Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis

2015 ◽  
pp. 155-174
Author(s):  
Lu Deng ◽  
Jiahui Xu ◽  
Dong Wang ◽  
Suling Liu
Keyword(s):  
Stem Cells ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Mammary Stem

Abstract B19: MYC induces PLD6 to suppress YAP/TAZ-dependent self-renewal of mammary stem cells

2015 ◽  
Author(s):  
Bjoern von Eyss ◽  
Laura Annika Jaenicke ◽  
Katrin Wiese ◽  
Andreas Rosenwald ◽  
Martin Eilers
Keyword(s):  
Stem Cells ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Mammary Stem

scholarly journals Mammary stem cells, self-renewal pathways, and carcinogenesis

2005 ◽  
Vol 7 (3) ◽  
Author(s):  
Suling Liu ◽  
Gabriela Dontu ◽  
Max S Wicha
Keyword(s):  
Stem Cells ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Mammary Stem

scholarly journals Wnts as Self-Renewal Factors: Mammary Stem Cells and Beyond

2010 ◽  
Vol 6 (6) ◽  
pp. 494-495
Author(s):  
Esther M. Verheyen ◽  
Hans Clevers
Keyword(s):  
Stem Cells ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Mammary Stem

scholarly journals Hedgehog Signaling and Bmi-1 Regulate Self-renewal of Normal and Malignant Human Mammary Stem Cells

2006 ◽  
Vol 66 (12) ◽  
pp. 6063-6071 ◽  
Author(s):  
Suling Liu ◽  
Gabriela Dontu ◽  
Ilia D. Mantle ◽  
Shivani Patel ◽  
Nam-shik Ahn ◽  
...  
Keyword(s):  
Stem Cells ◽  
Hedgehog Signaling ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Mammary Stem

scholarly journals Asymmetric cell division of mammary stem cells

Cell Division ◽  
2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Shaan N. Chhabra ◽  
Brian W. Booth
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Division ◽  
Asymmetric Cell Division ◽  
Mammary Stem Cells ◽  
Self Renewal ◽  
Symmetric Division ◽  
Daughter Cells ◽  
Mammary Stem

AbstractSomatic stem cells are distinguished by their capacity to regenerate themselves and also to produce daughter cells that will differentiate. Self-renewal is achieved through the process of asymmetric cell division which helps to sustain tissue morphogenesis as well as maintain homeostasis. Asymmetric cell division results in the development of two daughter cells with different fates after a single mitosis. Only one daughter cell maintains “stemness” while the other differentiates and achieves a non-stem cell fate. Stem cells also have the capacity to undergo symmetric division of cells that results in the development of two daughter cells which are identical. Symmetric division results in the expansion of the stem cell population. Imbalances and deregulations in these processes can result in diseases such as cancer. Adult mammary stem cells (MaSCs) are a group of cells that play a critical role in the expansion of the mammary gland during puberty and any subsequent pregnancies. Furthermore, given the relatively long lifespans and their capability to undergo self-renewal, adult stem cells have been suggested as ideal candidates for transformation events that lead to the development of cancer. With the possibility that MaSCs can act as the source cells for distinct breast cancer types; understanding their regulation is an important field of research. In this review, we discuss asymmetric cell division in breast/mammary stem cells and implications on further research. We focus on the background history of asymmetric cell division, asymmetric cell division monitoring techniques, identified molecular mechanisms of asymmetric stem cell division, and the role asymmetric cell division may play in breast cancer.

scholarly journals Mammary Stem Cells: Premise, Properties, and Perspectives

2017 ◽  
Vol 27 (8) ◽  
pp. 556-567 ◽  
Author(s):  
Bethan Lloyd-Lewis ◽  
Olivia B. Harris ◽  
Christine J. Watson ◽  
Felicity M. Davis
Keyword(s):  
Stem Cells ◽  
Mammary Stem Cells ◽  
Mammary Stem
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