Ethics of Modeling of Cerebral Ischemia in Small Animals

Arterial spin labeling in small animals: Methods and applications to experimental cerebral ischemia

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.20453 ◽

2005 ◽

Vol 22 (6) ◽

pp. 741-744 ◽

Cited By ~ 16

Author(s):

David L. Thomas

Keyword(s):

Cerebral Ischemia ◽

Arterial Spin Labeling ◽

Spin Labeling ◽

Small Animals ◽

Experimental Cerebral Ischemia

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Ethics of Modeling of Cerebral Ischemia in Small Animals

Neuromethods - Rodent Models of Stroke ◽

10.1007/978-1-4939-5620-3_17 ◽

2016 ◽

pp. 279-290

Author(s):

Ute Lindauer

Keyword(s):

Cerebral Ischemia ◽

Small Animals

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In vivo brain elasticity mapping in small animals using ultrasound and its application to cerebral ischemia

2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro ◽

10.1109/isbi.2010.5490369 ◽

2010 ◽

Cited By ~ 1

Author(s):

Emilie Mace ◽

Ivan Cohen ◽

Abraham Martin ◽

Gabriel Montaldo ◽

Mathias Fink ◽

...

Keyword(s):

Cerebral Ischemia ◽

Small Animals

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Ultrastorcture of Cerebellar Purkinje Cells in Rats Subjected To Partial Global Cerebral Ischemia

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120060 ◽

1985 ◽

Vol 43 ◽

pp. 674-675

Author(s):

R.V.W. Dimlich ◽

M.H. Biros

Keyword(s):

Cerebral Ischemia ◽

Purkinje Cells ◽

Cell Types ◽

Microscopic Level ◽

Global Cerebral Ischemia ◽

Light Microscopic Level ◽

Cerebellar Damage ◽

Cerebellar Injury ◽

Cerebellar Purkinje Cells ◽

Cell Changes

In severe cerebral ischemia, Purkinje cells of the cerebellum are one of the cell types most vulnerable to anoxic damage. In the partial (forebrain) global ischemic (PGI) model of the rat, Paljärvi noted at the light microscopic level that cerebellar damage is inconsistant and when present, milder than in the telencephalon, diencephalon and rostral brain stem. Cerebellar injury was observed in 3 of 4 PGI rats following 5 minutes of reperfusion but in none of the rats after 90 min of reperfusion. To evaluate a time between these two extremes (5 and 90 min), the present investigation used the PGI model to study the effects of ischemia on the ultrastructure of cerebellar Purkinje cells in rats that were sacrificed after 30 min of reperfusion. This time also was chosen because lactic acid that is thought to contribute to ischemic cell changes in PGI is at a maximum after 30 min of reperfusion.

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