Endoscopic Screening for Squamous Cell Carcinoma of the Esophagus

Pericardial effusions leading to cardiac tamponade have previously been described with esophageal cancer. However, up to eighty percent of these cases have been reported in association with chemotherapy and radiation. Patients with esophageal cancer seldom initially present with pericardial effusion resulting from esophageal pericardial fistula (EPF). Herein, we present the case of a 62-year-old man who presented with pericardial effusion with an unknown etiology at presentation. Subsequently, the patient developed cardiac tamponade and was referred to the tertiary hospital for further evaluation. Computed tomography of the chest revealed a circumferential irregular enhancing lesion at the mid-thoracic esophagus suspecting esophageal cancer with EPF and a moderate amount of pericardial effusion. The patient underwent esophagoscopy and squamous cell carcinoma was found from the esophageal biopsy. An esophageal stent was successfully placed to conceal the perforation. Eventually, the patient died 13 days after admission complicated by refractory septic shock. This case highlights an atypical presentation of esophageal cancer and an unusual cause of cardiac tamponade.

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Prevalence of squamous cell carcinoma of the esophagus in a single tertiary center of South Africa: a cross sectional analytic study

Journal of Public Health in Africa ◽

10.4081/jphia.2017.563 ◽

2017 ◽

Vol 8 (1) ◽

Cited By ~ 1

Author(s):

Mpho Kgomo ◽

Ali A. Elnagar ◽

Jaco Nagel ◽

Taole Mokoena

Keyword(s):

South Africa ◽

Squamous Cell Carcinoma ◽

Esophageal Cancer ◽

Cell Carcinoma ◽

Squamous Cell ◽

The United States ◽

Upper Gastrointestinal Endoscopy ◽

Carcinoma Of The Esophagus ◽

Elderly Males ◽

Tertiary Center

The incidence of esophageal cancer varies widely in the world. In the Middle East, Africa, and Asia and parts of Europe, squamous cell carcinoma of the esophagus dominates the esophageal cancer landscape. Worldwide the rates are highest in Northern China, South Africa, Turkey and Iran. In the United States, the black population has a five-fold higher incidence of esophageal squamous cell carcinoma than the white population. To determine the prevalence of squamous cell carcinoma of the esophagus in a single tertiary center in South Africa. Patients referred to Gastroenterology Division of Steve Biko Academic Hospital for upper gastrointestinal endoscopy were recruited. Those with a known diagnoses of squamous cell carcinoma of the esophagus were recorded and those with suspicious lesions had biopsies done. These were then evaluated by an experienced histopathologist. 6118 patients were recruited. Squamous cell carcinoma was found in 59 patients giving us a prevalence of 0.96% 95%CI. The cancer was found mainly in back elderly males. The prevalence of squamous cell carcinoma of the esophagus in this single center study is 0.96%, 95% confidence interval and is a disease of black elderly males as seen elsewhere. Bigger multicenter studies are needed to further clarify this findings.

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Correction to: MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus

Journal of Translational Medicine ◽

10.1186/s12967-018-1513-8 ◽

2018 ◽

Vol 16 (1) ◽

Cited By ~ 1

Author(s):

Julia Slotta-Huspenina ◽

Enken Drecoll ◽

Marcus Feith ◽

Daniel Habermehl ◽

Stephanie E. Combs ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Expression Profiling ◽

Microrna Expression ◽

Neoadjuvant Radiochemotherapy ◽

Carcinoma Of The Esophagus

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A Preliminary Study on the Postoperative Survival of Patients Given Aspirin After Resection for Squamous Cell Carcinoma of the Esophagus or Adenocarcinoma of the Cardia

Annals of Surgical Oncology ◽

10.1245/s10434-009-0382-z ◽

2009 ◽

Vol 16 (5) ◽

pp. 1397-1402 ◽

Cited By ~ 29

Author(s):

Jun-Feng Liu ◽

Glyn G. Jamieson ◽

Tie-Cheng Wu ◽

Gui-Jun Zhu ◽

Paul A. Drew

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Postoperative Survival ◽

Carcinoma Of The Esophagus ◽

Preliminary Study

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Outcomes of lymphadenectomy for lymph node recurrence after esophagectomy or definitive chemoradiotherapy for squamous cell carcinoma of the esophagus

General Thoracic and Cardiovascular Surgery ◽

10.1007/s11748-014-0444-4 ◽

2014 ◽

Vol 62 (11) ◽

pp. 685-692 ◽

Cited By ~ 15

Author(s):

Masayuki Watanabe ◽

Shinji Mine ◽

Kazuhiko Yamada ◽

Hironobu Shigaki ◽

Yoshifumi Baba ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Cell Carcinoma ◽

Squamous Cell ◽

Definitive Chemoradiotherapy ◽

Carcinoma Of The Esophagus ◽

Lymph Node Recurrence

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PS02.232: BASALOID CARCINOMA OF THE ESOPHAGUS: MULTIMODAL APPROACH

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.232 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 188-188

Author(s):

Marta De Vega ◽

Carlos Miliani ◽

Juan Rodriguez Vitoria ◽

Juan Antonio Martinez-Piñeiro ◽

Fernando Pereira

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Multimodal Treatment ◽

Locally Advanced ◽

Distal Esophagus ◽

Lower Esophagus ◽

Carcinoma Of The Esophagus ◽

Basaloid Cell ◽

Poorly Differentiated

Abstract Background Basaloid cell carcinoma of the esophagus (BSCCE) is a rare (0.07–4%) poorly-differentiated variety of squamous cell carcinoma (SCC), more aggressive and with a worse prognosis than typical SCC. There are no published studies on the best therapeutic option for these tumors or on of the effectiveness of Neoadjuvant chemoradiotherapie; so there is no standard treatment. We describe the characteristics and the therapeutic strategy applied to a patient with an avanced basaloid squamous cell carcinoma of the distal esophagus. Methods A 70-year-old woman with dysphagia and severe malnutrition was diagnosed with locally advanced esophageal cáncer of lower esophagus The biopsy indicated moderately differentiated basaloid cell carcinoma. The clinical diagnosis was cT4NxM0, We decided multimodal treatment with curative intent: Neoadjuvant chemoradiotherapie at a dose of 41.4 Gy and concomitant carboplatin and pacliotaxel 5 cycles (CROSS scheme) plus surgery. Results PET-TAC post-neoadjuvant re-evaluation showed partial morphological response (reduction of tumor metabolism in 34.7%). 6 weeks after radiochemotherapy we performed a three fields total esophagectomy. Postoperative course without incidents. The pathological diagnosis was BASALOID cell CARCINOMA located in distal esophagus of 10 cm long with 30% tumor residual; it affects gastro-oesophageal junction. Stage TNM 7th ed: ypT3 N0 (0/17) L0V1R0 Our patient is fine and without evidence of recurrence after 15 meses. Conclusion Basal squamous cell carcinoma is more common in men around 60 years old, being rare in older women. They are located more frequently in the middle than in lower esophagus. They are tumors of poor prognosis (poorly differentiated, locally advanced and with an aggressive biological behavior that predisposes to early metastasis) although the latest publications relate the prognosis especially with the stage of the tumor. There are no published data about the use of Neoadjuvant treatment for these tumors. We have carried out a multimodal treatment (Cross scheme) followed by surgery with clinical, radiological (PET-TAC) and pathological response (30% of residual tumor in the piece) CONCLUSION The multimodal treatment with Cross scheme and surgery was useful in patients with Basaloid tumor of the esophagus can be considered for patients with this type of tumor. Disclosure All authors have declared no conflicts of interest.

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