Vascular Cognitive Impairment and Alzheimer Disease: Are These Disorders Linked to Hypertension and Other Cardiovascular Risk Factors?

2010 ◽  
pp. 195-210
Author(s):  
Fernando D. Testai ◽  
Philip B. Gorelick
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Alzheimer Disease ◽  
Cardiovascular Risk Factors ◽  
Vascular Cognitive Impairment

scholarly journals Association between ApoE ε4 Carrier Status and Cardiovascular Risk Factors on Mild Cognitive Impairment among Mexican Older Adults

2021 ◽  
Vol 11 (1) ◽  
pp. 68
Author(s):  
Sara G. Aguilar-Navarro ◽  
Itzel I. Gonzalez-Aparicio ◽  
José Alberto Avila-Funes ◽  
Teresa Juárez-Cedillo ◽  
Teresa Tusié-Luna ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Mild Cognitive Impairment ◽  
Cardiovascular Risk Factors ◽  
Apoe Genotype ◽  
Carrier Status ◽  
Apoe Ε4 ◽  
Increased Risk

Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer’s disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (n = 63 with normal cognition (NC), n = 24 with amnesic, and n = 50 with non-amnesic MCI). Multinomial logistic regression models were performed in order to determine the association between ApoE ε4 polymorphism carrier and CVRF on amnestic and non-amnestic-MCI. ApoE ε4 carrier status was present in 28.8% participants. The models showed that ApoE ε4 carrier status was not associated neither aMCI nor naMCI condition. The interaction term ApoE ε4 × CVRF was not statistically significant for both types of MCI. However, CVRF were associated with both types of MCI and the association remained statistically significant after adjustment by sex, age, and education level. The carrier status of the ApoE genotype does not contribute to this risk.

Midlife cardiovascular risk factors and late cognitive impairment

2013 ◽  
Vol 28 (5) ◽  
pp. 405-416 ◽  
Author(s):  
Jyri J. Virta ◽  
Kauko Heikkilä ◽  
Markus Perola ◽  
Markku Koskenvuo ◽  
Ismo Räihä ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors

Uric acid may be protective against cognitive impairment in older adults, but only in those without cardiovascular risk factors

2017 ◽  
Vol 89 ◽  
pp. 15-19 ◽  
Author(s):  
Busra Tuven ◽  
Pinar Soysal ◽  
Gulcin Unutmaz ◽  
Derya Kaya ◽  
Ahmet Turan Isik
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Uric Acid ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors

scholarly journals The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease

2016 ◽  
Vol 73 (10) ◽  
pp. 1231 ◽  
Author(s):  
Giuseppe Tosto ◽  
Thomas D. Bird ◽  
David A. Bennett ◽  
Bradley F. Boeve ◽  
Adam M. Brickman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Alzheimer Disease ◽  
Cardiovascular Risk Factors ◽  
Familial Alzheimer Disease

Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI)

2012 ◽  
Vol 54 (2) ◽  
pp. 330-332 ◽  
Author(s):  
E. Ettorre ◽  
E. Cerra ◽  
B. Marigliano ◽  
M. Vigliotta ◽  
A. Vulcano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cardiovascular Risk ◽  
Mild Cognitive Impairment ◽  
Cardiovascular Risk Factors
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