Tumor-Targeted Salmonella typhimurium Overexpressing Cytosine Deaminase: A Novel, Tumor-Selective Therapy

2009 ◽  
pp. 649-659 ◽  
Author(s):  
Ivan King ◽  
Martina Itterson ◽  
David Bermudes
Keyword(s):  
Salmonella Typhimurium ◽  
Cytosine Deaminase ◽  
Selective Therapy ◽  
Tumor Selective

scholarly journals Antitumour activity of Salmonella typhimurium VNP20047 in B16(F10) murine melanoma model.

2004 ◽  
Vol 51 (3) ◽  
pp. 851-856 ◽  
Author(s):  
Joanna Jazowiecka-Rakus ◽  
Stanisław Szala
Keyword(s):  
Salmonella Typhimurium ◽  
Inflammatory Responses ◽  
Antitumour Activity ◽  
Cytosine Deaminase ◽  
Initial Inoculum ◽  
Animal Survival ◽  
Inoculum Dose ◽  
Melanoma Model ◽  
Number Of Bacteria ◽  
Cytosine Deaminase Gene

A tumour therapy is proposed based on attenuated Salmonella typhimurium VNP20047 expressing the Escherichia coli cytosine deaminase gene. VNP20047 was administered intravenously to B16(F10) melanoma-bearing C57BL/6 mice. VNP20047 proliferated within tumours and livers regardless of the initial inoculum dose. After 10 days the number of bacteria increased in livers up to 4.2 x 10(6) cfu/g and decreased in tumours down to 5.9 x 10(6) cfu/g. VNP20047 at 1 x 10(5) cfu/mouse, when combined with 5-fluorocytosine, inhibited tumour growth by 85% without prolonging animal survival. Histology studies revealed severe lesions in tumours and livers. These data suggest that S. typhimurium VNP20047 induced inflammatory responses, even though the strain was attenuated.

Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing’s Sarcoma in a Patient-Derived Orthotopic Xenograft Model

Chemotherapy ◽  
2018 ◽  
Vol 63 (5) ◽  
pp. 278-283 ◽  
Author(s):  
Kentaro Miyake ◽  
Tasuku Kiyuna ◽  
Shukuan Li ◽  
Qinghong Han ◽  
Yuying Tan ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Salmonella Typhimurium ◽  
Cancer Metabolism ◽  
Tumor Volume ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Xenograft Model ◽  
Orthotopic Xenograft ◽  
Orthotopic Xenograft Model ◽  
Tumor Selective

Background: Ewing’s sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics. Objectives: The aim of this study was to investigate the efficacy of tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model. Methods: The ES PDOX models were previously established in the right chest wall. The ES PDOX models were randomized into 5 groups when the tumor volume reached 80 mm3: G1: untreated control; G2: doxorubicin; G3: S. typhimurium A1-R; G4: o-rMETase; G5: S. typhimurium A1-R combined with o-rMETase. All mice were sacrificed on day 15. Body weight and tumor volume were assessed twice a week. Results: S. typhimurium A1-R and o-rMETase respectively suppressed tumor growth as monotherapies (p = 0.050 and p = 0.032). S. typhimurium A1-R combined with o-rMETase regressed tumor growth significantly compared to untreated group on day 15 (p < 0.032). S. typhimurium A1-R combined with o-rMETase group was significantly more effective than S. typhimurium A1-R or o-rMETase monotherapy (p = 0.032, p = 0.032). Conclusions: The present results suggest that the combination of S. typhimurium A1-R and o-rMETase has promise to be a transformative therapy for ES.

Development of Prodrugs for Enzyme-Mediated, Tumor-Selective Therapy

2005 ◽  
Vol 5 (2) ◽  
pp. 107-113 ◽  
Author(s):  
K. Yoon ◽  
Philip Potter ◽  
Mary Danks
Keyword(s):  
Selective Therapy ◽  
Tumor Selective

NSC-mediated tumor selective therapy – towards glioma clinical trials

2008 ◽  
Vol 6 (9) ◽  
pp. 30
Author(s):  
K.S. Aboody ◽  
J. Najbauer ◽  
M.K. Danks ◽  
S.U. Kim ◽  
M.Z. Metz ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Selective Therapy ◽  
Tumor Selective

Design of tailor-made prodrugs for tumor-selective therapy

1995 ◽  
Vol 121 (S1) ◽  
pp. A51-A51
Author(s):  
K. -H. Glüsenkamp ◽  
C. Mengede ◽  
W. Drosdziok ◽  
R. Johnen ◽  
C. Krüsemann ◽  
...  
Keyword(s):  
Selective Therapy ◽  
Tumor Selective

Cell membrane camouflaged cerium oxide nanocubes for targeting enhanced tumor-selective therapy

2021 ◽  
Author(s):  
Zongjun Liu ◽  
Peng Wan ◽  
Mingxin Yang ◽  
Fang Han ◽  
Tianran Wang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cerium Oxide ◽  
Selective Therapy ◽  
Tumor Selective

Anticancer therapies with profound efficacy but negligible toxicity is a fundamental pursuit, which has been made humanly possible so far through either targeting or tumor-selective therapeutic (TST) approach. Herein, we...

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