Principles of Mathematical Modeling in Biomedical Sciences: An Unwritten Gospel of Andrei Yakovlev

Chronobiological data: advantages of telemetric monitoring and prospects of mathematical modeling

ITM Web of Conferences ◽

10.1051/itmconf/20203101001 ◽

2020 ◽

Vol 31 ◽

pp. 01001

Author(s):

Mikhail L. Blagonravov ◽

Björn Lemmer ◽

Anna A. Bryk ◽

Vyacheslav A. Goryachev ◽

Abdukayum A. Karimov ◽

...

Keyword(s):

Mathematical Modeling ◽

Blood Pressure ◽

Heart Rate ◽

Light Exposure ◽

Bright Light ◽

Biological Rhythms ◽

Male Rats ◽

Shr Rats ◽

Biomedical Sciences ◽

Wistar Kyoto

Chronobiology and chronomedicine is a special part of biomedical sciences studying rhythmical patterns in physiological and pathological processes. In order to analyse probability of some pathology and to make forecasts concerning possibility of some diseases based on the signs of rhythmicity disorders it is necessary to perform continuous monitoring of different physiological functions for a certain period of time. Since 1984 until now we have had an excellent opportunity of studying biological rhythms and their disorders in animals using the method of radio-telemetric monitoring. A huge amount of continuous data obtained in telemetric monitoring could be used for mathematical modeling of different pathological processes on the basis of rhythmic patterns. In this work we have presented some preliminary results of the chronobiological study in which the effects of bright light on blood pressure and heart rate were investigated. The experiment was carried out on male rats of genetic strains: Wistar-Kyoto – normotensive rats and SHR – spontaneously hypertensive rats. The animals were exposed to 1 hour exposure of ∼ 10000 lux white LED light from 10.00 to 11.00 a.m. For the analysis of daily profiles of blood pressure and heart rate we used the method of radio-telemetric monitoring of blood pressure and heart rate. It was shown that systolic blood pressure significantly increased in both Wistar-Kyoto and SHR rats under the action of bright during the time of bright light exposure (from 10.00 to 11.00 a.m.) and within the whole daytime period. For SHR rats an increase in diastolic blood pressure during the period of bright light action was also typical. But there were no significant changes in heart rate in the animals of either strain. These results require further and more detailed chronobiological studies to provide additional evidence. However traditional statistical methods seem to be important but not sufficient for further investigations. Moreover we could lose a considerable part of data without using contemporary methods of computer and mathematical modeling.

Download Full-text