against antigenically variable viruses is skewing of antibody responses to variable immunodominant epitopes. For influenza virus hemagglutinin (HA), the immunodominance of the variable head impairs responses to the highly conserved stem. Here, we show that head immunodominance depends on the physical attachment of head to stem. Stem immunogenicity is enhanced by immunizing with stem-only constructs or by increasing local HA concentration in the draining lymph node. Surprisingly, coimmunization of full-length HA and stem alters stem-antibody class switching. Our findings delineate strategies for overcoming immunodominance, with important implications for human vaccination.


1974 ◽  
Vol 140 (6) ◽  
pp. 1571-1578 ◽  
Author(s):  
Jean-Louis Virelizier ◽  
Anthony C. Allison ◽  
Geoffrey C. Schild

Mice immunized sequentially with two related influenza virus hemagglutinins (HA) produced a secondary antibody response with two different specificities. Some antibodies were specific for determinants common to both HA's. Paradoxically, some antibodies were directed to determinants existing only in the HA first encountered. Primed spleen cells treated with anti-θ serum and complement were transferred from animals immunized with the first HA to either normal, irradiated, or thymus-deprived recipients. These memory cells were boosted in the recipients with either the homologous or the heterologous cross-reacting HA. B-memory lymphocytes were shown to be directly triggered by both HA's and to be able to secrete, independently of T lymphocytes, antibodies to both kinds of determinants. However, T cells were shown to modulate this secondary response by either enhancing or suppressing antibody secretion by B-memory cells, depending on experimental conditions. These results are discussed in terms of antigen recognition by B cells and of kinetics of development of immunological memory.


2017 ◽  
Vol 198 (7) ◽  
pp. 2785-2795 ◽  
Author(s):  
Arnar Gudjonsson ◽  
Anna Lysén ◽  
Sreekumar Balan ◽  
Vibeke Sundvold-Gjerstad ◽  
Catharina Arnold-Schrauf ◽  
...  

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