Simultaneous Cell Detection and Classification with an Asymmetric Deep Autoencoder in Bone Marrow Histology Images

2017 ◽  
pp. 829-838 ◽  
Author(s):  
Tzu-Hsi Song ◽  
Victor Sanchez ◽  
Hesham EIDaly ◽  
Nasir Rajpoot
Keyword(s):  
Bone Marrow ◽  
Cell Detection ◽  
Bone Marrow Histology

scholarly journals Simultaneous Cell Detection and Classification in Bone Marrow Histology Images

2019 ◽  
Vol 23 (4) ◽  
pp. 1469-1476 ◽  
Author(s):  
Tzu-Hsi Song ◽  
Victor Sanchez ◽  
Hesham EI Daly ◽  
Nasir M. Rajpoot
Keyword(s):  
Bone Marrow ◽  
Cell Detection ◽  
Bone Marrow Histology

scholarly journals Reticulin Accumulation in Essential Thrombocythemia: Prognostic Significance and Relationship to Therapy

2009 ◽  
Vol 27 (18) ◽  
pp. 2991-2999 ◽  
Author(s):  
Peter J. Campbell ◽  
David Bareford ◽  
Wendy N. Erber ◽  
Bridget S. Wilkins ◽  
Penny Wright ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Essential Thrombocythemia ◽  
Arterial Thrombosis ◽  
Interobserver Reliability ◽  
Prognostic Significance ◽  
Underlying Disease ◽  
Major Hemorrhage ◽  
Independent Prognostic Marker ◽  
Bone Marrow Histology ◽  
Duration Of Disease

PurposeEssential thrombocythemia (ET) manifests substantial interpatient heterogeneity in rates of thrombosis, hemorrhage, and disease transformation. Bone marrow histology reflects underlying disease activity in ET but many morphological features show poor reproducibility.Patients and MethodsWe evaluated the clinical significance of bone marrow reticulin, a measure previously shown to have relatively high interobserver reliability, in a large, prospectively-studied cohort of ET patients.ResultsReticulin grade positively correlated with white blood cell (P = .05) and platelet counts (P = .0001) at diagnosis. Elevated reticulin levels at presentation predicted higher rates of arterial thrombosis (hazard ratio [HR], 1.8; 95% CI, 1.1 to 2.9; P = .01), major hemorrhage (HR, 2.0; 95% CI, 1.0 to 3.9; P = .05), and myelofibrotic transformation (HR, 5.5; 95% CI, 1.7 to 18.4; P = .0007) independently of known risk factors. Higher reticulin levels at diagnosis were associated with greater subsequent falls in hemoglobin levels in patients treated with anagrelide (P < .0001), but not in those receiving hydroxyurea (P = .9). Moreover, serial trephine specimens in patients randomly assigned to anagrelide showed significantly greater increases in reticulin grade compared with those allocated to hydroxyurea (P = .0003), and four patients who developed increased bone marrow reticulin on anagrelide showed regression of fibrosis when switched to hydroxyurea. These data suggest that patients receiving anagrelide therapy should undergo surveillance bone marrow biopsy every 2 to 3 years and that those who show substantially increasing reticulin levels are at risk of myelofibrotic transformation and may benefit from changing therapy before adverse clinical features develop.ConclusionOur results demonstrate that bone marrow reticulin grade at diagnosis represents an independent prognostic marker in ET, reflecting activity and/or duration of disease, with implications for the monitoring of patients receiving anagrelide.

scholarly journals Osteoarthritic subchondral bone marrow histology. Lessons from changes in alkaptonuria

2019 ◽  
Vol 27 ◽  
pp. S171-S172
Author(s):  
A. Boyde ◽  
L.A. Ranganath ◽  
J.A. Gallagher
Keyword(s):  
Bone Marrow ◽  
Subchondral Bone ◽  
Bone Marrow Histology

Bone marrow histology in myeloma: its importance in diagnosis, prognosis, classification and staging

1982 ◽  
Vol 51 (3) ◽  
pp. 361-375 ◽  
Author(s):  
R. Bartl ◽  
B. Frisch ◽  
R. Burkhardt ◽  
A. Fateh- Moghadam ◽  
G. Mahl ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Histology

Role of PDGF/PDGFR in Regulation of Thrombopoiesis: A Possible Explanation for Imatinib Mesylate-Induced Thrombocytopenia in the Treatment of CML

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3348-3348
Author(s):  
Mo Yang ◽  
Fanyi Meng ◽  
Jie yu Ye ◽  
Yue Xu ◽  
Bin Xiao ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Imatinib Mesylate ◽  
Conflicts Of Interest ◽  
Ex Vivo ◽  
Potential Effect ◽  
Mice Model ◽  
Hematopoietic Stem ◽  
Platelet Recovery ◽  
Bone Marrow Histology

Abstract Abstract 3348 Platelet-derived growth factor (PDGF), a platelet alpha-granule molecule, imply their potential effect in the regulation of megakaryocytopoiesis and thrombopoiesis, which also intimates the existence of an autocrine and/or paracrine loop constructed by megakaryocytes/platelets and their granular constituents. Our previous studies demonstrated the presence of functional PDGF receptors (PDGFR) on human megakaryocytes and platelets (Yang et al, Thromb Haemastasis, 1997) and CD34+ cells, and their ability to mediate a mitogenic response. PDGF promoted the ex vivo expansion of human hematopoietic stem (CD34+) and progenitor (CD41+ CD61+) cells. More significantly, PDGF enhanced the engraftment of human CD45+ cells and their myeloid subsets (CD33+, CD14+ cells) in NOD/SCID mice. PDGF stimulated in vitro megakaryocytopoiesis via PDGFR and/or the indirect effect on bone marrow microenvironment to produce TPO and other cytokines. It also showed a direct stimulatory effect of PDGF on c-Fos, GATA-1 and NF-E2 expressions in megakaryocytes. We speculate that these transcription factors might be involved in the signal transduction of PDGF on the regulation of megakaryocytopoiesis. PDGF also enhanced platelet recovery in mice model with radiation-induced thrombocytopenia. Studies showed that PDGF, like thrombopoietin (TPO), significantly promoted platelet recovery and the formation of bone marrow colony-forming unit-megakaryocyte (CFU-MK) in this irradiated-mouse. An increased number of hematopoietic stem/progenitor cells and a reduction of apoptosis were found in the bone marrow histology sections. In the M-07e apoptotic model, PDGF had a similar anti-apoptotic effect as TPO on megakaryocytes. We also demonstrated that PDGF activated the PI3k/Akt signaling pathway, while addition of imatinib mesylate reduced p-Akt expression. Our findings suggested that the PDGF-initiated radioprotective effect is likely to be mediated via PDGF receptors with subsequent activation of the PI3k/Akt pathway. The study provides a possible explanation that blockage of PDGFR may reduce thrombopoiesis and play a role in imatinib mesylate-induced thrombocytopenia in the treatment of CML. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Bone Marrow Histology in Monoclonal B-Cell Lymphocytosis Shows Various B-Cell Infiltration Patterns

2013 ◽  
Vol 139 (3) ◽  
pp. 390-395 ◽  
Author(s):  
Ulla Randen ◽  
Anne M. Tierens ◽  
Geir E. Tjønnfjord ◽  
Jan Delabie
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Infiltration ◽  
Bone Marrow Histology
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