Right Ventricular End-Diastolic Volume Index

AbstractVentricular septal defects – large, surgically closed or small, untreated – have demonstrated lower peak exercise capacity compared with healthy controls. The mechanisms behind these findings are not yet fully understood. Therefore, we evaluated biventricular morphology in adults with a ventricular septal defect using MRI. Adults with either childhood surgically closed or small, untreated ventricular septal defects and healthy controls underwent cine MRI for the evaluation of biventricular volumes and quantitative flow scans for measurement of stroke index. Scans were analysed post hoc in a blinded manner. In total, 20 operated patients (22±2 years) and 20 healthy controls (23±2 years) were included, along with 32 patients with small, unrepaired ventricular septal defects (26±6 years) and 28 controls (27±5 years). Operated patients demonstrated larger right ventricular end-diastolic volume index (103±20 ml/m2) compared with their controls (88±16 ml/m2), p=0.01. Heart rate and right ventricular stroke index did not differ between operated patients and controls. Patients with unrepaired ventricular septal defects revealed larger right ventricular end-diastolic volume index (105±17 ml/m2) compared with their controls (88±13 ml/m2), p<0.01. Furthermore, right ventricular stroke index was higher in unrepaired ventricular septal defects (53±12 ml/minute/m2) compared with controls (46±8 ml/minute/m2), p=0.02, with similar heart rates. Both patient groups’ right ventricles were visually characterised by abundant coarse trabeculation. Positive correlations were demonstrated between right ventricular end-diastolic volume indices and peak exercise capacity in patients. Left ventricle measurements displayed no differences between groups. In conclusion, altered right ventricular morphology was demonstrated in adults 20 years after surgical ventricular septal defect repair and in adults with small, untreated ventricular septal defects.

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Right Ventricular End-Diastolic Volume Index as a Predictor of Preload Status in Patients With Low Right Ventricular Ejection Fraction During Orthotopic Liver Transplantation

Transplantation Proceedings ◽

10.1016/j.transproceed.2005.06.100 ◽

2005 ◽

Vol 37 (6) ◽

pp. 2541-2543 ◽

Cited By ~ 15

Author(s):

A. Siniscalchi ◽

M. Pavesi ◽

E. Piraccini ◽

L. De Pietri ◽

V. Braglia ◽

...

Keyword(s):

Liver Transplantation ◽

Ejection Fraction ◽

Right Ventricular ◽

Orthotopic Liver Transplantation ◽

Right Ventricular Ejection Fraction ◽

Ventricular Ejection ◽

Volume Index ◽

Ventricular Ejection Fraction ◽

End Diastolic Volume

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Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure

Critical Care Medicine ◽

10.1097/00003246-199811000-00017 ◽

1998 ◽

Vol 26 (11) ◽

pp. 1801-1806 ◽

Cited By ~ 104

Author(s):

Michael L. Cheatham ◽

Loren D. Nelson ◽

Michael C. Chang ◽

Karen Safcsak

Keyword(s):

Right Ventricular ◽

Volume Index ◽

Positive End Expiratory Pressure ◽

End Diastolic Volume

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Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect

Journal of Interventional Cardiology ◽

10.1155/2020/9509105 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Rie Nakayama ◽

Yoichi Takaya ◽

Teiji Akagi ◽

Koji Nakagawa ◽

Nobuhisa Watanabe ◽

...

