Patient-Reported Outcomes and Quality of Life in Pancreatic Cancer

AbstractObjective:People with pancreatic cancer have poor survival, and management is challenging. Pancreatic cancer patients' perceptions of their care coordination and its association with their outcomes have not been well-studied. Our objective was to determine if perception of care coordination is associated with patient-reported outcomes or survival.Methods:People with pancreatic cancer who were 1–8 months postdiagnosis (52 with completed resection and 58 with no resection) completed a patient-reported questionnaire that assessed their perceptions of care coordination, quality of life, anxiety, and depression using validated instruments. Mean scores for 15 care-coordination items were calculated and then ranked from highest (best experience) to lowest (worst experience). Associations between care-coordination scores (including communication and navigation domains) and patient-reported outcomes and survival were investigated using general linear regression and Cox regression, respectively. All analyses were stratified by whether or not the tumor had been resected.Results:In both groups, the highest-ranked care-coordination items were: knowing who was responsible for coordinating care, health professionals being informed about their history, and waiting times. The worst-ranked items related to: how often patients were asked about visits with other health professionals and how well they and their family were coping, knowing the symptoms they should monitor, having sufficient emotional help from staff, and access to additional specialist services. For people who had a resection, better communication and navigation scores were significantly associated with higher quality of life and less anxiety and depression. However, these associations were not statistically significant for those with no resection. Perception of cancer care coordination was not associated with survival in either group.Significance of results:Our results suggest that, while many core clinical aspects of care are perceived to be done well for pancreatic cancer patients, improvements in emotional support, referral to specialist services, and self-management education may improve patient-reported outcomes.

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Health-related quality of life in gastric cancer: Assessing pooled international data from a patient-reported-outcomes health status questionnaire

PsycEXTRA Dataset ◽

10.1037/e686862011-001 ◽

2011 ◽

Author(s):

Scott M. Debb

Keyword(s):

Quality Of Life ◽

Gastric Cancer ◽

Health Status ◽

Patient Reported Outcomes ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related ◽

International Data

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P048 QUALITY OF LIFE AND OTHER PATIENT REPORTED OUTCOMES IN PATIENTS WITH POUCHITIS

Gastroenterology ◽

10.1053/j.gastro.2019.11.251 ◽

2020 ◽

Vol 158 (3) ◽

pp. S107

Author(s):

Edward Barnes ◽

Millie Long ◽

Laura Raffals ◽

Xian Zhang ◽

Anuj Vyas ◽

...

Keyword(s):

Quality Of Life ◽

Patient Reported Outcomes ◽

Patient Reported

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Quality of life, effectiveness and patient reported outcomes of antiemetic prophylaxis with NEPA within the German NIS AkyPRO: post-hoc analysis of patients receiving carboplatin-based chemotherapy

10.1055/s-0040-1710726 ◽

2020 ◽

Author(s):

J Schilling ◽

R Lorenz ◽

D Rezek ◽

L Bauer ◽

D Hornung ◽

...

Keyword(s):

Quality Of Life ◽

Patient Reported Outcomes ◽

Life Effectiveness ◽

Post Hoc Analysis ◽

Antiemetic Prophylaxis ◽

Patient Reported ◽

Post Hoc

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A three month interim analysis of quality of life in patients with relapsing remitting multiple sclerosis in the UK: the Patient Reported Outcomes with Fingolimod in Local Experience (PROFILE) study

10.26226/morressier.59a3e8b7d462b8028d895a36 ◽

2017 ◽

Author(s):

Michel Kroes

Keyword(s):

Quality Of Life ◽

Interim Analysis ◽

Patient Reported Outcomes ◽

Local Experience ◽

Patient Reported ◽

Relapsing Remitting ◽

The Uk ◽

Relapsing Remitting Multiple Sclerosis ◽

Profile Study

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Understanding quality of life and treatment history of patients with Bertolotti syndrome compared with lumbosacral radiculopathy

Journal of Neurosurgery Spine ◽

10.3171/2019.2.spine1953 ◽

2019 ◽

Vol 31 (2) ◽

pp. 222-228 ◽

Cited By ~ 1

Author(s):

Joshua L. Golubovsky ◽

Arbaz Momin ◽

Nicolas R. Thompson ◽

Michael P. Steinmetz

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Propensity Score ◽

Disc Herniation ◽

Symptom Onset ◽

Patient Reported Outcomes ◽

Lumbosacral Radiculopathy ◽

Patient Reported ◽

Age And Sex

OBJECTIVEBertolotti syndrome is a rare spinal condition that causes low-back pain due to a lumbosacral transitional vertebra (LSTV), which is a pseudoarticulation between the fifth lumbar transverse process and the sacral ala. Bertolotti syndrome patients are rarely studied, particularly with regard to their quality of life. This study aimed to examine the quality of life and prior treatments in patients with Bertolotti syndrome at first presentation to the authors’ center in comparison with those with lumbosacral radiculopathy.METHODSThis study was a retrospective cohort analysis of patients with Bertolotti syndrome and lumbosacral radiculopathy due to disc herniation seen at the authors’ institution’s spine center from 2005 through 2018. Diagnoses were confirmed with provider notes and imaging. Variables collected included demographics, diagnostic history, prior treatment, patient-reported quality of life metrics, and whether or not they underwent surgery at the authors’ institution. Propensity score matching by age and sex was used to match lumbosacral radiculopathy patients to Bertolotti syndrome patients. Group comparisons were made using t-tests, Fisher’s exact test, Mann-Whitney U-tests, Cox proportional hazards models, and linear regression models where variables found to be different at the univariate level were included as covariates.RESULTSThe final cohort included 22 patients with Bertolotti syndrome who had patient-reported outcomes data available and 46 propensity score–matched patients who had confirmed radiculopathy due to disc herniation. The authors found that Bertolotti syndrome patients had significantly more prior epidural steroid injections (ESIs) and a longer time from symptom onset to their first visit. Univariate analysis showed that Bertolotti syndrome patients had significantly worse Patient-Reported Outcomes Measurement Information System (PROMIS) mental health T-scores. Adjustment for prior ESIs and time from symptom onset revealed that Bertolotti syndrome patients also had significantly worse PROMIS physical health T-scores. Time to surgery and other quality of life metrics did not differ between groups.CONCLUSIONSPatients with Bertolotti syndrome undergo significantly longer workup and more ESIs and have worse physical and mental health scores than age- and sex-matched patients with lumbosacral radiculopathy. However, both groups of patients had mild depression and clinically meaningful reduction in their quality of life according to all instruments. This study shows that Bertolotti syndrome patients have a condition that affects them potentially more significantly than those with lumbosacral radiculopathy, and increased attention should be paid to these patients to improve their workup, diagnosis, and treatment.

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