Melanoma Susceptibility Genes and Risk Assessment

2013 ◽  
pp. 381-393 ◽  
Author(s):  
Alexander Marzuka-Alcalá ◽  
Michele Jacobs Gabree ◽  
Hensin Tsao
Keyword(s):  
Risk Assessment ◽  
Susceptibility Genes

scholarly journals Frequency of mutations in 21 hereditary breast and ovarian cancer susceptibility genes among high-risk Chinese individuals

2019 ◽  
Author(s):  
Di Shao ◽  
Shaomin Cheng ◽  
Fengming Guo ◽  
Yuying Yuan ◽  
Kunling Hu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Risk Assessment ◽  
High Risk ◽  
Cancer Susceptibility ◽  
Susceptibility Genes ◽  
Deleterious Mutations ◽  
Breast And Ovarian Cancer ◽  
Full Cohort ◽  
Cancer Susceptibility Genes ◽  
Multigene Panel

AbstractTo determine the prevalence and clinical prediction factors associated with deleterious mutations among 882 high-risk Chinese individuals who underwent multigene panel testing for hereditary breast and ovarian cancer (HBOC) risk assessment. Subjects were selected from individuals referred for genetic testing using a 21-gene panel (Oseq-BRCA) between January 2015 and March 2018. The distribution and prevalence of deleterious mutations were analyzed for the full cohort as well as subtypes. Overall, 176 deleterious mutations were observed in 19.50% (n = 172) individuals. Of these, 26 mutations are not reported in public databases and literatures. In the ovarian cancer only subgroup, 115 deleterious mutations were identified in 429 patients (48.6%). Patients with ovarian cancer with mutations were enriched for a family history of breast or ovarian cancers (p < 0.05). In the breast cancer only subgroup, 31 deleterious mutations were identified in 261 patients. Most mutations occurred inBRCA1(8; 25.8%) andBRCA2(11; 35.5%). An additional 12 deleterious mutations (38.7%) were found in 7 other susceptibility genes. An increased frequency of mutation rate (57.9%) was observed in the subgroup of subjects with histories of both breast and ovarian cancer. Taken together, 19.50% of individuals carried a deleterious mutation in HBOC susceptibility genes in our cohort. Subgroup of subjects with histories of both breast and ovarian cancer had the highest prevalence of mutations. Our results highlighted the genetic heterogeneity of HBOC and the efficiency of multigene panel in performing risk assessment.

Risk assessment in dentistry

1998 ◽  
Vol 62 (10) ◽  
pp. 756-761 ◽  
Author(s):  
CW Douglass
Keyword(s):  
Risk Assessment

1648: Multi-Institutional Validation of the UCSF Cancer of the Rostate Risk Assessment (CAPRA) for Prediction of Recurrence Following Radical Prostatectomy

2006 ◽  
Vol 175 (4S) ◽  
pp. 531-532
Author(s):  
Matthew R. Cooperberg ◽  
Stephen J. Freedland ◽  
David J. Pasta ◽  
Eric P. Elkin ◽  
Joseph C. Presti ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Radical Prostatectomy

New Questions on PAD Alter Framingham Risk Assessment

2006 ◽  
Vol 39 (17) ◽  
pp. 43
Author(s):  
BRUCE JANCIN
Keyword(s):  
Risk Assessment ◽  
Framingham Risk

Osteoporosis Guidelines Add Risk Assessment Tool

2008 ◽  
Vol 41 (10) ◽  
pp. 1-4
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Risk Assessment ◽  
Assessment Tool ◽  
Risk Assessment Tool
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