Fast Similarity Search in Scalar Fields using Merging Histograms

2017 ◽  
pp. 121-134
Author(s):  
Himangshu Saikia ◽  
Hans-Peter Seidel ◽  
Tino Weinkauf
Keyword(s):  
Similarity Search ◽  
Scalar Fields

Similarity Search in Data Stream with Adaptive Segmental Approximations

2009 ◽  
Vol 20 (10) ◽  
pp. 2867-2884 ◽  
Author(s):  
Feng WU ◽  
Yan ZHONG ◽  
Quan-Yuan WU ◽  
Yan JIA ◽  
Shu-Qiang YANG
Keyword(s):  
Similarity Search ◽  
Data Stream

PPR based similarity search for gas monitoring data

2009 ◽  
Vol 28 (10) ◽  
pp. 2721-2721 ◽  
Author(s):  
Ai-guo LI ◽  
Hua ZHAO
Keyword(s):  
Similarity Search ◽  
Monitoring Data ◽  
Gas Monitoring

Combined QSAR Model and Chemical Similarity Search for Novel HMG-CoA Reductase Inhibitors for Coronary Heart Disease

2020 ◽  
Vol 16 (4) ◽  
pp. 473-485
Author(s):  
David Mary Rajathei ◽  
Subbiah Parthasarathy ◽  
Samuel Selvaraj
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Similarity Search ◽  
Qsar Model ◽  
Chemical Similarity ◽  
Cholesterol Accumulation ◽  
Reductase Inhibitors ◽  
Pubchem Database ◽  
Hmg Coa Reductase Inhibitors ◽  
Coa Reductase

Background: Coronary heart disease generally occurs due to cholesterol accumulation in the walls of the heart arteries. Statins are the most widely used drugs which work by inhibiting the active site of 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) enzyme that is responsible for cholesterol synthesis. A series of atorvastatin analogs with HMGCR inhibition activity have been synthesized experimentally which would be expensive and time-consuming. Methods: In the present study, we employed both the QSAR model and chemical similarity search for identifying novel HMGCR inhibitors for heart-related diseases. To implement this, a 2D QSAR model was developed by correlating the structural properties to their biological activity of a series of atorvastatin analogs reported as HMGCR inhibitors. Then, the chemical similarity search of atorvastatin analogs was performed by using PubChem database search. Results and Discussion: The three-descriptor model of charge (GATS1p), connectivity (SCH-7) and distance (VE1_D) of the molecules is obtained for HMGCR inhibition with the statistical values of R2= 0.67, RMSEtr= 0.33, R2 ext= 0.64 and CCCext= 0.76. The 109 novel compounds were obtained by chemical similarity search and the inhibition activities of the compounds were predicted using QSAR model, which were close in the range of experimentally observed threshold. Conclusion: The present study suggests that the QSAR model and chemical similarity search could be used in combination for identification of novel compounds with activity by in silico with less computation and effort.

scholarly journals New AdS4 vacua in dyonic ISO(7) gauged supergravity

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Nikolay Bobev ◽  
Thomas Fischbacher ◽  
Fridrik Freyr Gautason ◽  
Krzysztof Pilch
Keyword(s):  
Scalar Fields ◽  
Global Symmetry ◽  
Supergravity Theory

Abstract We identify 219 AdS4 solutions in four-dimensional dyonically gauged ISO(7) $$ \mathcal{N} $$ N = 8 supergravity and present some of their properties. One of the new solutions preserves $$ \mathcal{N} $$ N = 1 supersymmetry and provides a rare explicit example of an AdS4 vacuum dual to a 3d SCFT with no continuous global symmetry. There are also two new non-supersymmetric solutions for which all 70 scalar fields in the supergravity theory have masses above the BF bound. All of these AdS4 solutions can be uplifted to massive type IIA supergravity. Motivated by this we present the low lying operator spectra of the dual 3d CFTs for all known supersymmetric AdS4 solutions in the theory and organize them into superconformal multiplets.

scholarly journals Efficient EMD-based Similarity Search via Batch Pruning and Incremental Computation

2021 ◽  
pp. 1-1
Author(s):  
Yu Chen ◽  
Yong Zhang ◽  
Jin Wang ◽  
Jiacheng Wu ◽  
Chunxiao Xing
Keyword(s):  
Similarity Search ◽  
Incremental Computation

scholarly journals Symmetry and unification from soft theorems and unitarity

2021 ◽  
Vol 2021 (5) ◽  
Author(s):  
Clifford Cheung ◽  
Zander Moss
Keyword(s):  
Symmetry Algebra ◽  
Scalar Fields ◽  
Particle Interactions ◽  
Massive Scalar ◽  
Coset Space ◽  
Dimensional Theory ◽  
Finite Spectrum ◽  
Physical Constraints ◽  
High Energies ◽  
Zero Condition

Abstract We argue that symmetry and unification can emerge as byproducts of certain physical constraints on dynamical scattering. To accomplish this we parameterize a general Lorentz invariant, four-dimensional theory of massless and massive scalar fields coupled via arbitrary local interactions. Assuming perturbative unitarity and an Adler zero condition, we prove that any finite spectrum of massless and massive modes will necessarily unify at high energies into multiplets of a linearized symmetry. Certain generators of the symmetry algebra can be derived explicitly in terms of the spectrum and three-particle interactions. Furthermore, our assumptions imply that the coset space is symmetric.

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