Supervised Machine Learning Approach for Subjectivity/Objectivity Classification of Social Data

Inspired by natural language processing techniques we here introduce Mol2vec which is an unsupervised machine learning approach to learn vector representations of molecular substructures. Similarly, to the Word2vec models where vectors of closely related words are in close proximity in the vector space, Mol2vec learns vector representations of molecular substructures that are pointing in similar directions for chemically related substructures. Compounds can finally be encoded as vectors by summing up vectors of the individual substructures and, for instance, feed into supervised machine learning approaches to predict compound properties. The underlying substructure vector embeddings are obtained by training an unsupervised machine learning approach on a so-called corpus of compounds that consists of all available chemical matter. The resulting Mol2vec model is pre-trained once, yields dense vector representations and overcomes drawbacks of common compound feature representations such as sparseness and bit collisions. The prediction capabilities are demonstrated on several compound property and bioactivity data sets and compared with results obtained for Morgan fingerprints as reference compound representation. Mol2vec can be easily combined with ProtVec, which employs the same Word2vec concept on protein sequences, resulting in a proteochemometric approach that is alignment independent and can be thus also easily used for proteins with low sequence similarities.

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Coreference resolution of Korean anaphoric zero objects: Towards a supervised machine learning approach

International Journal of Computer Science and Information Technology for Education ◽

10.21742/ijcsite.2016.1.01 ◽

2016 ◽

Vol 1 (1) ◽

pp. 1-6

Author(s):

Euhee Kim ◽

◽

Myung-Kwan Park ◽

Keyword(s):

Machine Learning ◽

Supervised Machine Learning ◽

Learning Approach ◽

Coreference Resolution ◽

Machine Learning Approach

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A Machine Learning Approach to Study Glycosidase Activities from Bifidobacterium

Microorganisms ◽

10.3390/microorganisms9051034 ◽

2021 ◽

Vol 9 (5) ◽

pp. 1034

Author(s):

Carlos Sabater ◽

Lorena Ruiz ◽

Abelardo Margolles

Keyword(s):

Machine Learning ◽

Supervised Classification ◽

Machine Learning Algorithms ◽

Learning Approach ◽

Human Milk Oligosaccharides ◽

Future Studies ◽

High Fiber ◽

Machine Learning Approach ◽

Prebiotic Oligosaccharides

This study aimed to recover metagenome-assembled genomes (MAGs) from human fecal samples to characterize the glycosidase profiles of Bifidobacterium species exposed to different prebiotic oligosaccharides (galacto-oligosaccharides, fructo-oligosaccharides and human milk oligosaccharides, HMOs) as well as high-fiber diets. A total of 1806 MAGs were recovered from 487 infant and adult metagenomes. Unsupervised and supervised classification of glycosidases codified in MAGs using machine-learning algorithms allowed establishing characteristic hydrolytic profiles for B. adolescentis, B. bifidum, B. breve, B. longum and B. pseudocatenulatum, yielding classification rates above 90%. Glycosidase families GH5 44, GH32, and GH110 were characteristic of B. bifidum. The presence or absence of GH1, GH2, GH5 and GH20 was characteristic of B. adolescentis, B. breve and B. pseudocatenulatum, while families GH1 and GH30 were relevant in MAGs from B. longum. These characteristic profiles allowed discriminating bifidobacteria regardless of prebiotic exposure. Correlation analysis of glycosidase activities suggests strong associations between glycosidase families comprising HMOs-degrading enzymes, which are often found in MAGs from the same species. Mathematical models here proposed may contribute to a better understanding of the carbohydrate metabolism of some common bifidobacteria species and could be extrapolated to other microorganisms of interest in future studies.

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