Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy

2017 ◽  
pp. 401-421 ◽  
Author(s):  
Subhas Mukherjee ◽  
Daniel J. Brat
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Stem Cell Division

scholarly journals Regulating the balance between symmetric and asymmetric stem cell division in the developing brain

Fly ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 237-241 ◽  
Author(s):  
Boris Egger ◽  
Katrina S. Gold ◽  
Andrea H. Brand
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Developing Brain ◽  
Stem Cell Division

scholarly journals Multilayered gene control drives timely exit from the stem cell state in uncommitted progenitors during Drosophila asymmetric neural stem cell division

2018 ◽  
Vol 32 (23-24) ◽  
pp. 1550-1561 ◽  
Author(s):  
Hideyuki Komori ◽  
Krista L. Golden ◽  
Taeko Kobayashi ◽  
Ryoichiro Kageyama ◽  
Cheng-Yu Lee
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Neural Stem Cell ◽  
Gene Control ◽  
Cell State ◽  
Stem Cell Division ◽  
Stem Cell State

scholarly journals Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Cuie Chen ◽  
Mayu Inaba ◽  
Zsolt G Venkei ◽  
Yukiko M Yamashita
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Cell Fate ◽  
Germline Stem Cell ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Mother And Daughter ◽  
Stem Cell Divisions ◽  
Stem Cell Division ◽  
Male Germline Stem Cells

Asymmetric stem cell division is often accompanied by stereotypical inheritance of the mother and daughter centrosomes. However, it remains unknown whether and how stem cell centrosomes are uniquely regulated and how this regulation may contribute to stem cell fate. Here we identify Klp10A, a microtubule-depolymerizing kinesin of the kinesin-13 family, as the first protein enriched in the stem cell centrosome in Drosophila male germline stem cells (GSCs). Depletion of klp10A results in abnormal elongation of the mother centrosomes in GSCs, suggesting the existence of a stem cell-specific centrosome regulation program. Concomitant with mother centrosome elongation, GSCs form asymmetric spindle, wherein the elongated mother centrosome organizes considerably larger half spindle than the other. This leads to asymmetric cell size, yielding a smaller differentiating daughter cell. We propose that klp10A functions to counteract undesirable asymmetries that may result as a by-product of achieving asymmetries essential for successful stem cell divisions.

scholarly journals DrosophilaSulf1 is required for the termination of intestinal stem cell division during regeneration

Development ◽  
2017 ◽  
Vol 144 (3) ◽  
pp. e1.1-e1.1
Author(s):  
Masahiko Takemura ◽  
Hiroshi Nakato
Keyword(s):  
Stem Cell ◽  
Cell Division ◽  
Intestinal Stem Cell ◽  
Stem Cell Division
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