Transcriptional Coactivators in Cancer

2000 ◽  
pp. 373-381
Author(s):  
Paul S. Meltzer
Keyword(s):  
Transcriptional Coactivators

scholarly journals Differential Gene Regulation by Selective Association of Transcriptional Coactivators and bZIP DNA-Binding Domains

2006 ◽  
Vol 26 (16) ◽  
pp. 5969-5982 ◽  
Author(s):  
Benoit Miotto ◽  
Kevin Struhl
Keyword(s):  
Dna Binding ◽  
Regulation Of Gene Expression ◽  
Dna Binding Domains ◽  
Binding Domains ◽  
Transcriptional Coactivators ◽  
Differential Gene Regulation ◽  
Arginine Residues ◽  
Contact Dna ◽  
Bzip Proteins ◽  
Basic Region

ABSTRACT bZIP DNA-binding domains are targets for viral and cellular proteins that function as transcriptional coactivators. Here, we show that MBF1 and the related Chameau and HBO1 histone acetylases interact with distinct subgroups of bZIP proteins, whereas pX does not discriminate. Selectivity of Chameau and MBF1 for bZIP proteins is mediated by residues in the basic region that lie on the opposite surface from residues that contact DNA. Chameau functions as a specific coactivator for the AP-1 class of bZIP proteins via two arginine residues. A conserved glutamic acid/glutamine in the linker region underlies MBF1 specificity for a subgroup of bZIP factors. Chameau and MBF1 cannot synergistically coactivate transcription due to competitive interactions with the basic region, but either protein can synergistically coactivate with pX. Analysis of Jun derivatives that selectively interact with these coactivators reveals that MBF1 is crucial for the response to oxidative stress, whereas Chameau is important for the response to chemical and osmotic stress. Thus, the bZIP domain mediates selective interactions with coactivators and hence differential regulation of gene expression.

scholarly journals Conditional Knockout Mice Reveal Distinct Functions for the Global Transcriptional Coactivators CBP and p300 in T-Cell Development

2006 ◽  
Vol 26 (3) ◽  
pp. 789-809 ◽  
Author(s):  
Lawryn H. Kasper ◽  
Tomofusa Fukuyama ◽  
Michelle A. Biesen ◽  
Fayçal Boussouar ◽  
Caili Tong ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cells ◽  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Conditional Knockout ◽  
Specific Cell ◽  
Creb Binding Protein ◽  
Thymocyte Development ◽  
Transcriptional Coactivators

ABSTRACT The global transcriptional coactivators CREB-binding protein (CBP) and the closely related p300 interact with over 312 proteins, making them among the most heavily connected hubs in the known mammalian protein-protein interactome. It is largely uncertain, however, if these interactions are important in specific cell lineages of adult animals, as homozygous null mutations in either CBP or p300 result in early embryonic lethality in mice. Here we describe a Cre/LoxP conditional p300 null allele (p300 flox ) that allows for the temporal and tissue-specific inactivation of p300. We used mice carrying p300 flox and a CBP conditional knockout allele (CBP flox ) in conjunction with an Lck-Cre transgene to delete CBP and p300 starting at the CD4− CD8− double-negative thymocyte stage of T-cell development. Loss of either p300 or CBP led to a decrease in CD4+ CD8+ double-positive thymocytes, but an increase in the percentage of CD8+ single-positive thymocytes seen in CBP mutant mice was not observed in p300 mutants. T cells completely lacking both CBP and p300 did not develop normally and were nonexistent or very rare in the periphery, however. T cells lacking CBP or p300 had reduced tumor necrosis factor alpha gene expression in response to phorbol ester and ionophore, while signal-responsive gene expression in CBP- or p300-deficient macrophages was largely intact. Thus, CBP and p300 each supply a surprising degree of redundant coactivation capacity in T cells and macrophages, although each gene has also unique properties in thymocyte development.

Cooperation of the Transcriptional Coactivators CBP and p300 with Stat6

1999 ◽  
Vol 19 (7) ◽  
pp. 711-722 ◽  
Author(s):  
Christine Mcdonald ◽  
Nancy C. Reich
Keyword(s):  
Transcriptional Coactivators

Abstract 2139: Hippo pathway transcriptional coactivators YAP/TAZ in soft tissue and bone tumors

2019 ◽  
Author(s):  
Ilka Isfort ◽  
Sandra Elges ◽  
Magdalene Cyra ◽  
Danielle Brandes ◽  
Ruth Berthold ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Tumors ◽  
Hippo Pathway ◽  
Transcriptional Coactivators

scholarly journals The transcriptional coactivators Yap and TAZ are expressed during early Xenopus development

2011 ◽  
Vol 55 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Susumu Nejigane ◽  
Yoshikazu Haramoto ◽  
Makoto Okuno ◽  
Shuji Takahashi ◽  
Makoto Asashima
Keyword(s):  
Xenopus Development ◽  
Transcriptional Coactivators

scholarly journals Regulation of myocardin-related transcriptional coactivators through cofactor interactions in differentiation and cancer

Cell Cycle ◽  
2009 ◽  
Vol 8 (16) ◽  
pp. 2523-2527 ◽  
Author(s):  
Dominique T. Brandt ◽  
Jianming Xu ◽  
Herbert Steinbeisser ◽  
Robert Grosse
Keyword(s):  
Transcriptional Coactivators

scholarly journals Interaction of PIMT with Transcriptional Coactivators CBP, p300, and PBP Differential Role in Transcriptional Regulation

2002 ◽  
Vol 277 (22) ◽  
pp. 20011-20019 ◽  
Author(s):  
Parimal Misra ◽  
Chao Qi ◽  
Songtao Yu ◽  
Sejal H. Shah ◽  
Wen-Qing Cao ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Transcriptional Coactivators
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