Photodynamic Therapy-Generated Cancer Vaccines

2010 ◽  
pp. 147-153 ◽  
Author(s):  
Mladen Korbelik
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Vaccines

scholarly journals Mreg Activity in Tumor Response to Photodynamic Therapy and Photodynamic Therapy-Generated Cancer Vaccines

Cancers ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 94 ◽  
Author(s):  
Mladen Korbelik ◽  
Judith Banáth ◽  
Wei Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Vaccines ◽  
Tumor Response

scholarly journals Immunoregulatory Cell Depletion Improves the Efficacy of Photodynamic Therapy-Generated Cancer Vaccines

2015 ◽  
Vol 16 (11) ◽  
pp. 27005-27014 ◽  
Author(s):  
Mladen Korbelik ◽  
Judit Banáth ◽  
Kyi Saw
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Vaccines ◽  
Cell Depletion

scholarly journals Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Jianfeng Hua ◽  
Pan Wu ◽  
Lu Gan ◽  
Zhikun Zhang ◽  
Jian He ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Immune Responses ◽  
Immune Suppression ◽  
Cancer Vaccines ◽  
Tumor Metastasis ◽  
Immune Checkpoint Blockade ◽  
Clinical Applications ◽  
Antitumor Therapy ◽  
Combination Strategies ◽  
Immune Adjuvants

Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer. Both therapies, on their own, have some limitations and are incapable of meeting the demands of the current cancer treatment. The efficacy of PDT and immunotherapy against tumor metastasis and tumor recurrence may be improved by combination strategies. In this review, we discussed the possibility that PDT could be used to activate immune responses by inducing immunogenic cell death or generating cancer vaccines. Furthermore, we explored the latest advances in PDT antitumor therapy in combination with some immunotherapy such as immune adjuvants, inhibitors of immune suppression, and immune checkpoint blockade.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

2020 ◽  
Vol 56 (43) ◽  
pp. 5819-5822
Author(s):  
Jing Zheng ◽  
Yongzhuo Liu ◽  
Fengling Song ◽  
Long Jiao ◽  
Yingnan Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Near Infrared ◽  
Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

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