Atypical Ductal Hyperplasia

2019 ◽  
pp. 33-42
Author(s):  
Werner Boecker
Keyword(s):  
Atypical Ductal Hyperplasia ◽  
Ductal Hyperplasia

Radiologic and Pathologic Features Associated With Upgrade of Atypical Ductal Hyperplasia at Surgical Excision

2019 ◽  
Vol 26 (7) ◽  
pp. 893-899 ◽  
Author(s):  
Kristin E. Williams ◽  
Amanda Amin ◽  
Jacqueline Hill ◽  
Carissa Walter ◽  
Marc Inciardi ◽  
...  
Keyword(s):  
Atypical Ductal Hyperplasia ◽  
Surgical Excision ◽  
Pathologic Features ◽  
Ductal Hyperplasia

The effects of cancer-associated fibroblasts obtained from atypical ductal hyperplasia on anti-tumor immune responses

2018 ◽  
Vol 24 (6) ◽  
pp. 1099-1101
Author(s):  
Betul Gok Yavuz ◽  
Gurcan Gunaydin ◽  
Kemal Kosemehmetoglu ◽  
Derya Karakoc ◽  
Figen Ozgur ◽  
...  
Keyword(s):  
Immune Responses ◽  
Atypical Ductal Hyperplasia ◽  
Cancer Associated Fibroblasts ◽  
Ductal Hyperplasia

Atypical Ductal Hyperplasia: Improved Accuracy with the 11-Gauge Vacuum-Assisted versus the 14-Gauge Core Biopsy Needle

2007 ◽  
Vol 14 (9) ◽  
pp. 2497-2501 ◽  
Author(s):  
Vance Sohn ◽  
Zachary Arthurs ◽  
Garth Herbert ◽  
Joren Keylock ◽  
Jason Perry ◽  
...  
Keyword(s):  
Core Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Biopsy Needle ◽  
Ductal Hyperplasia ◽  
Improved Accuracy

scholarly journals Atypical Ductal Lesions of the Breast: Criteria, Significance, and Laboratory Updates

2018 ◽  
Vol 142 (10) ◽  
pp. 1182-1185 ◽  
Author(s):  
Ellen G. East ◽  
Cody S. Carter ◽  
Celina G. Kleer
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Significance ◽  
Atypical Ductal Hyperplasia ◽  
Data Sources ◽  
Molecular Signature ◽  
Breast Lesions ◽  
Architectural Features ◽  
Increased Risk ◽  
Ductal Hyperplasia ◽  
Benign Breast Lesions

Context.— Atypical ductal hyperplasia (ADH) is a challenging diagnosis defined by cytologic and architectural features that carries an increased risk of subsequent carcinoma when diagnosed in isolation. In addition, ADH may secondarily involve benign breast lesions, wherein it carries variable clinical significance. Objectives.— To review the diagnostic criteria and clinical significance of ADH in isolation and as it involves benign breast lesions, and to review the evolving literature on its molecular signature. Data Sources.— Recently published studies that collectively examine ADH were reviewed. Conclusions.— Atypical ductal hyperplasia carries an increased risk of subsequent carcinoma in isolation and when it involves most benign breast lesions. Identifying which cases of ADH will be upgraded to carcinoma has been challenging, and new laboratory developments, such as EZH2 overexpression, may have a future role.

scholarly journals Atypical Ductal Hyperplasia: Risk Factors for Predicting Pathologic Upgrade on Excisional Biopsy

2021 ◽  
Vol 82 ◽  
Author(s):  
Ko Woon Park ◽  
Boo-Kyung Han ◽  
Sun Jung Rhee ◽  
Soo Youn Cho ◽  
Eun Young Ko ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atypical Ductal Hyperplasia ◽  
Excisional Biopsy ◽  
Ductal Hyperplasia

Minimal (≤0.1 cm) Invasive Carcinoma in Breast Core Needle Biopsies

2004 ◽  
Vol 128 (9) ◽  
pp. 996-999
Author(s):  
Andrew A. Renshaw
Keyword(s):  
Minimally Invasive ◽  
Carcinoma In Situ ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Atypical Ductal Hyperplasia ◽  
Core Needle ◽  
Ductal Hyperplasia ◽  
Ductal Carcinomas ◽  
Invasive Carcinomas

Abstract Context.—Although minimally invasive (microinvasive) carcinoma (≤0.1 cm) of the breast is a well-known and well-characterized entity in excision specimens, the significance of small foci of invasion in breast core needle biopsies has not been well described. Objective.—To define the significance of minimally invasive carcinoma in breast core needle biopsies. Design.—Review of a large series of core needle biopsies for invasive carcinomas measuring 0.1 cm or less and correlation of the results with those of subsequent excision. Setting.—Large community hospital. Results.—From approximately 8500 biopsies, a total of 18 cases of minimally invasive carcinoma from 16 women aged 42 to 80 years were identified. All were present on only 1 of 8 slides made from the block. Overall, the incidence was approximately 0.1% of all biopsies and 1% of all invasive carcinomas. Six cases were invasive lobular carcinomas, 1 was tubulolobular carcinoma, 3 were tubular carcinomas, and the remaining 8 were ductal carcinomas. Eight cases were associated with high-grade comedo ductal carcinomas, 2 with low-grade ductal carcinoma in situ, 3 with atypical ductal hyperplasia, 3 with atypical ductal hyperplasia and lobular carcinoma in situ, and 2 with no other lesion. From a total of 8 sections done entirely through the block, the lesion was present on the first level in 4 cases and the fifth level in 5 cases. No cases were identified in the last 3 levels. Subsequent pathology was available for 16 of the 18 cases. Invasive carcinomas measuring more than 1 cm were present in 9 cases (64%; along with 2 positive lymph nodes), invasive carcinomas less than 1 cm in 2 cases (14%), ductal carcinoma alone in 4 cases (29%), and no carcinoma in 1 case (7%). No pathologic or radiologic features were associated with the finding of invasive carcinoma at excision. Conclusion.—Invasive carcinoma measuring 0.1 cm or less is a rare finding in breast core needle biopsies, is commonly associated with in situ carcinomas and atypical hyperplasias, and is often associated with larger invasive foci at excision. However, invasive carcinomas smaller than 0.1 cm can occur without any other significant findings and may require relatively extensive sampling to identify.

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