Carbonic anhydrase inhibition in ophthalmology: Aqueous humor secretion and the development of sulfonamide inhibitors

2000 ◽  
pp. 425-435 ◽  
Author(s):  
Thomas H. Maren
Keyword(s):  
Carbonic Anhydrase ◽  
Aqueous Humor ◽  
Carbonic Anhydrase Inhibition

Coumaronochromone as antibacterial and carbonic anhydrase inhibitors from Aerva persica (Burm.f.) Merr.: experimental and first-principles approaches

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Muhammad Imran ◽  
Ahmad Irfan ◽  
Mohammed A. Assiri ◽  
Sajjad H. Sumrra ◽  
Muhammad Saleem ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
First Principles ◽  
Molecular Electrostatic Potential ◽  
Chemical Constituents ◽  
Bacterial Strains ◽  
Hirshfeld Analysis ◽  
Carbonic Anhydrase Inhibition ◽  
Inhibition Studies ◽  
Lowest Unoccupied Molecular Orbitals

AbstractThe Aerva plants are exceptionally rich in phytochemicals and possess therapeutics potential. Phytochemical screening shows that Aerva persica (Burm.f.) Merr. contains highest contents i.e., total phenolics, flavonoids, flavonols, tannins, alkaloids, carbohydrates, anthraquinones and glycosides. In-vitro antibacterial and enzymatic (carbonic anhydrase) inhibition studies on methanol extracts of A. persica indicated the presence of biological active constituents within chloroform soluble portions. Investigation in the pure constituents on the chloroform portions of A. persica accomplished by column chromatography, NMR and MS analysis. The bioguided isolation yields four chemical constituents of coumaronochromone family, namely aervin (1-4). These pure chemical entities (1-4) showed significant antibacterial activity in the range of 60.05–79.21 µg/ml against various bacterial strains using ampicillin and ciprofloxacin as standard drugs. The compounds 1-4 showed promising carbonic anhydrase inhibition with IC50 values of 19.01, 18.24, 18.65 and 12.92 µM, respectively, using standard inhibitor acetazolamide. First-principles calculations revealed comprehensive intramolecular charge transfer in the studied compounds 1-4. The spatial distribution of highest occupied and lowest unoccupied molecular orbitals, ionization potential, molecular electrostatic potential and Hirshfeld analysis revealed that these coumaronochromone compounds would be proficient biological active compounds. These pure constituents may be used as a new pharmacophore to treat leaukomia, epilepsy, glaucoma and cystic fibrosis.

scholarly journals Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models

2021 ◽  
Vol 36 (1) ◽  
pp. 964-976
Author(s):  
Ilaria Dettori ◽  
Irene Fusco ◽  
Irene Bulli ◽  
Lisa Gaviano ◽  
Elisabetta Coppi ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Protective Effects ◽  
Brain Ischaemia ◽  
In Vivo Models ◽  
Carbonic Anhydrase Inhibition

scholarly journals Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?

2021 ◽  
Vol 36 (1) ◽  
pp. 1230-1235
Author(s):  
Secil Deniz ◽  
Tugba Kevser Uysal ◽  
Clemente Capasso ◽  
Claudiu T. Supuran ◽  
Ozen Ozensoy Guler
Keyword(s):  
Carbonic Anhydrase ◽  
Complementary Therapy ◽  
Carbonic Anhydrase Inhibition

scholarly journals Inhibition of Gastric Secretion of Hydrochloric Acid in vivo by Carbonic Anhydrase Inhibition

Nature ◽  
1952 ◽  
Vol 170 (4325) ◽  
pp. 499-499 ◽  
Author(s):  
HENRY D. JANOWITZ ◽  
HENRY COLCHER ◽  
FRANKLIN HOLLANDER
Keyword(s):  
Hydrochloric Acid ◽  
Carbonic Anhydrase ◽  
Gastric Secretion ◽  
Carbonic Anhydrase Inhibition ◽  
Inhibition Of Gastric Secretion

2 H -Thieno[3,2- e ]- and [2,3- e ]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit

2000 ◽  
Vol 8 (5) ◽  
pp. 957-975 ◽  
Author(s):  
Hwang-Hsing Chen ◽  
Sharon Gross ◽  
John Liao ◽  
Marsha McLaughlin ◽  
Tom Dean ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Inhibition
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