Regulation of S-Adenosylmethionine Decarboxylase

2006 ◽  
pp. 449-464
Author(s):  
Colin Hanfrey
Keyword(s):  
Adenosylmethionine Decarboxylase

scholarly journals Overexpression of arginine decarboxylase in transgenic plants

1997 ◽  
Vol 325 (2) ◽  
pp. 331-337 ◽  
Author(s):  
Daniel BURTIN ◽  
Anthony J. MICHAEL
Keyword(s):  
Transgenic Plants ◽  
Arginine Decarboxylase ◽  
Polyamine Metabolism ◽  
Morphological Development ◽  
Polyamine Biosynthesis ◽  
Adenosylmethionine Decarboxylase ◽  
Two Generations ◽  
Key Enzyme ◽  
Polyamine Conjugate ◽  
And Control

The activity of arginine decarboxylase (ADC), a key enzyme in plant polyamine biosynthesis, was manipulated in two generations of transgenic tobacco plants. Second-generation transgenic plants overexpressing an oat ADC cDNA contained high levels of oat ADC transcript relative to tobacco ADC, possessed elevated ADC enzyme activity and accumulated 10–20-fold more agmatine, the direct product of ADC. In the presence of high levels of the precursor agmatine, no increase in the levels of the polyamines putrescine, spermidine and spermine was detected in the transgenic plants. Similarly, the activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase were unchanged. No diversion of polyamine metabolism into the hydroxycinnamic acid–polyamine conjugate pool or into the tobacco alkaloid nicotine was detected. Activity of the catabolic enzyme diamine oxidase was the same in transgenic and control plants. The elevated ADC activity and agmatine production were subjected to a metabolic/physical block preventing increased, i.e. deregulated, polyamine accumulation. Overaccumulation of agmatine in the transgenic plants did not affect morphological development.

scholarly journals Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma

2009 ◽  
Vol 8 (7) ◽  
pp. 2067-2075 ◽  
Author(s):  
Dana-Lynn T. Koomoa ◽  
Tamas Borsics ◽  
David J. Feith ◽  
Craig C. Coleman ◽  
Christopher J. Wallick ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase B ◽  
Polyamine Metabolism ◽  
Adenosylmethionine Decarboxylase

scholarly journals Structure and regulation of mammalian S-adenosylmethionine decarboxylase.

1988 ◽  
Vol 263 (32) ◽  
pp. 17040-17049 ◽  
Author(s):  
A Pajunen ◽  
A Crozat ◽  
O A Jänne ◽  
R Ihalainen ◽  
P H Laitinen ◽  
...  
Keyword(s):  
Adenosylmethionine Decarboxylase
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