Keyword(s):

Right Ventricular ◽

Atrial Septal Defect ◽

Exercise Capacity ◽

Septal Defect ◽

Adult Patients ◽

Volume Index ◽

End Diastolic Volume ◽

The Mean ◽

Asd Closure ◽

The Relationship

Objective. The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure. Background. RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation. Methods. We enrolled 82 consecutive patients (mean age, 49 ± 18 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. The relationship between RV volume and peak oxygen uptake (VO2) was evaluated. Results. The mean RV end-diastolic volume index was 108 ± 27 ml/m2 (range, 46 to 180 ml/m2). The mean peak VO2 was 24 ± 7 ml/min/kg (range, 14 to 48 ml/min/kg), and the mean predicted peak VO2 was 90 ± 23%. There were significant negative relationships of RV end-diastolic volume index with peak VO2 (r = −0.28, p<0.01) and predicted peak VO2 (r = −0.29, p<0.01). The cutoff value of RV end-diastolic volume index <80% of predicted peak VO2 was 120 ml/m2, with the sensitivity of 49% and the specificity of 89%. Conclusions. There was a relationship between RV dilatation and exercise capacity in adult patients with ASD. RV end-diastolic volume index ≥120 ml/m2 was related to the reduction in peak VO2. This criterion of RV dilatation may be valuable for the indication of transcatheter ASD closure.

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P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis

European Heart Journal ◽

10.1093/eurheartj/ehz747.0145 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

C Czimbalmos ◽

I Csecs ◽

Z Dohy ◽

A Toth ◽

F I Suhai ◽

...

Keyword(s):

Ejection Fraction ◽

Diagnostic Accuracy ◽

Right Ventricular ◽

Task Force ◽

Arrhythmogenic Right Ventricular Cardiomyopathy ◽

Strain Analysis ◽

Volume Index ◽

Ventricular Cardiomyopathy ◽

End Diastolic Volume ◽

Regional Strain

Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a major cause of sudden cardiac death in young athletes. However diagnosing ARVC in highly trained athletes may be complicated because of overlapping features such as elevated right ventricular (RV) end-diastolic volume index or T-wave inversion in precordial leads. The revised Task Force criteria contain no specific cut-off value for professional athletes. Additional CMR parameters and CMR deformation imaging may have an added diagnostic value in this special patient population. Our goal was to determine novel CMR parameters which can help to distinguish between ARVC and athlete's heart. CMR examination of ARVC patients with definite diagnosis based on the revised Task Force criteria (n=34; 41±13 y, 22 male) and healthy professional athletes (members of the Hungarian national water polo, canoing or rowing team performing minimum of 15 hours of training per week, n=34, 32±6 y, 22 male) was performed. We evaluated left and right ventricular end-systolic, end-diastolic (EDVi) and stroke volume index, ejection fraction (EF) and mass. We established derived parameters such as ejection fraction ratio (LVEF/RVEF) and end-diastolic volume ratio (LVEDV/RVEDV). Global and regional strain analysis for the right ventricle was performed using feature tracking technique. Area under the ROC curves (AUC) of conventional and derived CMR parameters and CMR based strain values were analysed. There was no significant difference between RVEDVi of ARVC patients and athletes (124±17 vs 142±47), RVEF was lower in ARVC patients compared to athletes (56±5 vs 41±14%; p<0.001). Significant differences were found between athletes and ARVC patients in LVEDV/RVEDV (0.96±0.08 vs 0.82±0.23), LVEF/RVEF (1.04±0.06 vs 1.41±0.56), global circumferential strain (−34.8±5.9 vs −25.2±12.2) and regional strain values such as midventricular RV strain (−31.5±10.2 vs −20.0±13.4) or midventricular RV strain rate (−1.37±0.56 vs −1.04±0.68), respectively. RVEF and LVEF/RVEF showed excellent (AUC of 0.9–1.0), RV global strain and RV midventricular strain values showed good diagnostic accuracy (AUC of 0.8–0.9), while RVEDVi showed poor diagnostic accuracy (AUC of 0.59). Consequently, in highly trained healthy athletes RVEDVi is in the range of major Task Force criteria, while CMR based derived parameters such as LVEDV/RVEDV or LVEF/RVEF and both global and regional RV strain parameters can be useful parameters in the differential diagnosis. Acknowledgement/Funding National Research, Development and Innovation Office (NKFIH) of Hungary (K 120277), ÚNKP-18-3-IV New National Excellence Program of Human Capacities.

