Ventricular Tachycardia and Fibrillation: Pharmacologic Therapy

Author(s):  
Gerald V. Naccarelli ◽  
John Field
2003 ◽  
Vol 67 (1) ◽  
pp. 93-95 ◽  
Author(s):  
Tsutomu Araki ◽  
Tetsuo Konno ◽  
Hideki Itoh ◽  
Hidekazu Ino ◽  
Masami Shimizu

1989 ◽  
Vol 9 (5) ◽  
pp. 36-40 ◽  
Author(s):  
LL Stevens ◽  
RM Redd ◽  
TA Buckingham

Catheter ablation, in extreme cases, can be used successfully as emergency therapy for VT in the CCU. In the hands of a physician experienced in electrophysiologic procedures, catheter ablation may prove to be an alternative to surgical or pharmacologic therapy in acutely ill patients with refractory ventricular arrhythmias.


1983 ◽  
Vol 245 (1) ◽  
pp. H82-H89 ◽  
Author(s):  
D. E. Euler ◽  
J. F. Spear ◽  
E. N. Moore

The proximal left circumflex coronary artery was occluded for 1 h in 16 open-chest sheep anesthetized with pentobarbital sodium. Epicardial conduction was monitored at three or four sites within the ischemic zone and one site in the normal zone. Eight of the sheep developed ventricular fibrillation within the first 15 min of occlusion; the remaining sheep survived the 1-h observation period. In the sheep that developed spontaneous ventricular fibrillation, the circumflex perfused a significantly greater amount of the left ventricle (44 +/- 3 vs. 39 +/- 3%; P = 0.008). The occurrence of spontaneous ventricular fibrillation was invariably preceded by a period of sustained (0.5-4 min) ventricular tachycardia. Six of the surviving sheep developed episodes of sustained (2-10 min) tachycardia that were self-terminating. The ischemic zone electrograms showed continuous fractionated electrical activity during both self-terminating tachycardias and tachycardias ending in fibrillation. The continuous epicardial electrical activity did not appear to cause the tachycardias but rather occurred as a result of the tachycardias. The genesis of ventricular tachycardia and fibrillation in this model may involve mechanisms different from ischemia-induced ventricular tachycardia and fibrillation in canine and porcine hearts.


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