Monitoring Cerebral Autoregulation After Subarachnoid Hemorrhage

2016 ◽  
pp. 199-203 ◽  
Author(s):  
Karol P. Budohoski ◽  
Marek Czosnyka ◽  
Peter Smielewski ◽  
Georgios V. Varsos ◽  
Magdalena Kasprowicz ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Autoregulation

Treatment of Subarachnoid Hemorrhage with Sodium Nitroprusside and Phenylephrine

Neurosurgery ◽  
1979 ◽  
Vol 5 (5) ◽  
pp. 588-595 ◽  
Author(s):  
Charles S. Rothberg ◽  
Bryce Weir ◽  
Thomas R. Overton
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Sodium Nitroprusside ◽  
Cerebral Vasospasm ◽  
Cerebral Autoregulation ◽  
Regional Cerebral Blood Flow ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Poor Survival ◽  
Cerebrovascular Resistance ◽  
Intravenous Sodium

Abstract The effectiveness of simultaneous intravenous sodium nitroprusside and phenylephrine in improving the cerebrovascular disturbances and survival rate after induced subarachnoid hemorrhage (SAH) was studied in the cynomolgus monkey. We measured regional cerebral blood flow (rCBF) using the intra-arterial xenon-133 clearance technique. In our experimental animal model, SAH was associated with a persistent reduction in rCBF, elevation of cerebrovascular resistance (CVR), cerebral vasospasm for the duration of the study (150 minutes), and poor survival. For animals receiving the treatment regime (administered approximately 25 minutes after the induced SAH), rCBF remained low, CVR was high, and cerebral vasospasm was persistent. Survival in this group was the same as that observed for the untreated animals. Simultaneous administration of sodium nitroprusside and phenylephrine was ineffective in improving rCBF, CVR, cerebral vasospasm. or survival after SAH. In the control group (receiving only the treatment and not an intracranial insult), rCBF was below resting levels both during and after therapy, indicating impaired cerebral autoregulation.

Changes on Dynamic Cerebral Autoregulation Are Associated with Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage (P06.257)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P06.257-P06.257
Author(s):  
S. Ortega-Gutierrez ◽  
N. Petersen ◽  
A. Reccius ◽  
A. Huang ◽  
G. Linares-Tapia ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Ischemia ◽  
Cerebral Autoregulation ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Delayed Cerebral Ischemia ◽  
Dynamic Cerebral Autoregulation

scholarly journals Impairment of Cerebral Autoregulation Predicts Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Stroke ◽  
2012 ◽  
Vol 43 (12) ◽  
pp. 3230-3237 ◽  
Author(s):  
Karol P. Budohoski ◽  
Marek Czosnyka ◽  
Peter Smielewski ◽  
Magdalena Kasprowicz ◽  
Adel Helmy ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Ischemia ◽  
Cerebral Autoregulation ◽  
Delayed Cerebral Ischemia

Continuous Assessment of Cerebral Autoregulation in Subarachnoid Hemorrhage

2004 ◽  
pp. 1133-1139 ◽  
Author(s):  
Martin Soehle ◽  
Marek Czosnyka ◽  
John D. Pickard ◽  
Peter J. Kirkpatrick
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Autoregulation ◽  
Continuous Assessment

Transcranial Doppler ultrasound studies of cerebral autoregulation and subarachnoid hemorrhage in the rabbit

1990 ◽  
Vol 73 (4) ◽  
pp. 601-610 ◽  
Author(s):  
Richard J. Nelson ◽  
Sheila Perry ◽  
Tony K. Hames ◽  
John D. Pickard
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Flow Velocity ◽  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Cerebral Autoregulation ◽  
Time Course ◽  
Cerebrovascular Reactivity ◽  
Waveform Analysis ◽  
Content Type ◽  
Fine Print

✓ The authors describe a method for Doppler ultrasound recording of flow velocity in the basilar artery of normal rabbits and rabbits with experimental subarachnoid hemorrhage (SAH). With this transcranial Doppler (TCD) model, clinical assumptions regarding flow velocity/cerebral blood flow (CBF) relationships, autoregulatory responses, and Doppler spectral waveform analysis can be tested under controlled conditions and compared with established methods of CBF measurement (hydrogen clearance). The time course of changes in flow velocity following SAH (cerebral vasospasm) is successfully demonstrated using the experimental TCD method. There are significant differences in the flow velocity and CBF responses to hypercapnia, hypocapnia, and trimethaphan-induced hypotension which indicate that TCD cannot be considered a simple alternative to CBF measurement for the study of cerebrovascular reactivity and cerebral autoregulation.

Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Using Cerebral Blood Flow Velocities and Cerebral Autoregulation Assessment

2015 ◽  
Vol 23 (2) ◽  
pp. 253-258 ◽  
Author(s):  
Lionel Calviere ◽  
Nathalie Nasr ◽  
Catherine Arnaud ◽  
Marek Czosnyka ◽  
Alain Viguier ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Ischemia ◽  
Cerebral Autoregulation ◽  
Delayed Cerebral Ischemia ◽  
Blood Flow Velocities ◽  
Flow Velocities

The Role of Monitoring Cerebral Autoregulation After Subarachnoid Hemorrhage

Neurosurgery ◽  
2015 ◽  
Vol 62 (CN_suppl_1) ◽  
pp. 180-184 ◽  
Author(s):  
Karol P. Budohoski ◽  
Marek Czosnyka ◽  
Peter J. Kirkpatrick
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cerebral Autoregulation
Sign in / Sign up

Export Citation Format

Share Document