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Reproducibility and correlations of right ventricular end-diastolic volume index measured by real-time three-dimensional echocardiography

Journal of Clinical Ultrasound ◽

10.1002/jcu.22092 ◽

2013 ◽

Vol 42 (2) ◽

pp. 81-88 ◽

Cited By ~ 1

Author(s):

Yingjia Xu ◽

Weihua Wu ◽

Weiyi Fang ◽

Hui Chen

Keyword(s):

Right Ventricular ◽

Real Time ◽

Three Dimensional ◽

Volume Index ◽

End Diastolic Volume ◽

Dimensional Echocardiography ◽

Three Dimensional Echocardiography

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Does Predictors of Preload Measured from Continuous Right Ventricular End-diastolic Volume Index Monitored Pulmonary Artery Catheter Reflect Stroke Volume Index in Off Pump Coronary Artery Bypass?

Korean Journal of Anesthesiology ◽

10.4097/kjae.2007.53.2.206 ◽

2007 ◽

Vol 53 (2) ◽

pp. 206

Author(s):

Ji Yeon Lee ◽

Sou Ouk Bang ◽

Jae Kwang Shim ◽

Jong Hwa Lee ◽

Young Ju Won ◽

...

Keyword(s):

Coronary Artery ◽

Pulmonary Artery ◽

Stroke Volume ◽

Right Ventricular ◽

Artery Bypass ◽

Stroke Volume Index ◽

Volume Index ◽

Off Pump ◽

End Diastolic Volume ◽

Pump Coronary Artery Bypass

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Effects of milrinone and epinephrine or dopamine on biventricular function and hemodynamics in right heart failure after pulmonary regurgitation

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00384.2015 ◽

2015 ◽

Vol 309 (5) ◽

pp. H860-H866 ◽

Cited By ~ 2

Author(s):

Janus Adler Hyldebrandt ◽

Peter Agger ◽

Eleonora Sivén ◽

Kristian Borup Wemmelund ◽

Johan Heiberg ◽

...

Keyword(s):

Right Ventricular ◽

Venous Pressure ◽

Interventricular Septum ◽

Pulmonary Regurgitation ◽

Stroke Volume Index ◽

Right Heart Failure ◽

Volume Index ◽

Control Group ◽

Dependent Manner ◽

End Diastolic Volume

Right ventricular failure (RVF) secondary to pulmonary regurgitation (PR) impairs right ventricular (RV) function and interrupts the interventricular relationship. There are few recommendations for the medical management of severe RVF after prolonged PR. PR was induced in 16 Danish landrace pigs by plication of the pulmonary valve leaflets. Twenty-three pigs served as controls. At reexamination the effect of milrinone, epinephrine, and dopamine was evaluated using biventricular conductance and pulmonary catheters. Seventy-nine days after PR was induced, RV end-diastolic volume index (EDVI) had increased by 33% ( P = 0.006) and there was a severe decrease in the load-independent measurement of contractility (PRSW) (−58%; P = 0.003). Lower cardiac index (CI) (−28%; P < 0.0001), mean arterial pressure (−15%; P = 0.01) and mixed venous oxygen saturation (SvO2) (36%; P < 0.0001) were observed compared with the control group. The interventricular septum deviated toward the left ventricle (LV). Milrinone improved RV-PRSW and CI and maintained systemic pressure while reducing central venous pressure (CVP). Epinephrine and dopamine further improved biventricular PRSW and CI equally in a dose-dependent manner. Systemic and pulmonary pressures were higher in the dopamine-treated animals compared with epinephrine-treated animals. None of the treatments improved stroke volume index (SVI) despite increases in contractility. Strong correlation was detected between SVI and LV-EDVI, but not SVI and biventricular contractility. In RVF due to PR, milrinone significantly improved CI, SvO2, and CVP and increased contractility in the RV. Epinephrine and dopamine had equal inotropic effect, but a greater vasopressor effect was observed for dopamine. SV was unchanged due to inability of both treatments to increase LV-EDVI.

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