Experimental Identification of a System Containing Geometric Nonlinearities

Author(s):  
Julian M. Londono ◽  
Jonathan E. Cooper
Author(s):  
Haiyuan Liu ◽  
Xin Huo ◽  
Zhaosheng Guo ◽  
Sizhao Feng ◽  
Yongjiang Pi ◽  
...  

2019 ◽  
Vol 14 (3) ◽  
pp. 211-225 ◽  
Author(s):  
Ming Fang ◽  
Xiujuan Lei ◽  
Ling Guo

Background: Essential proteins play important roles in the survival or reproduction of an organism and support the stability of the system. Essential proteins are the minimum set of proteins absolutely required to maintain a living cell. The identification of essential proteins is a very important topic not only for a better comprehension of the minimal requirements for cellular life, but also for a more efficient discovery of the human disease genes and drug targets. Traditionally, as the experimental identification of essential proteins is complex, it usually requires great time and expense. With the cumulation of high-throughput experimental data, many computational methods that make useful complements to experimental methods have been proposed to identify essential proteins. In addition, the ability to rapidly and precisely identify essential proteins is of great significance for discovering disease genes and drug design, and has great potential for applications in basic and synthetic biology research. Objective: The aim of this paper is to provide a review on the identification of essential proteins and genes focusing on the current developments of different types of computational methods, point out some progress and limitations of existing methods, and the challenges and directions for further research are discussed.


Author(s):  
Luiz Antonio Farani de Souza ◽  
Douglas Fernandes dos Santos ◽  
Rodrigo Yukio Mizote Kawamoto ◽  
Leandro Vanalli

This paper presents a new algorithm to solve the system of nonlinear equations that describes the static equilibrium of trusses with material and geometric nonlinearities, adapting a three-step method with fourth-order convergence found in the literature. The co-rotational formulation of the Finite Element Method is used in the discretization of structures. The nonlinear behavior of the material is characterized by an elastoplastic constitutive model. The equilibrium paths with limit points of load and displacement are obtained using the linearized Arc-Length path-following technique. The numerical results obtained with the free program Scilab show that the new algorithm converges faster than standard procedures and modified Newton-Raphson, since the approximate solution of the problem is obtained with a smaller number of accumulated iterations and less CPU time. The equilibrium paths show that the structures exhibit a completely different behavior when the material nonlinearity is considered in the analysis with large displacements.


2011 ◽  
Author(s):  
Liviu Bereteu ◽  
Gheorghe Eugen Drăgănescu ◽  
Dan Viorel Stănescu ◽  
Madalin Bunoiu ◽  
Iosif Malaescu

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