scholarly journals Spatial Distribution of Changes in Oxidised Cytochrome C Oxidase During Visual Stimulation Using Broadband Near Infrared Spectroscopy Imaging

Author(s):  
P. Phan ◽  
D. Highton ◽  
S. Brigadoi ◽  
I. Tachtsidis ◽  
M. Smith ◽  
...  
NeuroImage ◽  
2004 ◽  
Vol 22 (1) ◽  
pp. 109-119 ◽  
Author(s):  
Kâmil Uludağ ◽  
Jens Steinbrink ◽  
Matthias Kohl-Bareis ◽  
Rüdiger Wenzel ◽  
Arno Villringer ◽  
...  

2017 ◽  
Vol 4 (2) ◽  
pp. 021105 ◽  
Author(s):  
Sabrina Brigadoi ◽  
Phong Phan ◽  
David Highton ◽  
Samuel Powell ◽  
Robert J. Cooper ◽  
...  

2017 ◽  
Vol 37 (12) ◽  
pp. 3789-3802 ◽  
Author(s):  
Xinlong Wang ◽  
Fenghua Tian ◽  
Divya D Reddy ◽  
Sahil S Nalawade ◽  
Douglas W Barrett ◽  
...  

Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS. Placebo experiments were also performed for accurate comparison. Time course of spectroscopic readings were analyzed and fitted to the modified Beer–Lambert law. With respect to the placebo readings, we observed (1) significant increases in cerebral concentrations of oxidized CCO (Δ[CCO]; >0.08 µM; p < 0.01), oxygenated hemoglobin (Δ[HbO]; >0.8 µM; p < 0.01), and total hemoglobin (Δ[HbT]; >0.5 µM; p < 0.01) during and after TILS, and (2) linear interplays between Δ[CCO] versus Δ[HbO] and between Δ[CCO] versus Δ[HbT]. Ratios of Δ[CCO]/Δ[HbO] and Δ[CCO]/Δ[HbT] were introduced as TILS-induced metabolic-hemodynamic coupling indices to quantify the coupling strength between TILS-enhanced cerebral metabolism and blood oxygen supply. This study provides the first demonstration that TILS causes up-regulation of oxidized CCO in the human brain, and contributes important insight into the physiological mechanisms.


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