Definitions of Substance Dependence

2017 ◽  
pp. 17-24
Author(s):  
H. Thomas Milhorn
Keyword(s):  
1998 ◽  
Author(s):  
M. Kidorf ◽  
◽  
R. K. Brooner ◽  
V. L. King ◽  
K. B. Stoller ◽  
...  
Keyword(s):  

2000 ◽  
Author(s):  
Gloria M. Miele ◽  
Kenneth M. Carpenter ◽  
Melissa Smith Cockerham ◽  
Kristin Dietz Trautman ◽  
Jack Blaine ◽  
...  

Author(s):  
Paul E. Bebbington ◽  
Sally McManus ◽  
Jeremy W. Coid ◽  
Richard Garside ◽  
Terry Brugha

Abstract Purpose Prisoners experience extremely high rates of psychiatric disturbance. However, ex-prisoners have never previously been identified in representative population surveys to establish how far this excess persists after release. Our purpose was to provide the first community-based estimate of ex-prisoners’ mental health in England using the data from the 2014 Adult Psychiatric Morbidity Survey (APMS). Methods APMS 2014 provides cross-sectional data from a random sample (N = 7546) of England’s household population aged 16 or above. Standardised instruments categorised psychiatric disorders and social circumstances. Participants who had been in prison were compared with the rest of the sample. Results One participant in seventy had been in prison (1.4%; 95% CI 1.1–1.7; n = 103). Ex-prisoners suffered an excess of current psychiatric problems, including common mental disorders (CMDs), psychosis, post-traumatic disorder, substance dependence, and suicide attempts. They were more likely to screen positive for attention-deficit/hyperactivity disorder and autistic traits, to have low verbal IQ, and to lack qualifications. They disclosed higher rates of childhood adversity, including physical and sexual abuse and local authority care. The odds (1.88; 95% CI 1.02–3.47) of CMDs were nearly doubled in ex-prisoners, even after adjusting for trauma and current socioeconomic adversity. Conclusions Prison experience is a marker of enduring psychiatric vulnerability, identifying an important target population for intervention and support. Moreover, the psychiatric attributes of ex-prisoners provide the context for recidivism. Without effective liaison between the criminal justice system and mental health services, the vulnerability of ex-prisoners to relapse and to reoffending will continue, with consequent personal and societal costs.


Author(s):  
Hira Rafi ◽  
Hamna Rafiq ◽  
Muhammad Farhan

Abstract Background Drug withdrawal syndrome occurs due to abrupt cessation of an addictive substance. Dependence to diazepam can be manifested by withdrawal syndrome which may include symptoms such as irritability, psychosis, sleep disturbance, seizures, mood disturbance, and anxiety. Studies have described the therapeutic role of agmatine in various neurological disorders such as depressive mood, learning deficits, anxiety, memory impairment, and psychosis. Various studies have also validated agmatine as a putant neuromodulator and revealed its mechanism of action with other neurotransmitters. The study was designed to reveal the potentials of agmatine in benzodiazepine withdrawal syndrome by maintaining GABA/glutamate balance. The study aimed to determine the underlying mechanism of action of agmatine at synaptic level using behavioral and biochemical evaluations. Results Agmatine significantly enhanced locomotion in open filed test and decreased anxiety as observed in elevated plus maze test (p < 0.01). Agmatine also reduced withdrawal symptoms scores along with compulsive behaviors in marble burying test and improved muscular strength by decreasing latency to fall in inverted screen test (p < 0.01). Moreover, agmatine established GABA/glutamate balance by increasing GABA levels and decreased glutamate concentration significantly (p < 0.01). Conclusion The present study reveals the possible mechanism of action of agmatine on NMDA receptor at GABA interneurons and glutamate post synaptic neuron that may lead to GABA/glutamate balance during withdrawal syndrome.


2004 ◽  
Vol 23 (4) ◽  
pp. 31-40 ◽  
Author(s):  
Susan Merle Gordon ◽  
Frank Tulak ◽  
Joseph Troncale

2011 ◽  
Vol 2 ◽  
Author(s):  
Daniele Stavros Hatzigiakoumis ◽  
Giovanni Martinotti ◽  
Massimo Di Giannantonio ◽  
Luigi Janiri

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