The Role of Hysteroscopy in Diagnosis and Management of Recurrent Pregnancy Loss (RPL)

2020 ◽  
pp. 171-177
Author(s):  
Marco Gergolet ◽  
Michael Kamrava
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Diagnosis And Management

Investigating the role of EGF-CFC gene family in recurrent pregnancy loss through bioinformatics and molecular approaches

2021 ◽  
pp. 1-13
Author(s):  
João Matheus Bremm ◽  
Juliano André Boquett ◽  
Marcus Silva Michels ◽  
Thayne Woycinck Kowalski ◽  
Flávia Gobetti Gomes ◽  
...  
Keyword(s):  
Gene Family ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Molecular Approaches

Role of male genetic factors in recurrent pregnancy loss in Northeast China

2018 ◽  
Vol 224 ◽  
pp. 6-11 ◽  
Author(s):  
Rulin Dai ◽  
Yuan Pan ◽  
Yan Fu ◽  
Qian Liu ◽  
Weifeng Han ◽  
...  
Keyword(s):  
Northeast China ◽  
Pregnancy Loss ◽  
Genetic Factors ◽  
Recurrent Pregnancy Loss

scholarly journals Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss

2018 ◽  
Vol 6 (4) ◽  
pp. 98 ◽  
Author(s):  
Fatemeh Karami ◽  
Maliheh Askari ◽  
Mohammad Modarressi
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Human Platelets ◽  
P Value ◽  
Increased Risk ◽  
History Of ◽  
Polymerase Chain ◽  
Β Chain ◽  
Larger Sample

Thrombophilia gene variants have been shown to be associated with higher risk of recurrent pregnancy loss (RPL). Due to the role of human platelets antigen 1 (HPA-1) and fibrinogen β chain (FGB) as critical players in the coagulation process, their most important variants including rs5918 T > C and rs1800790 G > A were selected to be studied in women affected by RPL. Three milliliters of peripheral blood were drawn from 110 women with history of at least two consecutive spontaneous abortion and 110 healthy women controls. rs5918 T > C and rs1800790 G > A of HPA-1 and FGB genes, respectively, were selected to be analyzed through polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) following DNA isolation using QIAamp DNA Blood Mini Kit. Heterozygote genotype (TC) of HPA-1 gene rs5918 polymorphism was significantly associated with risk of RPL (p-value = 0.02). Although, rs1800790 G > A of FGB gene was not associated with RPL, its combination with rs5918 polymorphism was associated with increased risk of RPL. Owing to the critical roles of FGB and HPA-1 genes in coagulation, and thrombosis and several confinements on the meaningful association between the combination of those polymorphism with risk of RPL, including them in the thrombophilia panel may increase detection rate of hereditary thrombophilia patients. However, further studies with larger sample sizes are required to shed light on the exact role of the studied gene polymorphism, especially rs1800790 G > A of FGB gene variant in pathogenesis of RPL.

scholarly journals Endometrial evaluation with methylene blue staining in patients with normal hysteroscopy

2019 ◽  
Vol 8 (7) ◽  
pp. 2715
Author(s):  
Alka Goel ◽  
Pooja Gupta ◽  
Akansha Singh ◽  
Khushboo Singh
Keyword(s):  
Methylene Blue ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Blue Staining ◽  
False Negatives ◽  
Normal Endometrium ◽  
Significant Difference ◽  
History Of ◽  
Dark Blue

Background: Normally, endometrium comprises of non-absorptive epithelium and does not take up stain. Conventional staining with methylene blue is explained on the basis of existence of apoptotic cells in endometrium.Methods: Of 50 patients of unexplained infertility, AUB, recurrent pregnancy loss were randomly selected and included in the study. Those with abnormal ultrasound and history of tuberculosis were excluded. Conventional hysteroscopy was performed using normal saline as distending medium and in those with grossly normal endometrium were subjected to staining with 5% methylene blue instilled trans cervically. After 5 min, irrespective of the size and pattern, focal dark blue stained areas were considered abnormal and randomly biopsied. Incidence of endometritis in both groups was compared after histopathological examination.Results: Of total 50 patients, histopathological report of only one patient with dark blue staining had evidence of endometritis. Rest had no evidence, of which 73.5% had light blue or unstained areas and 26.5% showed dark blue staining. No statistically significant difference was found between histopathological reports and light or dark blue staining (p=0.28). When percentage stained area was considered more than 50% only to be positive, sensitivity was 100%, specificity 94%, PPV 25% and NPV 100%. False positives were 75% and no false negatives were observed. Although p values improved but still statistically insignificant.Conclusions: Present study failed to establish any significant correlation between staining pattern and detection rate of endometritis. With no Indian studies published on chromohysteroscopy so far, role of methylene blue in detection of subtle endometrial changes in modern gynaecology in Indian subpopulation is yet to be established.

scholarly journals LEUKEMIA INHIBITORY FACTOR IN RECURRENT PREGNANCY LOSS: IS THERE ANY ROLE OF LIFESTYLE INTERVENTION?

2020 ◽  
Vol 114 (3) ◽  
pp. e195
Author(s):  
Vidhu Dhawan ◽  
Neena Malhotra ◽  
Neeta Singh ◽  
Vatsla Dadhwal ◽  
Rima Dada
Keyword(s):  
Lifestyle Intervention ◽  
Leukemia Inhibitory Factor ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Inhibitory Factor
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