Insulin-dependent Non-canonical Activation of Notch in Drosophila: A Story of Notch-Induced Muscle Stem Cell Proliferation

2020 ◽  
pp. 131-144 ◽  
Author(s):  
Rajaguru Aradhya ◽  
Krzysztof Jagla
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Muscle Stem Cell ◽  
Stem Cell Proliferation ◽  
Insulin Dependent

Dynamics of cardiomyocyte and muscle stem cell proliferation in pig

2020 ◽  
Vol 388 (2) ◽  
pp. 111854
Author(s):  
Binxu Yin ◽  
Hongyan Ren ◽  
Hao Cai ◽  
Yunqi Jiang ◽  
Shuhong Zhao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Muscle Stem Cell ◽  
Stem Cell Proliferation

scholarly journals Intracellular Inactivation of Thyroid Hormone Is a Survival Mechanism for Muscle Stem Cell Proliferation and Lineage Progression

2014 ◽  
Vol 20 (6) ◽  
pp. 1038-1048 ◽  
Author(s):  
Monica Dentice ◽  
Raffaele Ambrosio ◽  
Valentina Damiano ◽  
Annarita Sibilio ◽  
Cristina Luongo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Thyroid Hormone ◽  
Muscle Stem Cell ◽  
Stem Cell Proliferation ◽  
Survival Mechanism

scholarly journals Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs

2019 ◽  
Vol 116 (23) ◽  
pp. 11285-11290 ◽  
Author(s):  
Dounia Abbadi ◽  
Ming Yang ◽  
Devon M. Chenette ◽  
John J. Andrews ◽  
Robert J. Schneider
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cell Fate ◽  
Satellite Cell ◽  
Mrna Decay ◽  
Muscle Development ◽  
Myoblast Differentiation ◽  
Muscle Stem Cell ◽  
Stem Cell Proliferation ◽  
Shh Pathway

AUF1 promotes rapid decay of mRNAs containing 3′ untranslated region (3′UTR) AU-rich elements (AREs). AUF1 depletion in mice accelerates muscle loss and causes limb girdle muscular dystrophy. Here, we demonstrate that the selective, targeted degradation by AUF1 of key muscle stem cell fate-determining checkpoint mRNAs regulates each stage of muscle development and regeneration by reprogramming each myogenic stage. Skeletal muscle stem (satellite) cell explants show that Auf1 transcription is activated with satellite cell activation by stem cell regulatory factor CTCF. AUF1 then targets checkpoint ARE-mRNAs for degradation, progressively reprogramming the transcriptome through each stage of myogenesis. Transition steps in myogenesis, from stem cell proliferation to differentiation to muscle fiber development, are each controlled by fate-determining checkpoint mRNAs, which, surprisingly, were found to be controlled in their expression by AUF1-targeted mRNA decay. Checkpoint mRNAs targeted by AUF1 include Twist1, decay of which promotes myoblast development; CyclinD1, decay of which blocks myoblast proliferation and initiates differentiation; and RGS5, decay of which activates Sonic Hedgehog (SHH) pathway-mediated differentiation of mature myotubes. AUF1 therefore orchestrates muscle stem cell proliferation, self-renewal, myoblast differentiation, and ultimately formation of muscle fibers through targeted, staged mRNA decay.

Sign in / Sign up

Export Citation Format

Share Document