Environmental Metabolomics: With the Perspective of Marine Toxicology Assessment

2020 ◽  
pp. 197-225
Author(s):  
Ninian Prem Prashanth Pabbathi ◽  
Neelam M. Nathani ◽  
Indra Ramjibhai Gadhvi ◽  
Mootapally Chandrashekar
Keyword(s):  
Environmental Metabolomics ◽  
Toxicology Assessment

Pharmacokinetic and toxicology assessment of INTERCEPT (S-59 and UVA treated) platelets

2001 ◽  
Vol 20 (10) ◽  
pp. 533-550 ◽  
Author(s):  
V Ciaravino ◽  
T McCullough ◽  
A D Dayan
Keyword(s):  
Ex Vivo ◽  
Reproductive Toxicity ◽  
In Vivo Studies ◽  
Pathogen Inactivation ◽  
Platelet Concentrates ◽  
Baxter Healthcare ◽  
Safety Margins ◽  
Toxicology Assessment

The pathogen inactivation process developed by Cerus and Baxter Healthcare Corporations uses the psoralen, S-59 (amotosalen) in an ex vivo photochemical treatment (PCT) process to inactivate viruses, bacteria, protozoans, and leukocytes in platelet concentrates and plasma. Studies were performed by intravenous infusion of S-59 PCT formulations-compound adsorption device (CAD) treatment and with non-UVA illuminated S-59, using doses that were multiples of potential clinical exposures. The studies comprised full pharmacokinetic, single and repeated-dose (up to 13 weeks duration) toxicity, safety pharmacology (CNS, renal, and cardiovascular), reproductive toxicity, genotoxicity, carcinogenicity testing in the p53- mouse, vein irritation, and phototoxicity. No specific target organ toxicity (clinical or histopathological), reproductive toxicity, or carcinogenicity was observed. S-59 and/or PCT formulations demonstrated CNS, ECG, and phototoxicity only at supraclinical doses. Based on the extremely large safety margins (>30,000 fold expected clinical exposures), the CNS and ECG observations are not considered to have any toxicological relevance. Additionally, after a complete assessment, mutagenicity and phototoxicity results are not considered relevant for the proposed use of INTERCEPT platelets. Thus, the results of an extensive series of in vitro and in vivo studies have not demonstrated any toxicologically relevant effects of platelet concentrates prepared by the INTERCEPT system.

Oxidative removal of phenol by HRP-immobilized beads and its environmental toxicology assessment

2016 ◽  
Vol 130 ◽  
pp. 234-239 ◽  
Author(s):  
Shuai Wang ◽  
He Fang ◽  
Xiaofeng Yi ◽  
Zhiqun Xu ◽  
Xiaodong Xie ◽  
...  
Keyword(s):  
Environmental Toxicology ◽  
Oxidative Removal ◽  
Immobilized Beads ◽  
Toxicology Assessment

The role of toxicology assessment in transfusion medicine

Transfusion ◽  
2003 ◽  
Vol 43 (10) ◽  
pp. 1481-1492 ◽  
Author(s):  
Vic Ciaravino ◽  
Tim McCullough ◽  
George Cimino
Keyword(s):  
Transfusion Medicine ◽  
Toxicology Assessment

Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment

2021 ◽  
Author(s):  
Terry Ching ◽  
Yi-Chin Toh ◽  
Michinao Hashimoto ◽  
Yu Shrike Zhang
Keyword(s):  
Organ On A Chip ◽  
Toxicology Assessment

Environmental Metabolomics: A Powerful Tool to Investigate Biochemical Responses to Drugs in Nontarget Organisms

2020 ◽  
pp. 441-465
Author(s):  
Giovanni Mastroianni ◽  
Monica Scognamiglio ◽  
Chiara Russo ◽  
Antonio Fiorentino ◽  
Margherita Lavorgna
Keyword(s):  
Nontarget Organisms ◽  
Biochemical Responses ◽  
Environmental Metabolomics

scholarly journals Stem Cell-Derived Systems in Toxicology Assessment

2015 ◽  
Vol 24 (11) ◽  
pp. 1284-1296 ◽  
Author(s):  
Laura Suter-Dick ◽  
Paula M. Alves ◽  
Bas J. Blaauboer ◽  
Klaus-Dieter Bremm ◽  
Catarina Brito ◽  
...  
Keyword(s):  
Stem Cell ◽  
Toxicology Assessment

Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment

2006 ◽  
Vol 53 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Marshall Leslie Tattersall ◽  
Michael Dymond ◽  
Tim Hammond ◽  
Jean-Pierre Valentin
Keyword(s):  
Heart Rate ◽  
Beagle Dogs ◽  
Toxicology Assessment
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