Principles of the Lymph Node Dissection in Non-melanoma Skin Cancer and Cutaneous Melanoma

Author(s):  
Steven D. Kozusko ◽  
Alireza Hamidian Jahromi ◽  
Grant Bond ◽  
Tyler D. Ragsdale ◽  
Robert D. Wallace ◽  
...  
2016 ◽  
Vol 130 (S2) ◽  
pp. S133-S141 ◽  
Author(s):  
O A Ahmed ◽  
C Kelly

AbstractThis is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the United Kingdom. This paper provides consensus recommendations on the management of melanomas arising in the skin and mucosa of the head and neck region on the basis of current evidence.Recommendations• At-risk individuals should be warned about the correlation between ultraviolet radiation (UVR) exposure and skin cancer, and should be given advice on UVR protection. (R)• Dermatoscopy can aid in the diagnosis of cutaneous melanoma. (R)• Histological examination after biopsy is essential to confirm the diagnosis and the tumour thickness. (G)• Excisional biopsy is method of choice. (G)• Staging investigations can be performed for both regional and distant disease. (R)• Scanning (computed tomography (CT) and/or magnetic resonance imaging) is recommended for patients with high-risk melanoma. (G)• Patients with signs or symptoms of disease relapse should be investigated by imaging. (R)• Imaging of the brain should be performed in patients who have stage IV disease. (G)• Patients with melanoma of unknown primary should be thoroughly examined and investigated for a potential primary source. (R)• Primary cutaneous invasive melanoma should be excised with a surgical margin of at least 1 cm. (G)• The maximum recommended excision margin is 3 cm. (R)• The actual margin of excision depends upon the depth of the melanoma and its anatomical site. (G)• Ultrasound-guided fine needle aspiration (FNA) or core biopsy of suspected lymphadenopathy is more accurate than ‘blind’ biopsy. (R)• Open biopsy should only be performed if FNA or core biopsy is inadequate or equivocal. (R)• Prior to lymph node dissection, staging by CT scan should be carried out. (R)• If parotid disease is present without neck involvement, both parotidectomy and neck dissection should ideally be performed. (R)• There is no role for elective lymph node dissection. (R)• Sentinel lymph node biopsy (SLNB) can be considered in stage IB and above by specialist skin cancer multidisciplinary teams. (G)• Patients should be made aware that SLNB is a staging procedure, and should understand that it has, as yet, no proven therapeutic value. (R)• All patients with cutaneous melanoma should have their original tumour checked for BRAF gene status, and their subsequent targeted biological therapy based on this. (R)• Patients who develop brain metastases should be considered for stereotactic radio-surgery. (R)


2013 ◽  
Vol 11 (1) ◽  
pp. 36 ◽  
Author(s):  
Nicola Mozzillo ◽  
Corrado Caracò ◽  
Ugo Marone ◽  
Gianluca Di Monta ◽  
Anna Crispo ◽  
...  

1993 ◽  
Vol 3 (1) ◽  
pp. 102
Author(s):  
V. Reynolds ◽  
S. Thellman ◽  
J. Delozier III ◽  
R. Shack ◽  
D. Page ◽  
...  

Author(s):  
Othon Papadopoulos ◽  
Fotios-Filippos Karantonis ◽  
Nikolaos A. Papadopulos

Author(s):  
Athanassios Kyrgidis ◽  
Thrasivoulos Tzellos ◽  
Simone Mocellin ◽  
Zoe Apalla ◽  
Aimilios Lallas ◽  
...  

2015 ◽  
Author(s):  
Jennifer A. Wargo ◽  
Kenneth Tenabe

The prevalence of malignant skin cancers has increased significantly over the past several years. Approximately 1.2 million cases of non-melanoma skin cancer are diagnosed per year. More alarming, up to 80,000 cases of melanoma are diagnosed per year, an incidence that has been steadily increasing, with a lifetime risk of 1 in 50 for the development of melanoma. The disturbing increase in the incidence of both non-melanoma skin cancer and melanoma can largely be attributed to the social attitude toward sun exposure. The clinical assessment and management of skin lesions can be challenging. This review describes the assessment process, including thorough history and examination; the need for possible biopsy; and excision criteria. Specific types of skin cancer are distinguished and include basal cell carcinoma; squamous cell carcinoma; and melanoma; and for each type the incidence; epidemiology; histologic subtypes; diagnosis; and both surgical and non-surgical treatments are provided. Stages I-IV of melanoma are detailed, with prognostic factors described. Surgical treatment for stages I and II include description of the margins of excision and sentinel lymph node biopsy. The surgical treatment of Stage III melanoma further includes therapeutic lymph node dissection and isolated limb perfusion. Adjuvant therapies are also presented and include radiotherapy and chemotherapy. The additional treatment of metastasectomy for Stage IV melanoma is described. For both Stage III and IV melanoma, the study of vaccines to host immune cells is reported. For Stage IV melanoma, the text also describes immunotherapy treatment. Operative procedures specific to superficial and deep groin dissections are outlined. This review contains 9 figures, 3 tables, and 96 references.


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